Differentiation-dependent regulation of intestinal vitamin B2 uptake: Studies utilizing human-derived intestinal epithelial Caco-2 cells and native at intestine

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 304, Issue 8, 2013, Pages

  Subramanian, Veedamali S ^a,b   Ghosal, Abhisek ^a,b   Subramanya, Sandeep B ^a,b   Lytle, Christian ^c   Said, Hamid M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell differentiation; Intestinal transport; RFVT 1; RFVT 3; Riboflavin

Indexed keywords

HETEROGENEOUS NUCLEAR RNA; MESSENGER RNA; PROTEIN; RIBOFLAVIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL STRAIN CACO 2; CONTROLLED STUDY; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 84878604795     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00018.2013     Document Type: Article

References (50)

1. Anand G, Hasan N, Jayapal S, Huma Z, Ali T, Hull J, Blair E, McShane T, Jayawant S. Early use of high-dose riboflavin in a case of Brown-Vialetto-Van Laere syndrome. Dev Med Child Neurol 54: 187-189, 2012.
2. Aydemir F, Jenkitkasemwong S, Gulec S, Knutson MD. Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages. J Nutr 139: 434-438, 2009.
3. Betz AL, Ren XD, Ennis SR, Hultquist DE. Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir Suppl (Wien) 60: 314-317, 1994.
4. +-dependent sugar transport in Caco-2 cells and human fetal colon. J Membr Biol 99: 113-125, 1987.
5. Bonjour JP. Vitamins and alcoholism. V. Riboflavin. VI. Niacin. VII. Pantothenic acid. VIII. Biotin. Int J Vitam Nutr Res 50: 425-440, 1980.
6. Bosch AM, Abeling NG, Ijlst L, Knoester H, van der Pol WL, Stroomer AE, Wanders RJ, Visser G, Wijburg FA, Duran M, Waterham HR. Brown-Vialetto-Van Laere and Fazio-Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment. J Inherit Metab Dis 34: 159-164, 2011.
7. Costa C, Huneau JF, Tome D. Characteristics of L-glutamine transport during Caco-2 cell differentiation. Biochim Biophys Acta 1509: 95-192, 2000.
8. Cooperman JM, Lopez R. Riboflavin. In: Handbook of Vitamins: Nutritional, Biochemical and Clinical Aspects, edited by Machlin LJ. New York: Dekker, 1984, p. 299-327.
9. Dipti S, Child AM, Livingston JH, Aggarwal AK, Miller M, Williams C, Crow YJ. Brown-Vialetto-Van Laere syndrome: variability in age at onset and disease progression highlighting the phenotype overlap with Fazio-Londe disease. Brain Dev 27: 443-446, 2005.
10. Elferink CJ, Reiners JJ Jr. Quantitative RT-PCR on CYP1A1 heterogeneous nuclear RNA: a surrogate for the in vitro transcript run-on assay. Biotechniques 20: 470-477, 1996.
11. Fan MZ, Matthews JC, Etienne NM, Stoll B, Lackeyram D, Burrin DG. Expression of apical membrane L-glutamate transporters in neonatal porcine epithelial cells along the small intestinal crypt-villus axis. Am J Physiol Gastrointest Liver Physiol 287: G385-G398, 2004.
12. Fernandez-Banares F, Abad-Lacruz A, Xiol X, Gine JJ, Dolz C, Cabre E, Esteve M, Gonzalez-Huix F, Gassull MA. Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 84: 744-748, 1989.
13. Fujimura M, Yamamoto S, Murata T, Yasujima T, Inoue K, Ohta KY, Yuasa H. Functional characteristics of the human ortholog of riboflavin transporter 2 and riboflavin-responsive expression of its rat ortholog in the small intestine indicate its involvement in riboflavin absorption. J Nutr 140: 1722-1727, 2010.
14. Goldsmith GA. Riboflavin deficiency. In: Riboflavin, edited by Rivlin R. New York: Plenum, 1975, p. 221-224.
