-
1
-
-
84878928981
-
Targeted therapy in metastatic colorectal cancer - an example of personalised medicine in action
-
Heinemann V, Douillard JY, Ducreux M, PeetersM (2013) Targeted therapy in metastatic colorectal cancer - an example of personalised medicine in action. Cancer Treat Rev 39(6):592-601.
-
(2013)
Cancer Treat Rev
, vol.39
, Issue.6
, pp. 592-601
-
-
Heinemann, V.1
Douillard, J.Y.2
Ducreux, M.3
Peeters, M.4
-
2
-
-
84872115684
-
Quality of life analysis in patients with KRAS wild-type metastatic colorectal cancer treated first-line with cetuximab plus irinotecan, fluorouracil and leucovorin
-
Láng I, et al. (2013) Quality of life analysis in patients with KRAS wild-type metastatic colorectal cancer treated first-line with cetuximab plus irinotecan, fluorouracil and leucovorin. Eur J Cancer 49(2):439-448.
-
(2013)
Eur J Cancer
, vol.49
, Issue.2
, pp. 439-448
-
-
Láng, I.1
-
3
-
-
70450195266
-
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
-
Normanno N, et al. (2009) Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nat Rev Clin Oncol 6(9):519-527.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, Issue.9
, pp. 519-527
-
-
Normanno, N.1
-
4
-
-
84906053914
-
RAS signaling pathways, mutations and their role in colorectal cancer
-
Zenonos K, Kyprianou K (2013) RAS signaling pathways, mutations and their role in colorectal cancer. World J Gastrointest Oncol 5(5):97-101.
-
(2013)
World J Gastrointest Oncol
, vol.5
, Issue.5
, pp. 97-101
-
-
Zenonos, K.1
Kyprianou, K.2
-
5
-
-
4143146567
-
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells
-
Agbunag C, Bar-Sagi D (2004) Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res 64(16):5659-5663.
-
(2004)
Cancer Res
, vol.64
, Issue.16
, pp. 5659-5663
-
-
Agbunag, C.1
Bar-Sagi, D.2
-
6
-
-
79952698464
-
Activated KrasGD is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin
-
Rachagani S, et al. (2011) Activated KrasGD is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. Br J Cancer 104(6):1038-1048.
-
(2011)
Br J Cancer
, vol.104
, Issue.6
, pp. 1038-1048
-
-
Rachagani, S.1
-
7
-
-
84885769048
-
The physiological roles of primary phospholipase C
-
Yang YR, Follo MY, Cocco L, Suh PG (2013) The physiological roles of primary phospholipase C. Adv Biol Regul 53(3):232-241.
-
(2013)
Adv Biol Regul
, vol.53
, Issue.3
, pp. 232-241
-
-
Yang, Y.R.1
Follo, M.Y.2
Cocco, L.3
Suh, P.G.4
-
8
-
-
80052353715
-
Phospholipase C isozymes are deregulated in colorectal cancer-insights gained from gene set enrichment analysis of the transcriptome
-
Danielsen SA, et al. (2011) Phospholipase C isozymes are deregulated in colorectal cancer-insights gained from gene set enrichment analysis of the transcriptome. PLoS ONE 6(9):e24419.
-
(2011)
PLoS ONE
, vol.6
, Issue.9
, pp. e24419
-
-
Danielsen, S.A.1
-
9
-
-
57649215701
-
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases
-
Seifert JP, Zhou Y, Hicks SN, Sondek J, Harden TK (2008) Dual activation of phospholipase C-epsilon by Rho and Ras GTPases. J Biol Chem 283(44):29690-29698.
-
(2008)
J Biol Chem
, vol.283
, Issue.44
, pp. 29690-29698
-
-
Seifert, J.P.1
Zhou, Y.2
Hicks, S.N.3
Sondek, J.4
Harden, T.K.5
-
10
-
-
69449092270
-
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis
-
Li M, Edamatsu H, Kitazawa R, Kitazawa S, Kataoka T (2009) Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis 30(8):1424-1432
-
(2009)
Carcinogenesis
, vol.30
, Issue.8
, pp. 1424-1432
-
-
Li, M.1
Edamatsu, H.2
Kitazawa, R.3
Kitazawa, S.4
Kataoka, T.5
-
11
-
-
84866284453
-
Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer
-
Wang X, et al. (2012) Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer. Med Oncol 29(2):1051-1058.
-
(2012)
Med Oncol
, vol.29
, Issue.2
, pp. 1051-1058
-
-
Wang, X.1
-
12
-
-
33847345143
-
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
-
Buck E, et al. (2007) Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition. Mol Cancer Ther 6(2):532-541.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.2
, pp. 532-541
-
-
Buck, E.1
-
13
-
-
44649099646
-
Regulation of Wnt signaling by the nuclear pore complex
-
Shitashige M, et al. (2008) Regulation of Wnt signaling by the nuclear pore complex. Gastroenterology 134(7):1961-1971.
-
(2008)
Gastroenterology
, vol.134
, Issue.7
, pp. 1961-1971
-
-
Shitashige, M.1
-
14
-
-
84857574310
-
β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells
-
Satow R, et al. (2012) β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. Gastroenterology 142(3):572-581.
-
(2012)
Gastroenterology
, vol.142
, Issue.3
, pp. 572-581
-
-
Satow, R.1
-
15
-
-
0345599013
-
Autoregulation of E-cadherin expression by cadherincadherin interactions: The roles of beta-catenin signaling, Slug, and MAPK
-
Conacci-Sorrell M, et al. (2003) Autoregulation of E-cadherin expression by cadherincadherin interactions: The roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol 163(4):847-857.
