Molecular mechanisms mediating the adaptive regulation of intestinal riboflavin uptake process

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Subramanian, Veedamali S ^a,c   Ghosal, Abhisek ^a,c   Kapadia, Rubina ^a,c   Nabokina, Svetlana M ^a,c   Said, Hamid M ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RIBOFLAVIN; TRANSCRIPTION FACTOR SP1; CARRIER PROTEIN; HISTONE; LYSINE;

ARTICLE; CELL SURFACE; EPIGENETICS; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; HISTONE MODIFICATION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SLC52A3 GENE; ADAPTATION; CELL LINE; CELL MEMBRANE; DIETARY SUPPLEMENT; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; INTESTINE; METABOLISM; METHYLATION; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION;

ADAPTATION, PHYSIOLOGICAL; CELL LINE; CELL MEMBRANE; DIETARY SUPPLEMENTS; ENTEROCYTES; GENE EXPRESSION REGULATION; HISTONES; HUMANS; INTESTINES; LYSINE; MEMBRANE TRANSPORT PROTEINS; METHYLATION; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RIBOFLAVIN; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 84938634550     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0131698     Document Type: Article

References (46)

1. Cooperman JM, Lopez R (1984). Riboflavin. In: Handbook of vitamins: Nutritional, Biochemical and Clinical Aspects, edited by Machlin LJ. New York: Dekker. 299-327.
2. Tu BP, Ho-Schleyer SC, Travers KJ, Weissman JS (2000). Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science 290: 1571-74. PMID: 11090354
3. Iwanaga K, Hasegawa T, Hultquist DE, Harada H, Yoshikawa Y, Yanamadala S, et al (2007). Riboflavin-mediated reduction of oxidant injury, rejection, and vasculopathy after cardiac allotransplantation. Transplant 83:747-53.
4. Sanches SC, Ramalho LN, Mendes-Bras M, Terra VA, Cecchini R, Augusto MJ, et al (2014). Riboflavin (vitamin B-2) reduces hepatocellular injury following liver ischaemia and reperfusion in mice. Food Chem Toxicol 67: 65-7. doi: 10.1016/j.fct.2014.02.013 PMID: 24560968
5. Seekamp A, Hultquist DE, Till GO (1999). Protection by vitamin B2 against oxidant-mediated acute lung injury. Inflamm 23: 449-60.
6. Liu D, Zempleni J (2014). Low activity of LSD1 elicits a pro-inflammatory gene expression profile in riboflavin-deficient human T Lymphoma Jurkat cells. Genes Nutr 9: 422. doi: 10.1007/s12263-014-0422-6 PMID: 25103574
7. Mazur-Bialy AI, Buchala B, Plytycz B (2013). Riboflavin deprivation inhibits macrophage viability and activity - a study on the RAW 264.7 cell line. Br J Nutr 110: 509-14. doi: 10.1017/S0007114512005351 PMID: 23415257
8. Schramm M, Wiegmann K, Schramm S, Gluschko A, Herb M, Utermohlen O, et al (2014). Riboflavin (vitamin B2) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes. Eur J Immunol 44: 728-41. doi: 10.1002/eji.201343940 PMID: 24272050
9. Nakano E, Mushtaq S, Heath PR, Lee S, Bury JP, Riley SA, et al (2011). Riboflavin Depletion Impairs Cell Proliferation in Adult Human Duodenum: Identification of Potential Effectors. Dig Dis Sci 56:1007-19. doi: 10.1007/s10620-010-1374-3 PMID: 20848206
10. Rivilin RS (2010). Riboflavin. Encyclopedia of Dietary supplements. Coates P.M., Betz J. M., Blackman M. R. et al. London and New York, Informa healthcare 691-699.
11. Said HM, Ross C (2011). Riboflavin. Modern Nutrition in Health and Disease 11:325-330.
12. Bonjour JP (1980). Vitamins and alcoholism. V. Riboflavin, VI. Niacin, VII. Pantothenic acid, and VIII. Biotin. Int J Vitam Nutr Res 50: 425-40. PMID: 7009467
