Deferoxamine Preconditioning of Neural-Like Cells Derived from Human Wharton’s Jelly Mesenchymal Stem Cells as a Strategy to Promote Their Tolerance and Therapeutic Potential: An In Vitro Study

Cellular and Molecular Neurobiology

Volumn 36, Issue 5, 2016, Pages 689-700

  Nouri, Fatemeh ^a   Salehinejad, Parvin ^b   Nematollahi mahani, Seyed Noureddin ^b   Kamarul, Tunku ^c   Zarrindast, Mohammad Reza ^d   Sharifi, Ali Mohammad ^a,c,e  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF MALAYA   (Malaysia)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

BDNF; Deferoxamine; Neural like cells; Preconditioning; VEGF

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DEFEROXAMINE; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL DEATH; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MESENCHYMAL STEM CELL; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; WHARTON JELLY; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; MESENCHYMAL STROMA CELL; METABOLISM;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DEFEROXAMINE; HUMANS; HYDROGEN PEROXIDE; MESENCHYMAL STROMAL CELLS; NEURONS; UP-REGULATION; WHARTON JELLY;

EID: 84938718961     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-015-0249-8     Document Type: Article

References (52)

1. Abdel-Salam OM (2011) Stem cell therapy for Alzheimer’s disease. CNS Neurol Disord 10(4):459–485
2. Almeida RD, Manadas BJ, Melo CV, Gomes JR, Mendes CS, Grãos MM, Carvalho RF, Carvalho AP, Duarte CB (2005) Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ 12(10):1329–1343
3. Amer J, Dana M, Fibach E (2010) The antioxidant effect of erythropoietin on thalassemic blood cells. Anemia. doi:10.1155/2010/978710
4. Bliss T, Guzman R, Daadi M, Steinberg G (2007) Stem cells and stroke recovery: introduction cell transplantation therapy for stroke. Stroke 38:817–826
5. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254
6. Brar VS, Sharma R, Murthy RK, Chalam KV (2010) Bevacizumab neutralizes the protective effect of vascular endothelial growth factor on retinal ganglion cells. Mol Vis 16:1848–1853
7. Byts N, Sirén AL (2009) Erythropoietin: a multimodal neuroprotective agent. Exp Transl Stroke Med 1:4
8. Chen W, Jadhav V, Tang J, Zhang JH (2008a) HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury. Acta Neurochir Suppl 102:395–399
9. Chen W, Jadhav V, Tang J, Zhang JH (2008b) HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiol Dis 31(3):433–441
10. Chen A, Xiong LJ, Tong Y, Mao M (2013a) The neuroprotective roles of BDNF in hypoxic ischemic brain injury (Review). Biomed Rep 1(2):167–176
11. Chen A, Xiong LJ, Tong Y, Mao M (2013b) Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3 K/Akt/mTOR pathway. Mol Med Rep 8(4):1011–1016
12. Eslami H, Sharifi AM, Rahimi H, Rahati M (2014) Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell. Neurosci Lett. doi:10.1016/j.neulet.2013.10.057
13. Gerber HP, Dixit V, Ferrara N (1998a) Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 273(21):13313–13316
14. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N (1998b) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway requirement for Flk-1/KDR activation. J Biol Chem 273(46):30336–30343
15. Gorres KL, Raines RT (2010) Prolyl 4-hydroxylase. Crit Rev Biochem Mol Biol 45(2):106–124
16. Helan M, Aravamudan B, Hartman WR, Thompson MA, Johnson BD, Pabelick CM, Prakash YS (2014) BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia. J Mol Cell Cardiol 68:89–97
17. Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson RS, Lipton SA, Barlow C (2005) Brain-specific knock-out of hypoxia-inducible factor-1 reduces rather than increases hypoxic-ischemic damage. J Neurosci 25(16):4099–4107
18. Hirota K, Semenza GL (2006) Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 59(1):15–26
19. Kannan K, Jain SK (2000) Oxidative stress and apoptosis. Pathophysiology 7(3):153–163
20. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680–685
21. Lalier L, Cartron PF, Juin P, Nedelkina S, Manon S, Bechinger B, Vallette FM (2007) Bax activation and mitochondrial insertion during apoptosis. Apoptosis 12(5):887–896
22. Langlois A, Bietiger W, Mandes K, Maillard E, Belcourt A, Pinget M, Kessler L, Sigrist S (2008) Overexpression of vascular endothelial growth factor in vitro using deferoxamine: a new drug to increase islet vascularization during transplantation. Transpl Proc 40(2):473–476
23. Li H, Gu B, Zhang Y, Lewis DF, Wang Y (2005) Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta. Placenta 26(2–3):210–217
24. Li Q, Michaud M, Stewart W, Schwartz M, Madri JA (2008) Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn. J Neurosci Res 86(6):1227–1242
25. Madri JA (2009) Modeling the neurovascular niche: implications for recovery from CNS injury. J Physiol Pharmacol 60(4):95–104
