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Volumn 47, Issue 6, 2015, Pages 551-556

KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: Observational analysis of 175 cases

Author keywords

BRAF; colorectal cancer; KRAS; NRAS; poorly differentiated clusters

Indexed keywords

B RAF KINASE; BRAF PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE; KRAS PROTEIN, HUMAN; MEMBRANE PROTEIN; NRAS PROTEIN, HUMAN; PROTEIN P21; TUMOR MARKER;

EID: 84938644063     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0000000000000300     Document Type: Article
Times cited : (37)

References (38)
  • 1
    • 84864426225 scopus 로고    scopus 로고
    • Progress in colorectal cancer survival in Europe from the late 1980s to the early 21st century: The EUROCARE study
    • Brenner H, Bouvier AM, Foschi R, et al. Progress in colorectal cancer survival in Europe from the late 1980s to the early 21st century: the EUROCARE study. Int J Cancer 2012; 131: 1649-58.
    • (2012) Int J Cancer , vol.131 , pp. 1649-1658
    • Brenner, H.1    Bouvier, A.M.2    Foschi, R.3
  • 2
    • 84857720543 scopus 로고    scopus 로고
    • New criteria for histologic grading of colorectal cancer
    • Ueno H, Kajiwara Y, Shimazaki H, et al. New criteria for histologic grading of colorectal cancer. Am J Surg Pathol 2012; 36: 193-201.
    • (2012) Am J Surg Pathol , vol.36 , pp. 193-201
    • Ueno, H.1    Kajiwara, Y.2    Shimazaki, H.3
  • 3
    • 84871501676 scopus 로고    scopus 로고
    • Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than conventional grading
    • Barresi V, Reggiani Bonetti L, Branca G, et al. Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than conventional grading. Virchows Arch 2012; 461: 621-8.
    • (2012) Virchows Arch , vol.461 , pp. 621-628
    • Barresi, V.1    Reggiani Bonetti, L.2    Branca, G.3
  • 4
    • 84892790948 scopus 로고    scopus 로고
    • Histologic grading based on counting poorly differentiated clusters in preoperative biopsy predicts nodal involvement and pTNM stage in colorectal cancer patients
    • Barresi V, Bonetti LR, Ieni A, et al. Histologic grading based on counting poorly differentiated clusters in preoperative biopsy predicts nodal involvement and pTNM stage in colorectal cancer patients. Hum Pathol 2014; 45: 268-75.
    • (2014) Hum Pathol , vol.45 , pp. 268-275
    • Barresi, V.1    Bonetti, L.R.2    Ieni, A.3
  • 5
    • 84902329015 scopus 로고    scopus 로고
    • Poorly differentiated clusters (PDCs) as a novel histological predictor of nodal metastases in pT1 colorectal cancer
    • Barresi V, Branca G, Ieni A. Poorly differentiated clusters (PDCs) as a novel histological predictor of nodal metastases in pT1 colorectal cancer. Virchows Arch 2014; 464: 655-62.
    • (2014) Virchows Arch , vol.464 , pp. 655-662
    • Barresi, V.1    Branca, G.2    Ieni, A.3
  • 6
    • 84893006967 scopus 로고    scopus 로고
    • Site-specific tumor grading system in colorectal cancer: Multicenter pathologic review of the value of quantifying poorly differentiated clusters
    • Ueno H, Hase K, Hashiguchi Y, et al. Site-specific tumor grading system in colorectal cancer: multicenter pathologic review of the value of quantifying poorly differentiated clusters. Am J Surg Pathol 2014; 38: 197-204.
    • (2014) Am J Surg Pathol , vol.38 , pp. 197-204
    • Ueno, H.1    Hase, K.2    Hashiguchi, Y.3
  • 7
    • 84908263241 scopus 로고    scopus 로고
    • Novel risk factors for lymph node metastasis in early invasive colorectal cancer: A multi-institution pathology review
    • Ueno H, Hase K, Hashiguchi Y, et al. Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review. J Gastroenterol 2014; 49: 1314-23.
    • (2014) J Gastroenterol , vol.49 , pp. 1314-1323
    • Ueno, H.1    Hase, K.2    Hashiguchi, Y.3
  • 8
    • 84907171211 scopus 로고    scopus 로고