13. Rosenthal WS, Adham NF, Lopez R, Cooperman JM (1973). Riboflavin deficiency in complicated chronic alcoholism. Am J Clin Nutr 26: 858-60. PMID: 4541718
14. Fernandez-Banares F, Abad-Lacruz A, Xiol X, Gine JJ, Dolz C, Cabre E, et al (1989). Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 84: 744-48. PMID: 2500847
15. Kuroki F, Iida M, Tominaga M, Matsumoto T, Hirakawa K, Sugiyama S, et al (1993). Multiple Vitamin Status in Crohn's Disease: Correlation with Disease Activity. Dig Dis Sci 38:1614-18. PMID: 8359072
16. Bosch AM, Abeling NG, Ijlst L, Knoester H, van der Pol Wl, Stroomer AE, et al (2011). Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment. J Inherit Metab Dis 34:159-64. doi: 10.1007/s10545-010-9242-z PMID: 21110228
17. Green P, Wiseman M, Crow YJ, Houlden H, Riphagen S, lin JP, et al (2010). Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54. Am J Hum Genet 86: 485-89. doi: 10.1016/j.ajhg.2010.02.006 PMID: 20206331
18. Ho G, Yonezawa A, Masuda S, Inui K, Sim KG, Carpenter K, et al (2011). Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B. Hum Mutat 32: E1976-84. doi: 10.1002/humu.21399 PMID: 21089064
19. Johnson JO, Gibbs JR, Megarbane A, Urtizberea JA, Hernandez DG, Foley AR, et al (2012). Exome sequencing reveals riboflavin transporter mutations as a cause of motor neuron disease. Brain 185: 2875-82.
20. Kodentsova VM, Vrzhesinskaia OA, Trofimenko EV, Sokonikov AA, Beketova NA, Blazheevich NV, et al (1994). [Vitamin status of children with diabetes mellitus]. Vopr Med Khim 40: 45-8.
21. Law LK, Tang NL, Hui J, Fung SL, Ruiter J, Wanders RJ, et al (2009). Novel mutations in ETFDH gene in Chinese patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. Clin Chim Acta 404: 95-9. doi: 10.1016/j.cca.2009.02.015 PMID: 19265687
22. Zhu M, Zhu X, Qi X, Weijiang D, Yu Y, Wan H, et al (2014). Riboflavin-responsive multiple Acyl-CoA dehydrogenation deficiency in 13 cases, and a literature review in mainland Chinese patients. J Hum Genet 59: 256-61. doi: 10.1038/jhg.2014.10 PMID: 24522293
23. Betz AL, Ren XD, Ennis SR, Hultquist DE (1994). Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir Suppl (Wien) 60: 314-17.
24. Said HM (2011). Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437: 357-72. doi: 10.1042/BJ20110326 PMID: 21749321
25. Said HM, Trebble T (2015). Intestinal digestion and absorption of micronutrients. In: Slesenger and Fordtran GI and Liver Disease; Feldman M, Friedman L, and Brandt L, editors; 10th edition; Elsevier publishing; pp 1765-88.
26. Subramanian VS, Subramanya SB, Rapp L, Marchant JS, Ma TY, Said HM (2011). Differential expression of human riboflavin transporters-1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. Biochim Biophys Acta 1808: 3016-21. doi: 10.1016/j.bbamem.2011.08.004 PMID: 21854757
27. Yao Y, Yonezawa A, Yoshimatsu H, Masuda S, Katsura T, Inui K (2010). Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. J Nutr 140: 1220-26. doi: 10.3945/jn.110.122911 PMID: 20463145
28. Yonezawa A, Inui K- I (2013). Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic disease. Mol Aspects Med 34: 693-701. doi: 10.1016/j.mam.2012.07.014 PMID: 23506902
29. Said HM, Ma TY(1994). Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am J Physiol 266: G15-21. PMID: 8304455
