Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry

Amino Acids

Volumn 47, Issue 11, 2015, Pages 2345-2357

  Nemkov, Travis ^a   D'Alessandro, Angelo ^a,b   Hansen, Kirk C ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Amino acids; Biofluid; Cell extract; Mass spectrometry; PLS DA; QExactive; Tissue extract

Indexed keywords

ARGININE; DRUG METABOLITE; FLUOROURACIL; GLUTAMIC ACID; GLUTAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LYSINE; AMINO ACID; HIF1A PROTEIN, RAT;

ACCURACY; AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD SAMPLING; CONTROLLED STUDY; HIGH RESOLUTION QUADRUPOLE ORBITRAP MASS SPECTROMETRY; INTERMETHOD COMPARISON; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIPID DIET; LOW FAT DIET; LUNG LAVAGE; MOUSE; MUSCLE TISSUE; NONHUMAN; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUADRUPOLE MASS SPECTROMETRY; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS; ANIMAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LYMPH; MASS SPECTROMETRY; METABOLISM; SPRAGUE DAWLEY RAT; TASTE BUD;

AMINO ACIDS; ANIMALS; BRONCHOALVEOLAR LAVAGE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEMORRHAGE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPH; MASS SPECTROMETRY; MICE; RATS; RATS, SPRAGUE-DAWLEY; TASTE BUDS;

EID: 84945482813     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-015-2019-9     Document Type: Article

References (56)

