Riboflavin-mediated reduction of oxidant injury, rejection, and vasculopathy after cardiac allotransplantation

Transplantation

Volumn 83, Issue 6, 2007, Pages 747-753

  Iwanaga, Koichiro ^a   Hasegawa, Tomomi ^a   Hultquist, Donald E ^b   Harada, Hiroaki ^a   Yoshikawa, Yasushi ^a   Yanamadala, Sunitha ^a   Liao, Hui ^a   Visovatti, Scott H ^a   Pinsky, David J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b OBERLIN COLLEGE   (United States)

Author keywords

Antioxidant; Cardiac allograft; Donor reactive alloantibodies; Ischemia; Reperfusion

Indexed keywords

ALLOANTIBODY; RIBOFLAVIN;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC ALLOGRAFT VASCULOPATHY; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; GRAFT SURVIVAL; HEART INFARCTION; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; LIPID PEROXIDATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CORONARY DISEASE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GRAFT REJECTION; HEART TRANSPLANTATION; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; OXIDANTS; OXIDATIVE STRESS; REPERFUSION INJURY; RIBOFLAVIN; TRANSPLANTATION, HOMOLOGOUS; VITAMIN B COMPLEX;

EID: 34147101846     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000256283.06469.d4     Document Type: Article

References (35)

1. Taylor DO, Edwards LB, Boucek MM, et al. The Registry of the International Society for Heart and Lung Transplantation: Twentyfirst official adult heart transplantation report-2004. J Heart Lung Transplant 2004; 23: 796.
2. Hosenpud JD. Immune mechanisms of cardiac allograft vasculopathy: an update. Transpl Immunol 1993; 1: 237.
3. Wang CY, Aronson I, Takuma S, et al. cAMP pluse during preservation inhibits the late development of cardiac isograft and allograft vasculopathy. Circ Res 2000; 86: 982.
4. Murata S, Miniati DN, Kown MH, et al. Superoxide dismutase mimetic M40401 reduces ischemia-reperfusion injury and graft coronary artery disease in rodent cardiac allografts. Transplantation 2004; 78: 1166.
5. Vassalli G, Gallino A, Weis M, et al. Working Microcirculation of the European Society of Cardiology. Alloimmunity and nonimmunologic risk factors in cardiac allograft vasculopathy. Eur Heart J 2003; 24: 1180.
6. Hultquist DE, Xu F, Quandt KS, et al. Evidence that NADPH-dependent methemoglobin reductase and administered riboflavin protect tissues from oxidative injury. Am J Hematol 1993; 42: 13.
7. Ogura R, Katsuki T, Daoud AH, Griffin AC. Anti-oxidative effects of vitamin B2-butyrate on the cardiac mitochondrial disorders induced by adriamycin. J Nutr Sci Vitaminol (Tokyo) 1982; 28: 329.
8. Seekamp A, Hultquist DE, Till GO. Protection by vitamin B2 against oxidant-mediated acute lung injury. Inflammation 1999; 23: 449.
9. Mack CP, Hultquist DE, Shlafer M. Myocardial flavin reductase and riboflavin: a potential role in decreasing reoxygenation injury. Biochem Biophys Res Commun 1995; 212: 35.
10. Kotegawa M, Sugiyama M, Haramaki N. Protective effects of riboflavin and its derivaties against ischemic reperfusioned damage of rat heart. Biochem Mol Biol Int 1994; 34: 685.
11. Betz AL, Ren XD, Ennis SR, Hultquist DE. Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir Suppl (Wien) 1994; 60: 314.
12. Toyosawa T, Suzuki M, Kodama K, Araki S. Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock. Infect Immun 2004; 72: 1820.
13. Ono K, Lindsay ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225.
14. Wang CY, Naka Y, Liao H, et al. Cardiac graft intercellular adhesion molecule-1 (ICAM-1) and interleukin-1 expression mediate primary isograft failure and induction of ICAM-1 in organs remote from the site of transplantation. Circ Res 1998; 82: 762.
15. Niimi M. The technique for heterotopic cardiac transplantation in mice: experience of 3000 operations by one surgeon. J Heart Lung Transplant 2001; 20: 1123.
16. Wang CY, Mazer SP, Minamoto K, et al. Suppression of murine cardiac allograft arteriopathy by long-term blocade of CD40-CD154 interactions. Circulation 2002; 105: 1609.
17. Okada M, Wang CY, Hwang DW, et al. Transcriptional control of cardiac allograft vasculopathy by early growth response gene-1 (Egr-1). Circ Res 2002; 91: 135.
18. Goldblum SE, Wu K-M, Jay M. Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J Appl Physiol 1985; 59: 1978.
19. Pelletier RP, Adams PW, Hennessy PK, Orosz CG. Comparison of crossmatch results obtained by ELISA, flow cytometry, and conventional methodologies. Hum Immunol 1999; 60: 855.
20. Hess ML, Kukreja RC. Free radicals, calcium homeostasis, heat shock proteins, and myocardial stunning. Ann Thorac Surg 1995; 60: 760.
21. Minamoto K, Pinsky DJ, Fujita T, Naka Y. Timing of nitric oxide donor supplementation determines endothelin-1 regulation and quality of lung preservation for transplantation. Am J Respir Cell Mol Biol 2002; 26: 14.
22. Tanaka M, Mokhtari GK, Terry RD, et al. Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts. Circulation 2004; 110: II 200.
23. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. J Immunol 1994; 152: 5135.
24. Das DK, Maulik N. Antioxidant effectiveness in ischemia-reperfusion tissue injury. Methods Enzymol 1994; 233: 601.
25. Hultquist DE, Mack CP, Quandt KS, et al. Studies of the mechanism by which riboflavin and pyrroloquinoline quinone protect tissues from reoxygenation injury. In Davies KJA, Ursini F, eds. The Oxygen Paradox. Padova, Italy: CLEUP University Press: 1995:731.
26. Shalloe F, Elliott G, Ennis O, Mantle TJ. Evidence that biliverdin-IX beta reductase and flavin reductase are identical. Biochem J 1996; 316: 385.
27. Sedlak TW, Snyder SH. Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 2004; 113: 1776.
28. Jung FJ, Yang L, Harter L, et al. Melatonin in vivo prolongs cardiac allograft survival in rats. J Pineal Res 2004; 37: 36.
29. Novogrodsky A, Ravid A, Rubin AL, Stenzel KH. Hydroxyl radical scavengers inhibit lymphocyte mitogenesis. Proc Natl Acad Sci USA 1982; 79: 1171.
30. Chaudhri G, Clark IA, Hunt NH, et al. Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation. J Immunol 1986; 137: 2649.
31. Gao D, Lunsford KE, Eiring AM, Bumgardner GL. Critical role for CD8 T cells in allograft acceptance induced by DST and CD40/CD154 costimulatory blockade. Am J Transplant 2004; 4: 1061.
32. Hancock WW, Buelow R, Sayegh MH, Yurka LA. Antibody-induced transplant arteriosclerosis is prevented by graft expression of antioxidant and anti-apoptotic genes. Nat Med 1998; 4: 1392.
33. Furukawa Y, Libby P, Stinn JL, et al. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in nonimmunosuppressed hosts. Am J Pathol 2002; 160: 1077.
34. McNulty H, Dowey le RC, Strain JJ, et al. Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C→T polymorphism. Circulation 2006; 113: 74.
35. Allard ML, Jeejeebhoy KN, Sole MJ. The management of conditioned nutritional requirements in heart failure. Heart Fail Rev 2006; 11: 75.