15. Green P, Wiseman M, Crow YJ, Houlden H, Riphagen S, Lin JP, Raymond FL, Childs AM, Sheridan E, Edwards S, Josifova DJ. Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54. Am J Hum Genet 86: 485-489, 2010.
16. He Y, Ye L, Shan B, Song G, Meng F, Wang S. Effect of riboflavinfortified salt nutrition intervention on esophageal squamous cell carcinoma in a high incidence area, China. Asian Pac J Cancer 10: 619-622, 2009.
17. Hidalgo IJ, Raub TJ, Borchardt RT. Characterzation of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96: 736-749, 1989.
18. Hopfer U, Nelson K, Perrotto J, Isselbacher KJ. Glucose transport in isolated brush border membrane from rat small intestine. J Biol Chem 248: 25-32, 1973.
19. Kodentsova VM, Vrzhesinskaia OA, Sokol'nikov AA, Kharitonchik LA, Spirichev VB. [Metabolism of B group vitamins in patients with insulin-dependent and non-insulin-dependent forms of diabetes mellitus]. Vopr Med Khim 39: 26-29, 1993.
20. Kohler CU, Roos PH. Focus on the intermediate state: immature mRNA of cytochrome P450-methods and insights. Anal Bioanal Chem 392: 1109-1122, 2008.
21. -ΔΔcτ method. Methods 25: 402-408, 2001.
22. Mariadason JM, Nicolas C, L'Italien KE, Zhuang M, Smartt HJ, Heerdt BG, Yang W, Corner GA, Wilson AJ, Klampfer L, Arango D, Augenlicht LH. Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis. Gastroenterology 128: 1081-1088, 2005.
23. Maulen NP, Henriquez EA, Kempe S, Carcamo JG, Schmid-Kotsa A, Bachem Grunert A, Bustamante ME, Nualart F, Vera JC. Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated Caco-2 cells. J Biol Chem 278: 9035-9041, 2003.
24. McShane MA, Boyd S, Harding B, Brett EM, Wilson J. Progressive bulbar paralysis of childhood. A reappraisal of Fazio-Londe disease. Brain 115: 1889-1900, 1992.
25. Mordrelle A, Jullian E, Costa C, Cormet-Boyaka E, Benamouzig R, Tome D, Huneau JF. EAAT1 is involved in transport of L-glutamate during differentiation of the Caco-2 cell line. Am J Physiol Gastrointest Liver Physiol 279: G366-G373, 2000.
26. Nabokina SM, Reidling JC, Said HM. Differentiation-dependent upregulation of intestinal thiamin uptake: cellular and molecular mechanisms. J Biol Chem 280: 32676-32682, 2005.
27. Nabokina SM, Subramanian VS, Said HM. Effect of clinical mutations on functionality of the human riboflavin transporter-2 (hRFT-2). Mol Genet Metab 105: 652-657, 2012.
28. Pangrekar J, Krishnaswamy K, Jagadeesan V. Effects of riboflavin deficiency and riboflavin administration on carcinogen-DNA binding. Food Chem Toxicol 31: 745-750, 1993.
29. Pinkus LM. Separation and use of enterocytes. Methods Enzymol 77: 154-162, 1981.
30. Pinto J, Huang YP, Rivlin RS. Inhibition of riboflavin metabolism in rat tissue by chloropromazine, imipramine, and amitriptyline. J Clin Invest 67: 1500-1506, 1981.
31. Pelliccione M, Pinto J, Huang YP, Rivlin RS. Acceleration of development of riboflavin deficiency by treatment with chloropromazine. Biochem Pharmacol 32: 2949-2953, 1983.
32. Rosenthal WS, Adham NF, Lopez R, Cooperman JM. Riboflavin deficiency in complicated chronic alcoholism. Am J Clin Nutr 26: 858-860, 1973.
33. Said HM, Ross C. Riboflavin. In: Modern Nutrition in Health and Disease (11th ed.), edited by Ross C, Caballero B, Cousins RJ, Tucker KL, Ziegler TR. New York: Lippincott Williams and Wilkins, 2011, p. 325-330.
