Rapid chiral separation of atenolol, metoprolol, propranolol and the zwitterionic metoprolol acid using supercritical fluid chromatography-tandem mass spectrometry - Application to wetland microcosms

Journal of Chromatography A

Volumn 1409, Issue , 2015, Pages 251-258

  Svan, Alfred ^a   Hedeland, Mikael ^a,b   Arvidsson, Torbjörn ^a,c   Jasper, Justin T ^d   Sedlak, David L ^d   Pettersson, Curt E ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b NATIONAL VETERINARY INSTITUTE   (Sweden)

^c MEDICAL PRODUCTS AGENCY   (Sweden)

^d Univ of California   (United States)

Author keywords

Chiralpak IB 3; Enantiomeric separation; Metoprolol acid; SFC MS; UPC2; Wetland microcosm

Indexed keywords

ADDITIVES; AMMONIA; CARBON DIOXIDE; CHIRALITY; EFFLUENT TREATMENT; ELECTROSPRAY IONIZATION; ENANTIOMERS; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; METHANOL; MOLAR RATIO; SUPERCRITICAL FLUIDS;

CHIRALPAK IB; ENANTIOMERIC SEPARATION; METOPROLOL; SFC-MS; UPC2;

WETLANDS;

ACETIC ACID; AMMONIA; ATENOLOL; CARBON DIOXIDE; DRUG METABOLITE; FORMIC ACID; METOPROLOL; PROPRANOLOL; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; ZWITTERIONIC METOPROLOL ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; WATER POLLUTANT;

ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; ELECTROSPRAY; ENANTIOMER; ENANTIOSELECTIVITY; FLOW RATE; LIMIT OF DETECTION; MEASUREMENT ACCURACY; MICROCOSM; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SUPERCRITICAL FLUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; WETLAND; ANALYSIS; ELECTROSPRAY MASS SPECTROMETRY; PROCEDURES; STEREOISOMERISM; WATER POLLUTANT;

ADRENERGIC BETA-ANTAGONISTS; ATENOLOL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; METOPROLOL; PROPRANOLOL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; WATER POLLUTANTS, CHEMICAL; WETLANDS;

EID: 84938738750     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2015.07.075     Document Type: Article

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