Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase

Biochemistry

Volumn 54, Issue 30, 2015, Pages 4692-4703

  Decroos, Christophe ^a   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; AMINO ACIDS; CATALYSIS; ENZYME INHIBITION; NUCLEIC ACIDS; QUANTUM CHEMISTRY; SYNTHESIS (CHEMICAL); ZINC;

CATALYTIC MECHANISMS; DEACETYLASE INHIBITOR; HIGH RESOLUTION CRYSTAL STRUCTURE; HISTONE DEACETYLASES; TETRAHEDRAL INTERMEDIATES; TRIFLUOROMETHYLKETONE; VERY HIGH RESOLUTION; X RAY CRYSTAL STRUCTURES;

CRYSTAL STRUCTURE;

ACETYLPOLYAMINE AMIDOHYDROLASE DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; POLYAMINE DEACETYLASE INHIBITOR; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG; ACETYLPOLYAMINE AMIDOHYDROLASE; BACTERIAL PROTEIN; ENZYME INHIBITOR; HYDROLASE; ZINC;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME MECHANISM; IC50; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BRUCELLACEAE; CHEMISTRY; ENZYMOLOGY; HUMAN; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

MYCOPLANA RAMOSA;

AMINOHYDROLASES; BACTERIAL PROTEINS; BRUCELLACEAE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; PROTEIN STRUCTURE, TERTIARY; ZINC;

EID: 84938633786     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00536     Document Type: Article

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