34. Said HM, Nexo E. Intestinal absorption of water-soluble vitamins. In: Physiology of the Gastrointestinal Tract (5th ed.), edited by Johnson LR, Ghishan FK, Merchand JL, Said HM, Wood JD. San Diego, CA: Elsevier, 2012, p. 1711-1756.
35. Said HM. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437: 357-372, 2011.
36. Said HM, Ma TY. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 266: G15-G21, 1994.
37. Said HM, Nguyen TT, Dyer DL, Cowan KH, Rubin SA. Interstinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA. Biochim Biophys Acta 1281: 164-172, 1996.
38. Siassi F, Ghadirian P. Riboflavin deficiency and esophageal cancer: a case control-household study in the Caspian Littoral of Iran. Cancer Detect Prev 29:464-469, 2005.
39. Subramanian VS, Reidling JC, Said HM. Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine. Am J Physiol Cell Physiol 295: C828-C835, 2008.
40. Subramanian VS, Subramanya SB, Rapp L, Marchant JS, Ma TY, Said HM. Differential expression of human riboflavin transporters-1,-2, and-3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. Biochim Biophys Acta 1808: 3016-3021, 2011.
41. Subramanya SB, Subramanian VS, Said HM. Chronic alcohol consumption and intestinal thiamin absorption: effect of physiological and molecular parameters of the uptake process. Am J Physiol Gastrointest Liver Physiol 299: G23-G31, 2010.
42. Subramanya SB, Subramanian VS, Kumar SJ, Hoiness R, Said HM. Inhibition of intestinal biotin absorption by chronic alcohol feeding: cellular and molecular mechanisms. Am J Physiol Gastrointest Liver Physiol 300: G494-G501, 2011.
43. Subramanya SB, Subramanian VS, Sekar VT, Said HM. Thiamin uptake by pancreatic cells: effect of chronic alcohol feeding/exposure. Am J Physiol Gastrointest Liver Physiol 301: G896-G904, 2011.
44. Vachon PH, Beaulieu JF. Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line. Gastroenterology 103: 414-423, 1992.
45. Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, Zhang LQ, Yang JZ, Li JL, Li XC, Ren JL, Liu ZC, Gao WJ, Yuan L, Wei W, Zhang YR, Wang WP, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Ku JW, Fan ZM, Zhou SL, Guo ZG, Zhao XK, Liu N, Ai YH, Shen FF, Cui WY, Song S, Guo T, Huang J, Yuan C, Huang J, Wu Y, Yue WB, Feng CW, Li HL, Wang Y, Tian JY, Lu Y, Yuan Y, Zhu WL, Liu M, Fu WJ, Yang X, Wang HJ, Han SL, Chen J, Han M, Wang HY, Zhang P, Li XM, Dong JC, Xing GL, Wang R, Guo M, Chang ZW, Liu HL, Guo L, Yuan ZQ, Liu H, Lu Q, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Qige Q, Bai LT, Yang WJ, Lei GY, Shen ZY, Chen LQ, Li EM, Xu LY, Wu ZY, Cao WK, Wang JP, Bao ZQ, Chen JL, Ding GC, Zhuang X, Zhou YF, Zheng HF, Zhang Z, Zuo XB, Dong ZM, Fan DM, He X, Wang J, et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet 42: 759-763, 2010.
46. Weiser MM. Intestinal epithelial cell surface membrane glycoprotein synthesis. J Biol Chem 248: 2536-2541, 1973.
47. Wong WK, Chen K, Shih JC. Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. J Biol Chem 278: 36227-36235, 2003.
48. Yamamoto S, Inoue K, Ohta KY, Fukatsu R, Maeda JY, Yoshida Y, Yuasa H. Identification and functional characterization of rat riboflavin transporter 2. J Biochem 145: 437-443, 2009.
49. Yao Y, Yonezawa A, Yoshimatsu H, Masuda S, Katsura T, Inui K. Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. J Nutr 140: 1220-1226, 2010.
50. Yonezawa A, Masuda S, Katsura T, Inui K. Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1. Am J Physiol Cell Physiol 295: C632-C641, 2008.