30. Said HM, Ortiz A, Moyer MP, Yanagawa N (2000). Riboflavine uptake by human-derived colonic epithelial NCM460 cells. Am J Physiol 278: C270-76.
31. Said HM, Mohammadkhani R (1993). Uptake of riboflavin across the brush border membrane of rat intestine: regulation by dietary vitamin levels. Gastroenterol 105: 1294-98.
32. Kumar CK, Yanagawa N, Ortiz A, Said HM (1998). Mechanism and regulation of riboflavin uptake by human renal proximal tubule epithelial cell line HK-2. Am J Physiol 274: F104-10. PMID: 9458829
33. Said HM, Wang S, Ma TY (2005). Mechanism of riboflavine uptake by cultured human retinal pigment epithelial ARPE-19 cells: possible regulation by an intracellular Ca2+ -calmodulin-mediated pathway. J Physiol 566.2: 369-77.
34. Subramanian VS, Ghosal A, Subramanya SB, Lytle C, Said HM (2013). Differentiation-dependent regulation of intestinal vitamin B2 uptake: Studies utilizing human derived intestinal epithelial Caco-2 cells and native rat intestine. Am J Physiol Gastrointest Liver Physiol 304:G741-48. doi: 10.1152/ajpgi.00018.2013 PMID: 23413253
35. Subramanian VS, Subramanya BS, Ghosal A, Said H M (2013). Chronic alcohol feeding inhibits physiological and molecular parameters of intestinal and renal riboflavin transport. Am J Physiol 305:C539-46.
36. Aydemir F, Jenkitkasemwong S, Gulec S, Knutson MD (2009). Iron loading increase ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages. J Nutr 139: 434-38. doi: 10.3945/jn.108.094052 PMID: 19141705
37. Elferink CJ, Reiners JJ Jr (1996). Quantitative RT-PCR on CYP1A1 heterogeneous nuclear RNA: a surrogate for the in vitro transcript run-on assay. Biotechniques 20: 470-77. PMID: 8679208
38. Livek KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta DeltaC(T)) method. Methods 25: 402-08, 2001. PMID: 11846609
39. Ghosal A, Sabui S, Said HM (2015). Identification and characterization of the minimal 5′-regulatory region of the human riboflavin transporter-3 (SLC52A3) in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 308: C189-96.
40. Tumer E, Broer A, Balakrishna S, Julich T, Broer S (2013). Enterocyte-specific Regulation of the Apical Nutrient Transporter SLC6A19 (B0 AT1) by Transcriptional and Epigenetic Networks. J Biol Chem 288: 33813-23. doi: 10.1074/jbc.M113.482760 PMID: 24121511
41. D'Addario C, Johansson S, Candeletti S, Romualdi P, Ogren SO, Terenius L, et al (2011). Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line. FASEB J 25: 1069-75. doi: 10.1096/fj.10-168534 PMID: 21106935
42. Li B, Carey M, Workman JL (2007). The role of chromatin during transcription. Cell 128, 707-19. PMID: 17320508
43. Srinivasan P, Subramanian VS, Said HM (2013). Effect of the cigarette smoke component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), on physiological and molecular parameters of thiamin uptake by pancreatic acinar cells. PLoS one 8:e78853. doi: 10.1371/journal.pone.0078853 PMID: 24244374
44. Jorgensen TN, Chritensen PM, Gether U (2014). Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochem Int 73: 107-112. doi: 10.1016/j.neuint.2014.01.005 PMID: 24462583
45. Naggar H, Van Ells TK, Ganapathy V, Smith SB (2005). Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate. Curr Eye Res 30: 35-44. PMID: 15875363
46. Tanaka K, Yamamoto A, Fujita T (2005). Functional expression and adaptive regulation of Na+-dependent neutral amino acid transporter SNAT2.ATA2 in normal human astrocytes under amino acid starved condition. Neurosci Lett 378: 70-75. PMID: 15774260