    • Micropapillary pattern and poorly differentiated clusters represent the same biological phenomenon in colorectal cancer: A proposal for a change in terminology
    • Barresi V, Branca G, Vitarelli E, et al. Micropapillary pattern and poorly differentiated clusters represent the same biological phenomenon in colorectal cancer: a proposal for a change in terminology. Am J Clin Pathol 2014; 142: 375-83.
    • (2014) Am J Clin Pathol , vol.142 , pp. 375-383
    • Barresi, V.1    Branca, G.2    Vitarelli, E.3
  • 9
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas NetworkComprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-7.
    • (2012) Nature , vol.487 , pp. 330-337
    • Cancer Genome Atlas Network1
  • 10
    • 84865744415 scopus 로고    scopus 로고
    • Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wildtype colorectal cancers
    • Imamura Y, Morikawa T, Liao X, et al. Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wildtype colorectal cancers. Clin Cancer Res 2012; 18: 4753-63.
    • (2012) Clin Cancer Res , vol.18 , pp. 4753-4763
    • Imamura, Y.1    Morikawa, T.2    Liao, X.3
  • 11
    • 84902532849 scopus 로고    scopus 로고
    • Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: Cohort study and literature review
    • Imamura Y, Lochhead P, Yamauchi M, et al. Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review. Mol Cancer 2014; 13: 135.
    • (2014) Mol Cancer , vol.13 , pp. 135
    • Imamura, Y.1    Lochhead, P.2    Yamauchi, M.3
  • 12
    • 23944488225 scopus 로고    scopus 로고
    • The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma
    • Conlin A, Smith G, Carey FA, et al. The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma. Gut 2005; 54: 1283-6.
    • (2005) Gut , vol.54 , pp. 1283-1286
    • Conlin, A.1    Smith, G.2    Carey, F.A.3
  • 13
    • 77953725220 scopus 로고    scopus 로고
    • Targeted treatments in colorectal cancer: State of the art and future perspectives
    • Arnold D, Seufferlein T. Targeted treatments in colorectal cancer: state of the art and future perspectives. Gut 2010; 59: 838-58.
    • (2010) Gut , vol.59 , pp. 838-858
    • Arnold, D.1    Seufferlein, T.2
  • 14
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010; 11: 753-62.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 15
    • 84892425103 scopus 로고    scopus 로고
    • Effectors of epidermal growth factor receptor pathway: The genetic profiling ofKRAS, BRAF, PIK3CA, NRAS mutations in colorectal cancer characteristics and personalized medicine
    • Shen Y, Wang J, Han X, et al. Effectors of epidermal growth factor receptor pathway: the genetic profiling ofKRAS, BRAF, PIK3CA, NRAS mutations in colorectal cancer characteristics and personalized medicine. PLoSOne 2013; 8: e81628.
    • (2013) PLoSOne , vol.8
    • Shen, Y.1    Wang, J.2    Han, X.3
  • 16
    • 84856512550 scopus 로고    scopus 로고
    • Predictive and prognostic roles of BRAF mutation in stage III colon cancer: Results from intergroup trial CALGB 89803
    • Ogino S, Shima K, Meyerhardt JA, et al. Predictive and prognostic roles of BRAF mutation in stage III colon cancer: Results from intergroup trial CALGB 89803. Clin Cancer Res 2012; 18: 890-900.
    • (2012) Clin Cancer Res , vol.18 , pp. 890-900
    • Ogino, S.1    Shima, K.2    Meyerhardt, J.A.3
  • 17
    • 84870339415 scopus 로고    scopus 로고
    • Mutation profiling and microsatellite instability in stage II and III colon cancer: An assessment of their prognostic and oxaliplatin predictive value
    • Gavin PG, Colangelo LH, Fumagalli D, et al. Mutation profiling and microsatellite instability in stage II and III colon cancer: an assessment of their prognostic and oxaliplatin predictive value. Clin Cancer Res 2012; 18: 6531-41.
    • (2012) Clin Cancer Res , vol.18 , pp. 6531-6541