26. Majumdar D, Bhonde R, Datta I (2013) Influence of ischemic microenvironment on human Wharton’s Jelly mesenchymal stromal cells. Placenta 34(8):642–649
27. Martens L, Kirschner K, Warnecke C, Scholz H (2006) Hypoxia stimulates expression of the trkbneurotrophin receptor in vitro and in vivo. Acta Physiologica 186 Suppl 650:OM02–12
28. Martens LK, Kirschner KM, Warnecke C, Scholz H (2007) Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of the TrkBneurotrophin receptor gene. J Biol Chem 282(19):14379–14388
29. Mazumdar J, O’Brien WT, Johnson RS, La Manna JC, Chavez JC, Klein PS, Simon MC (2010) Neuronal Hif-1α regulates neurogenesis through Wnt/β-catenin signaling. Nat Cell Biol 12(10):1007–1013
30. Modo M, Stroemer RP, Tang E, Patel S, Hodges H (2003) Effects of implantation site of dead stem cells in rats with stroke damage. Neuroreport 14(1):39–42
31. Najafi R, Sharifi AM (2013) Deferoxamine preconditioning potentiates mesenchymal stem cell homing in vitro and in streptozotocin-diabetic rats. Expert Opin Biol Ther 13(7):959–972
32. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74(4):609–619
33. Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C (2002) Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol 283(5):L1133–L1142
34. Piret JP, Mottet D, Raes M, Michiels C (2002) Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochem Pharmacol 64(5–6):889–892
35. Potier E, Ferreira E, Dennler S, Mauviel A, Oudina K, Logeart-Avramoglou D, Petite H (2008) Desferrioxamine-driven upregulation of angiogenic factor expression by human bone marrow stromal cells. J Tissue Eng Regen Med 2(5):272–278
36. Salehinejad P, Alitheen NB, Ali AM, Omar AR, Mohit M, Janzamin E, Samani FS, Torshizi Z, Nematollahi-Mahani SN (2012) Comparison of different methods for the isolation of mesenchymal stem cells from human umbilical cord Wharton’s jelly, in vitro. Cell Dev Biol Animal 48:75–83
37. Salehinejad P, Alitheen N, Ali AM, Omar AR, Moshrefi M, Motamedi B, Nematollahi-mahani SN (2014) Neural differentiation of human umbilical cord matrix-derived mesenchymal cells under special culture conditions. Cytotechnology. doi:10.1007/s10616-014-9703-6
38. Scorrano L, Korsmeyer SJ (2013) Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 304(3):437–444
39. Sharifi AM, Mousavi SH, Jorjani M (2010) Effect of chronic lead exposure on pro-apoptotic Bax and anti-apoptotic Bcl-2 PROTEIN expression in rat hippocampus invivo. Cell Mol Neurobiol 30(5):769–774
40. Sortwell CE, Pitzer MR, Collier TJ (2000) Time course of apoptotic cell death within mesencephalic cell suspension grafts: implications for improving grafted dopamine neuron survival. Exp Neurol 165(2):268–277
41. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, Greenberg DA (2003) VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 111(12):1843–1851
42. Tavakol S, Aligholi H, Gorji A, Eshaghabadi A, Hoveizi E, Tavakol B, Rezayat SM, Ai J (2014) Thermogelnanofiber induces human endometrial-derived stromal cells to neural differentiation: in vitro and in vivo studies in rat. J Biomed Mater Res A 102(12):4590–4597
43. Tavakol S, ModarresMousavi SM, Massumi M, Amani A, Rezayat SM, Ai J (2015) The effect of Noggin supplementation in Matrigel nanofiber-based cell culture system for derivation of neural-like cells from human endometrial-derived stromal cells. J Biomed Mater Res A 103(1):1–7
44. Tejado A-M, Naranjo-Suarez S, Jiménez C, Carrera AC, Landázuri MO, del Peso L (2001) Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 276(25):22368–22374
45. Texel SJ, Zhang J, Camandola S, Unger EL, Taub DD, Koehler RC, Harris ZL, Mattson MP (2011) Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke. PLoS One 6(9):e25077
46. Tsai CY, Chan JY, Hsu KS, Chang AY, Chan SH (2012) Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS One 7(3):e33527
47. Wang GL, Semenza GL (1993) Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82(12):3610–3615
48. Wick A, Wick W, Waltenberger J, Weller M, Dichgans J, Schulz JB (2002) Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J Neurosci 22(15):6401–6407
49. Xiao H, Gu Z, Wang G, Zhao T (2013) The possible mechanisms underlying the impairment of HIF-1α pathway signaling in hyperglycemia and the beneficial effects of certain therapies. Int J Med Sci 10(10):1412–1421
50. Yamakawa M, Liu LX, Date T, Belanger AJ, Vincent KA, Akita GY, Kuriyama T, Cheng SH, Gregory RJ, Jiang C (2003) Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res 93(7):664–673
51. Zaman K, Ryu H, Hall D, O’Donovan K, Lin KI, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR (1999) Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. J Neurosci 19(22):9821–9830
52. Zawada WM, Zastrow DJ, Clarkson ED, Adams FS, Bell KP, Freed CR (1998) Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res 786(1–2):96–103