Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary 13C-glucose labeling metabolomics

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  D'Alessandro, Angelo ^a   Slaughter, Annie L ^a   Peltz, Erik D ^a   Moore, Ernest E ^a,b   Silliman, Christopher C ^a,c   Wither, Matthew ^a   Nemkov, Travis ^a   Bacon, Anthony W ^a   Fragoso, Miguel ^a,b   Banerjee, Anirban ^a   Hansen, Kirk C ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b DENVER HEALTH MEDICAL CENTER   (United States)

^c Bonfils Blood Center   (United States)

Author keywords

Acidosis; Gluconeogenesis; Glutaminolysis; Lactate; Mass spectrometry; Succinate

Indexed keywords

CARBON 13; CARBOXYLIC ACID; GLUCOSE; LACTIC ACID; MANNITOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); URATE; CARBON;

ABERRANT METABOLIC FLUX; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; ELECTRON TRANSPORT; GLYCOLYSIS; HEMORRHAGIC SHOCK; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INJURY; MASS SPECTROMETRY; METABOLIC DISORDER; METABOLOMICS; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; ANIMAL; BLOOD; ISOTOPE LABELING; METABOLIC FLUX ANALYSIS; METABOLISM; PROCEDURES;

ANIMALS; CARBON; GLYCOLYSIS; ISOTOPE LABELING; LACTIC ACID; METABOLIC FLUX ANALYSIS; METABOLOMICS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; WOUNDS AND INJURIES;

EID: 84938698536     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0612-z     Document Type: Article

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