Riboflavin (vitamin B-2) reduces hepatocellular injury following liver ischaemia and reperfusion in mice

Food and Chemical Toxicology

Volumn 67, Issue , 2014, Pages 65-71

  Sanches, Sheila Cristina ^a   Ramalho, Leandra Naira Z ^a   Mendes Braz, Mariana ^a   Terra, Vânia Aparecida ^b   Cecchini, Rubens ^b   Augusto, Marlei Josiele ^a   Ramalho, Fernando Silva ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Inflammation; Ischaemia reperfusion; Nitric oxide; Oxidative stress; Riboflavin

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MYELOPEROXIDASE; RIBOFLAVIN; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; LIVER CELL DAMAGE; LIVER ISCHEMIA; LIVER PROTECTION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; REPERFUSION INJURY; ANIMAL; COMPLICATION; ISCHEMIA; LIVER DISEASE; PATHOLOGY; REPERFUSION;

ANIMALS; ISCHEMIA; LIVER DISEASES; MICE; REPERFUSION; RIBOFLAVIN;

EID: 84896028332     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.02.013     Document Type: Article

References (29)

1. Altaş S., Kizil G., Kizil M., et al. Protective effect of Diyarbakir watermelon juice on carbon tetrachloride-induced toxicity in rats. Food Chem. Toxicol. 2011, 49:2433-2438.
2. Betz A., Ren X.D., Ennis S.R., et al. Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir. Suppl. (Wien) 1994, 60:314-317.
3. Brigelius R., Muckel C., Akerboom T.P., et al. Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide. Biochem. Pharmacol. 1983, 32:2529-2534.
4. Casillas-Ramírez A., Mosbah I.B., Ramalho F., et al. Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation. Life Sci. 2006, 79:1881-1894.
5. Hultquist D.E., Xu F., Quandt K.S., et al. Evidence that NADPH-dependent methemoglobin reductase and administered riboflavin protect tissues from oxidative injury. Am. J. Hematol. 1993, 42:13-18.
6. Ivey C.L., Williams F.M., Collins P.D., et al. Neutrophil chemoattractants generated in two phases during reperfusion of ischaemia myocardium in the rabbit: evidence for a role for C5a and interleukin-8. J. Clin. Invest. 1995, 95:2720-2728.
7. Iwanaga K., Hasegawa T., Hultiquist D.E., et al. Riboflavin-mediated reduction of oxidant injury, rejection and vasculopathy after cardiac allotransplantation. Transplantation 2007, 83:747-753.
8. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 284:15-26.
9. Jaeschke H. Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G1083-G1088.
10. Jaeschke H., Smith C.W. Mechanisms of neutrophil-induced parenchymal cell injury. J. Leukoc. Biol. 1997, 61:647-653.
11. 2 chemiluminescence method. J. Biol. Chem. 1993, 268:23106-23110.
12. 2 on the productions of proinflammatory cytokine and NO in endotoxin-induced shock in mice. Life Sci. 2005, 78:134-139.
13. Kotegawa M., Sugiyama M., Haramaki N. Protective effects of riboflavin and its derivatives against ischemic reperfused damage of rat heart. Biochem. Mol. Biol. Int. 1994, 34:685-691.
14. Mack C., Hulquist D.E., Shlafer M. Myocardial flavin reductase and riboflavin: a potential role in decreasing reoxygenation injury. Biochem. Biophys. Res. Commun. 1995, 212:35-40.
15. Manthey K.C., Rodriguez-Melendez R., Hoi J.T., et al. Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. J. Nutr. Biochem. 2006, 17:250-256.
16. Marklund S., Marklund G. Involvement of the superoxide anion radical in the antioxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
17. Mendes-Braz M., Elias-Miró M., Jiménez-Castro M.B., et al. The current state of knowledge of hepatic ischemia-reperfusion injury based on its study in experimental models. J. Biomed. Biotechnol. 2012, 2012:298657.
18. Moloney W.C., Mcpherson K., Fliegelman L. Esterase activity in leukocytes demonstrated by the use of naphthol AS-D chloroacetate substrate. J. Histochem. Cytochem. 1960, 8:200-207.
19. Powers H.J. Riboflavin (vitamin B-2) and health. Am. J. Clin. Nutr. 2003, 77:1352-1360.
20. Qureshi N., Perera P.Y., Shen J., et al. The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events. J. Immunol. 2003, 171:1515-1525.
21. Qureshi N., Vogel S.N., Van Way C., et al. The proteasome: a central regulator of inflammation and macrophage function. Immunol. Res. 2005, 31:243-260.
22. Qureshi A.A., Tan X., Reis J.C., et al. Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models. Lipids Health Dis. 2011, 10:177.
23. Scholz R.W., Reddy P.V., Wynn M.K., et al. Glutathione-dependent factors and inhibition of rat liver microsomal lipid peroxidation. Free Radic. Biol. Med. 1997, 23:815-828.
24. 2 against oxidant-mediated acute lung injury. Inflammation 1999, 23:449-460.
25. Serafin A., Rosello-Catafau J., Prats N., et al. Ischemic preconditioning increases the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat. Am. J. Pathol. 2002, 161:587-601.
26. Shih C.K., Chen C.M., Chen C.Y., et al. Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25. Food Chem. Toxicol. 2010, 48:1913-1918.
27. Terra V.A., Souza-Neto F.P., Pereira R.C., et al. Nitric oxide is responsible for oxidative skin injury and modulation of cell proliferation after 24h of UVB exposures. Free Radic. Res. 2012, 46:872-882.
28. 2 presents a promising therapeutic strategy for sepsis and septic shock. Infect. Immun. 2004, 72:1820-1823.
29. Xu F., Hultquist D.E. Coupling of dihydroriboflavin oxidation to the formation of the higher valence states of hemeproteins. Biochem. Biophys. Res. Commun. 1991, 181:197-203.