1. Amelio I, Cutruzzolá F, Antonov A et al (2014a) Serine and glycine metabolism in cancer. Trends Biochem Sci 39:191-198
2. Amelio I, Markert EK, Rufini A et al (2014b) p73 regulates serine biosynthesis in cancer. Oncogene 33(42):5039-5046
3. Armstrong M, Jonscher K, Reisdorph NA (2007) Analysis of 25 underivatized amino acids in human plasma using ion-pairing reversed-phase liquid chromatography/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom RCM 21:2717-2726
4. Badawy AA-B (2012) The EZ: faast family of amino acid analysis kits: application of the GC-FID kit for rapid determination of plasma tryptophan and other amino acids. Methods Mol Biol Clifton NJ 828:153-164
5. Benson JR, Hare PE (1975) O-phthalaldehyde: fluorogenic detection of primary amines in the picomole range. Comparison with fluorescamine and ninhydrin. Proc Natl Acad Sci U S A 72:619-622
6. Bidlingmeyer BA, Cohen SA, Tarvin TL (1984) Rapid analysis of amino acids using pre-column derivatization. J Chromatogr B Biomed Sci App 336:93-104
7. Buiarelli F, Gallo V, Di Filippo P et al (2013) Development of a method for the analysis of underivatized amino acids by liquid chromatography/tandem mass spectrometry: application on Standard Reference Material 1649a (urban dust). Talanta 115:966-972
8. Cardaci S, Ciriolo MR (2012) Deprive to kill: glutamine closes the gate to anticancer monocarboxylic drugs. Autophagy 8:1830-1832
9. Castorena CM, Arias EB, Sharma N, Cartee GD (2014) Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats. Diabetes 63:2297-2308
10. Chen G, Wang J (2014) Threonine metabolism and embryonic stem cell self-renewal. Curr Opin Clin Nutr Metab Care 17:80-85
11. Clasquin MF, Melamud E, Rabinowitz JD (2012) LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Curr Protoc Bioinforma Ed Board Andreas Baxevanis Al Chapter 14:Unit14.11
12. Cubbon S, Antonio C, Wilson J, Thomas-Oates J (2010) Metabolomic applications of HILIC-LC-MS. Mass Spectrom Rev 29:671-684
13. D'Alessandro A, Zolla L (2013) Proteomics and metabolomics in cancer drug development. Expert Rev Proteomics 10:473-488
14. D'Alessandro A, Gevi F, Zolla L (2011) A robust high resolution reversed-phase HPLC strategy to investigate various metabolic species in different biological models. Mol BioSyst 7:1024-1032
15. D'Alessandro A, Gevi F, Palini S et al (2012a) A mass spectrometry-based targeted metabolomics strategy of human blastocoele fluid: a promising tool in fertility research. Mol BioSyst 8:953-958
16. D'Alessandro A, Giardina B, Gevi F et al (2012b) Clinical metabolomics: the next stage of clinical biochemistry. Blood Transfus Trasfus Sangue 10(Suppl 2):s19-s24
17. D'Alessandro A, Amelio I, Berkers CR et al (2014a) Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. 5(17):7722-7733
18. D'Alessandro A, Cervia D, Catalani E et al (2014b) Protective effects of the neuropeptides PACAP, substance P and the somatostatin analogue octreotide in retinal ischemia: a metabolomic analysis. Mol BioSyst 10(6):1290-1304
19. D'Alessandro A, Nemkov T, Kelher M et al (2014c) Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. doi: 10.1111/trf.12975
20. D'Alessandro A, Kriebardis AG, Rinalducci S et al (2015a) An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion 55(1):205-219
21. D'Alessandro A, Moore HB, Moore EE et al (2015b) Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Regul Integr Comp Physiol. doi: 10.1152/ajpregu.00030.2015
22. Dorresteijn RC, Berwald LG, Zomer G et al (1996) Determination of amino acids using o-phthalaldehyde-2-mercaptoethanol derivatization effect of reaction conditions. J Chromatogr A 724:159-167
23. Droge W (2005) Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc B Biol Sci 360:2355-2372
24. Dunn WB, Lin W, Broadhurst D et al (2014) Molecular phenotyping of a UK population: defining the human serum metabolome. Metabolomics 11:9-26
25. Fonville JM, Richards SE, Barton RH et al (2010) The evolution of partial least squares models and related chemometric approaches in metabolomics and metabolic phenotyping. J Chemom 24:636-649
26. Fürst P, Pollack L, Graser TA et al (1990) Appraisal of four pre-column derivatization methods for the high-performance liquid chromatographic determination of free amino acids in biological materials. J Chromatogr 499:557-569
27. Heinrikson RL, Meredith SC (1984) Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate. Anal Biochem 136:65-74
28. Hirayama A, Soga T (2012) Amino acid analysis by capillary electrophoresis-mass spectrometry. Methods Mol Biol Clifton NJ 828:77-82
29. Hiscock N, Pedersen BK (2002) Exercise-induced immunodepression- plasma glutamine is not the link. J Appl Physiol 93:813-822
30. Husain FA, Martin MJ, Mullenix PS et al (2003) Serum lactate and base deficit as predictors of mortality and morbidity. Am J Surg 185:485-491
31. Kaspar H, Dettmer K, Gronwald W, Oefner PJ (2008) Automated GC-MS analysis of free amino acids in biological fluids. J Chromatogr B 870:222-232
32. Le A, Ng A, Kwan T et al (2014) A rapid, sensitive method for quantitative analysis of underivatized amino acids by liquid chromatography-tandem mass spectrometry (LC-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci 944:166-174
33. Maddocks ODK, Berkers CR, Mason SM et al (2013) Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493(542-546):3
34. Manning JM (1993) The contributions of Stein and Moore to protein science. Protein Sci Publ Protein Soc 2:1188-1191
35. Moore S, Spackman DH, Stein WH (1958) Chromatography of Amino Acids on Sulfonated Polystyrene Resins. An Improved System. Anal Chem 30:1185-1190
36. Morrison AB, Middleton EJ, McLaughlan JM (1961) Blood amino acid studies: ii. effects of dietary lysine concentration, sex, and growth rate on plasma free lysine and threonine levels in the rat. Can J Biochem Physiol 39:1675-1680
37. Pan Z, Gu H, Talaty N et al (2007) Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Anal Bioanal Chem 387:539-549
38. Panopoulos AD, Yanes O, Ruiz S et al (2012) The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res 22:168-177
39. Peltz E, D'Alessandro A, Moore E et al (2015) Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury. J Trauma Acute Care Surg. doi: 10.1097/TA.0000000000000589
40. Piraud M, Vianey-Saban C, Petritis K et al (2005) Ion-pairing reversed-phase liquid chromatography/electrospray ionization mass spectrometric analysis of 76 underivatized amino acids of biological interest: a new tool for the diagnosis of inherited disorders of amino acid metabolism. Rapid Commun Mass Spectrom 19:1587-1602
41. Platten M, Wick W, Van den Eynde BJ (2012) Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res 72:5435-5440
42. Prada PO, Hirabara SM, de Souza CT et al (2007) l-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity. Diabetologia 50:1949-1959
43. Rutherfurd SM, Gilani GS (2009) Amino acid analysis. Curr Protoc Protein Sci Editor Board John E Coligan Al Chapter 11:Unit 11.9
44. Salazar C, Armenta JM, Cortés DF, Shulaev V (2012) Combination of an AccQ·Tag-ultra performance liquid chromatographic method with tandem mass spectrometry for the analysis of amino acids. Methods Mol Biol Clifton NJ 828:13-28
45. Shimbo K, Oonuki T, Yahashi A et al (2009) Precolumn derivatization reagents for high-speed analysis of amines and amino acids in biological fluid using liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 23:1483-1492
46. Stein S, Böhlen P, Stone J et al (1973) Amino acid analysis with fluorescamine at the picomole level. Arch Biochem Biophys 155:203-212
47. Stringham JR, Moore EE, Gamboni F et al (2014) Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock. J Trauma Acute Care Surg 76:1214-1221
48. Thiele B, Stein N, Oldiges M, Hofmann D (2012) Direct analysis of underivatized amino acids in plant extracts by LC-MS-MS. Methods Mol Biol Clifton NJ 828:317-328
49. Vandenbeuch A, Tizzano M, Anderson CB et al (2010) Evidence for a role of glutamate as an efferent transmitter in taste buds. BMC Neurosci 11:77
50. Yamaguchi S, Ninomiya K (2000) Umami and Food Palatability. J Nutr 130:921S-926S
51. Yang X-D, Ma JYC, Barger MW, Ma JKH (2002) Transport and utilization of arginine and arginine-containing peptides by rat alveolar macrophages. Pharm Res 19:825-831
52. Yang W-C, Mirzaei H, Liu X, Regnier FE (2006) Enhancement of amino acid detection and quantification by electrospray ionization mass spectrometry. Anal Chem 78:4702-4708
53. Yao X, Zhou G, Tang Y et al (2013) Direct determination of underivatized amino acids from Ginkgo biloba leaves by using hydrophilic interaction ultra high performance liquid chromatography coupled with triple quadrupole mass spectrometry. J Sep Sci 36:2878-2887
54. Yuan M, Breitkopf SB, Yang X, Asara JM (2012) A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue. Nat Protoc 7:872-881
55. Zhang Y, Dai Y, Wen J et al (2011) Detrimental effects of adenosine signaling in sickle cell disease. Nat Med 17:79-86
56. Zhou G, Pang H, Tang Y et al (2013) Hydrophilic interaction ultra-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry for highly rapid and sensitive analysis of underivatized amino acids in functional foods. Amino Acids 44:1293-1305