Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 15, 2013, Pages 4530-4540

  Decroos, Christophe ^a   Bowman, Christine M ^a   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Enzyme inhibitor; Metalloenzyme; Polyamine analogues; Polyamine deacetylase

Indexed keywords

5 [(3 AMINOPROPYL)AMINO]PENTANE 1 THIOL; 5 [(3 AMINOPROPYL)AMINO]PENTYLBORONIC ACID; 6 [(3 AMINOPROPYL)AMINO] N HYDROXYHEXANAMIDE; 6 [(3 AMINOPROPYL)AMINO]HEXANOIC ACID; 7 [(3 AMINOPROPYL)AMINO] 1 METHOXYHEPTAN 2 ONE; 7 [(3 AMINOPROPYL)AMINO] 1,1,1 TRIFLUOROHEPTAN 2 ONE; 7 [(3 AMINOPROPYL)AMINO]HEPTAN 2 ONE; 7 [[(3 AMINOPROPYL)AMINO] 2 OXOHEPTYL]THIOACETATE; [5 [(3 AMINOPROPYL)AMINO]PENTYL]THIOACETATE; ACETONE; ACETYLPOLYAMINE AMIDOHYDROLASE; AMIDASE; AMIDOHYDROLASE INHIBITOR; HYDROXAMIC ACID; N [5 (METHYLSULFONYL)PENTYL]PROPANE 1,3 DIAMINE; N8 ACETYLSPERMIDINE; TRIFLUOROMETHYL KETONE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; EUKARYOTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROKARYOTE;

BACTERIA (MICROORGANISMS); EUKARYOTA; MYCOPLANA RAMOSA; PROKARYOTA;

EID: 84879689689     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.045     Document Type: Article

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