    • Gavin, P.G.1    Colangelo, L.H.2    Fumagalli, D.3
  • 20
    • 0842327244 scopus 로고    scopus 로고
    • Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancer
    • Ueno H, Mochizuki H, Hashiguchi Y, et al. Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancer. Ann Surg 2004; 239: 34-42.
    • (2004) Ann Surg , vol.239 , pp. 34-42
    • Ueno, H.1    Mochizuki, H.2    Hashiguchi, Y.3
  • 21
    • 84929045018 scopus 로고    scopus 로고
    • Prognostic value of poorly differentiated clusters in the primary tumor in patients undergoing hepatectomy for colorectal liver metastasis
    • Ueno H, Konishi T, Ishikawa Y, et al. Prognostic value of poorly differentiated clusters in the primary tumor in patients undergoing hepatectomy for colorectal liver metastasis. Surgery 2015; 157: 899-908.
    • (2015) Surgery , vol.157 , pp. 899-908
    • Ueno, H.1    Konishi, T.2    Ishikawa, Y.3
  • 22
    • 84931011311 scopus 로고    scopus 로고
    • Correlation between microsatellite instability status and grading assessed by the counting of poorly differentiated clusters in colorectal cancer
    • Barresi V, Bonetti LR. Correlation between microsatellite instability status and grading assessed by the counting of poorly differentiated clusters in colorectal cancer. Hum Pathol 2015; 46: 1063.
    • (2015) Hum Pathol , vol.46 , pp. 1063
    • Barresi, V.1    Bonetti, L.R.2
  • 23
    • 84908207866 scopus 로고    scopus 로고
    • Should the grading of colorectal adenocarcinoma include microsatellite instability status?
    • Rosty C, Williamson EJ, Clendenning M, et al. Should the grading of colorectal adenocarcinoma include microsatellite instability status? Hum Pathol 2014; 45: 2077-84.
    • (2014) Hum Pathol , vol.45 , pp. 2077-2084
    • Rosty, C.1    Williamson, E.J.2    Clendenning, M.3
  • 24
    • 84905992413 scopus 로고    scopus 로고
    • Invasion pattern and histologic features of tumor aggressiveness correlate with MMR protein expression, but are independent of activating KRAS and BRAF mutations in CRC
    • Steinestel K, Lennerz JK, Eder S, et al. Invasion pattern and histologic features of tumor aggressiveness correlate with MMR protein expression, but are independent of activating KRAS and BRAF mutations in CRC. Virchows Arch 2014; 465: 155-63.
    • (2014) Virchows Arch , vol.465 , pp. 155-163
    • Steinestel, K.1    Lennerz, J.K.2    Eder, S.3
  • 25
    • 84878549248 scopus 로고    scopus 로고
    • Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
    • Rosty C, Young JP, Walsh MD, Clendenning M, Walters RJ, Pearson S. Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features. Mod Pathol 2013; 26: 825-34.
    • (2013) Mod Pathol , vol.26 , pp. 825-834
    • Rosty, C.1    Young, J.P.2    Walsh, M.D.3    Clendenning, M.4    Walters, R.J.5    Pearson, S.6
  • 26
    • 62449313740 scopus 로고    scopus 로고
    • Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B
    • Asaka S, Arai Y, Nishimura Y, et al. Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B. Carcinogenesis 2009; 30: 494-9.
    • (2009) Carcinogenesis , vol.30 , pp. 494-499
    • Asaka, S.1    Arai, Y.2    Nishimura, Y.3
  • 27
    • 80053172696 scopus 로고    scopus 로고
    • BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: A comparative study
    • Makrodouli E, Oikonomou E, Koc M, et al. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. Mol Cancer 2011; 10: 118.
    • (2011) Mol Cancer , vol.10 , pp. 118
    • Makrodouli, E.1    Oikonomou, E.2    Koc, M.3
  • 28
    • 84881256021 scopus 로고    scopus 로고
    • Companion-diagnostic testing limited to KRAS codons 12 and 13 misses 17% of potentially relevant RAS mutations in colorectal cancer
    • Netzel BC, Grebe SK. Companion-diagnostic testing limited to KRAS codons 12 and 13 misses 17% of potentially relevant RAS mutations in colorectal cancer. Clin Chim Acta 2013; 21: 1-2.