-
(2003)
J Cell Biol
, vol.163
, Issue.4
, pp. 847-857
-
-
Conacci-Sorrell, M.1
-
16
-
-
33847324442
-
Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: A tissue microarray-based analysis
-
Lugli A, et al. (2007) Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: A tissue microarray-based analysis. Histopathology 50(4):453-464.
-
(2007)
Histopathology
, vol.50
, Issue.4
, pp. 453-464
-
-
Lugli, A.1
-
17
-
-
79961087833
-
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
-
Kim NG, Koh E, Chen X, Gumbiner BM (2011) E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci USA 108(29):11930-11935.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.29
, pp. 11930-11935
-
-
Kim, N.G.1
Koh, E.2
Chen, X.3
Gumbiner, B.M.4
-
18
-
-
79958789619
-
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression
-
Lau MT, Klausen C, Leung PC (2011) E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. Oncogene 30(24):2753-2766.
-
(2011)
Oncogene
, vol.30
, Issue.24
, pp. 2753-2766
-
-
Lau, M.T.1
Klausen, C.2
Leung, P.C.3
-
19
-
-
0006224409
-
Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro
-
Shin SI, Freedman VH, Risser R, Pollack R (1975) Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci USA 72(11):4435-4439.
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, Issue.11
, pp. 4435-4439
-
-
Shin, S.I.1
Freedman, V.H.2
Risser, R.3
Pollack, R.4
-
20
-
-
1042291164
-
Down-regulation of MEK/ ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells
-
Laprise P, Langlois MJ, Boucher MJ, Jobin C, Rivard N (2004) Down-regulation of MEK/ ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells. J Cell Physiol 199(1):32-39.
-
(2004)
J Cell Physiol
, vol.199
, Issue.1
, pp. 32-39
-
-
Laprise, P.1
Langlois, M.J.2
Boucher, M.J.3
Jobin, C.4
Rivard, N.5
-
21
-
-
84864282082
-
Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis
-
Chen X, et al. (2012) Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis. Mol Biol Rep 39(6):6707-6714.
-
(2012)
Mol Biol Rep
, vol.39
, Issue.6
, pp. 6707-6714
-
-
Chen, X.1
-
22
-
-
0030726150
-
Prognostic significance of E-cadherin expression in human colorectal cancer tissue
-
Mohri Y (1997) Prognostic significance of E-cadherin expression in human colorectal cancer tissue. Surg Today 27(7):606-612.
-
(1997)
Surg Today
, vol.27
, Issue.7
, pp. 606-612
-
-
Mohri, Y.1
-
23
-
-
77951155224
-
Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells
-
Roger L, Jullien L, Gire V, Roux P (2010) Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells. J Cell Sci 123(Pt 8):1295-1305.
-
(2010)
J Cell Sci
, vol.123
, pp. 1295-1305
-
-
Roger, L.1
Jullien, L.2
Gire, V.3
Roux, P.4
-
24
-
-
80053172696
-
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: A comparative study
-
Makrodouli E, et al. (2011) BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: A comparative study. Mol Cancer 10:118.
-
(2011)
Mol Cancer
, vol.10
, pp. 118
-
-
Makrodouli, E.1
-
25
-
-
44449111555
-
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
-
Onder TT, et al. (2008) Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68(10):3645-3654.
-
(2008)
Cancer Res
, vol.68
, Issue.10
, pp. 3645-3654
-
-
Onder, T.T.1
-
26
-
-
0037938632
-
Phospholipase Cdelta1 is required for skin stem cell lineage commitment
-
Nakamura Y, et al. (2003) Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J 22(12):2981-2991.
-
(2003)
EMBO J
, vol.22
, Issue.12
, pp. 2981-2991
-
-
Nakamura, Y.1
-
27
-
-
0037224244
-
Extracellular calcium and calcium sensing receptor function in human colon carcinomas: Promotion of E-cadherin expression and suppression of beta-catenin/TCF activation
-
Chakrabarty S, Radjendirane V, Appelman H, Varani J (2003) Extracellular calcium and calcium sensing receptor function in human colon carcinomas: Promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res 63(1):67-71.
-
(2003)
Cancer Res
, vol.63
, Issue.1
, pp. 67-71
-
-
Chakrabarty, S.1
Radjendirane, V.2
Appelman, H.3
Varani, J.4
-
28
-
-
0033105411
-
Genetic pathways in colorectal and other cancers
-
Ilyas M, Straub J, Tomlinson IP, Bodmer WF (1999) Genetic pathways in colorectal and other cancers. Eur J Cancer 35(14):1986-2002.
-
(1999)
Eur J Cancer
, vol.35
, Issue.14
, pp. 1986-2002
-
-
Ilyas, M.1
Straub, J.2
Tomlinson, I.P.3
Bodmer, W.F.4
-
29
-
-
84864863410
-
Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice
-
Kanemaru K, et al. (2012) Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun 3:963.
-
(2012)
Nat Commun
, vol.3
, pp. 963
-
-
Kanemaru, K.1
-
30
-
-
79956196860
-
Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells
-
Kouchi Z, Fujiwara Y, Yamaguchi H, Nakamura Y, Fukami K (2011) Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem Biophys Res Commun 408(4):523-529.
-
(2011)
Biochem Biophys Res Commun
, vol.408
, Issue.4
, pp. 523-529
-
-
Kouchi, Z.1
Fujiwara, Y.2
Yamaguchi, H.3
Nakamura, Y.4
Fukami, K.5
-
31
-
-
84887064292
-
Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness
-
Hirano T, et al. (2013) Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochem Pharmacol 86(10):1419-1429.
-
(2013)
Biochem Pharmacol
, vol.86
, Issue.10
, pp. 1419-1429
-
-
Hirano, T.1
|