    • (2013) Clin Chim Acta , vol.21 , pp. 1-2
    • Netzel, B.C.1    Grebe, S.K.2
  • 29
    • 77953688634 scopus 로고    scopus 로고
    • Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis
    • Zlobec I, Bihl MP, Schwarb H, et al. Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. Int J Cancer 2010; 15: 367-80.
    • (2010) Int J Cancer , vol.15 , pp. 367-380
    • Zlobec, I.1    Bihl, M.P.2    Schwarb, H.3
  • 30
    • 84867628245 scopus 로고    scopus 로고
    • Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma
    • Benedix F, Meyer F, Kube R, et al. Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma. Pathol Res Pract 2012; 15: 592-7.
    • (2012) Pathol Res Pract , vol.15 , pp. 592-597
    • Benedix, F.1    Meyer, F.2    Kube, R.3
  • 31
    • 84905739060 scopus 로고    scopus 로고
    • The prognostic role of microsatellite instability, codon-specific KRAS,and BRAF mutations in colon cancer
    • Lin CC, Lin JK, Lin TC, et al. The prognostic role of microsatellite instability, codon-specific KRAS,and BRAF mutations in colon cancer. J Surg Oncol 2014; 110: 451-7.
    • (2014) J Surg Oncol , vol.110 , pp. 451-457
    • Lin, C.C.1    Lin, J.K.2    Lin, T.C.3
  • 32
    • 79955572697 scopus 로고    scopus 로고
    • Clinicopathological and molecular characterization of colorectal micropapillary carcinoma
    • Verdú M, Román R, Calvo M, et al. Clinicopathological and molecular characterization of colorectal micropapillary carcinoma. Mod Pathol 2011; 24: 729-38.
    • (2011) Mod Pathol , vol.24 , pp. 729-738
    • Verdú, M.1    Román, R.2    Calvo, M.3
  • 33
    • 42649125571 scopus 로고    scopus 로고
    • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
    • Haigis KM, Kendall KR, Wang Y, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 2008; 40: 600-8.
    • (2008) Nat Genet , vol.40 , pp. 600-608
    • Haigis, K.M.1    Kendall, K.R.2    Wang, Y.3
  • 34
    • 84904024982 scopus 로고    scopus 로고
    • KRAS and YAP1 converge to regulate EMT and tumor survival
    • Shao DD, Xue W, Krall EB, et al. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell 2014; 3: 171-84.
    • (2014) Cell , vol.3 , pp. 171-184
    • Shao, D.D.1    Xue, W.2    Krall, E.B.3
  • 35
    • 79952698464 scopus 로고    scopus 로고
    • Activated KrasG12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin
    • Rachagani S, Senapati S, Chakraborty S, et al. Activated KrasG12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. Br J Cancer 2011; 15: 1038-48.
    • (2011) Br J Cancer , vol.15 , pp. 1038-1048
    • Rachagani, S.1    Senapati, S.2    Chakraborty, S.3
  • 36
    • 84907286219 scopus 로고    scopus 로고
    • Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells
    • Satow R, Hirano T, Batori R, et al. Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells. Proc Natl Acad Sci USA 2014; 111: 13505-10.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 13505-13510
    • Satow, R.1    Hirano, T.2    Batori, R.3
  • 37
    • 35348914681 scopus 로고    scopus 로고
    • High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations
    • Prall F, Ostwald C. High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations. Hum Pathol 2007; 38: 1696-702.
    • (2007) Hum Pathol , vol.38 , pp. 1696-1702
    • Prall, F.1    Ostwald, C.2
  • 38
    • 0035444798 scopus 로고    scopus 로고
    • Ras mutations in patients with colorectal cancer: The "RASCAL II" study
    • Andreyev HJN, Norman AR, Cuningham D, et al. Ras mutations in patients with colorectal cancer: the "RASCAL II" study. Br J Cancer 2001; 85: 692-6.
    • (2001) Br J Cancer , vol.85 , pp. 692-696
    • Andreyev, H.J.N.1    Norman, A.R.2    Cuningham, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.