Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 31, 2015, Pages E4264-E4271

  Murata, Yoji ^a   Kotani, Takenori ^a   Supriatna, Yana ^b   Kitamura, Yasuaki ^a   Imada, Shinya ^a   Kawahara, Kohichi ^c   Nishio, Miki ^c   Daniwijaya, Edwin Widyanto ^a   Sadakata, Hisanobu ^b   Kusakari, Shinya ^b   Mori, Munemasa ^b   Kanazawa, Yoshitake ^b   Saito, Yasuyuki ^a   Okawa, Katsuya ^d   Takeda Morishita, Mariko ^e   Okazawa, Hideki ^a   Ohnishi, Hiroshi ^b   Azuma, Takeshi ^a   Suzuki, Akira ^c   Matozaki, Takashi ^a,b  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KYOWA HAKKO KOGYO CO LTD   (Japan)

^e KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Colitis; Intestinal epithelial cells; Intestinal immunity; Protein tyrosine phosphatase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 20; CELL ADHESION MOLECULE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MEMBRANE PROTEIN; PROTEIN KINASE C; PROTEIN KINASE SYK; PROTEIN TYROSINE PHOSPHATASE; STOMACH CANCER ASSOCIATED PROTEIN TYROSINE PHOSPHATASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CEACAM20 PROTEIN, MOUSE; CHEMOKINE; MESSENGER RNA; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN TYROSINE KINASE; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; SAP-1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CELL CULTURE; COLITIS; DISEASE ACTIVITY; DISEASE SEVERITY; EPITHELIUM HYPERPLASIA; FEMALE; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; INCIDENCE; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROADENOMA; MICROVILLUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECTUM PROLAPSE; REGULATORY MECHANISM; SMALL INTESTINE; STOMACH; UPREGULATION; ANIMAL; CELL COUNT; COLON; DEFICIENCY; ENZYMOLOGY; GENETICS; GOBLET CELL; HEK293 CELL LINE; HUMAN; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; SRC HOMOLOGY DOMAIN;

ANIMALIA; MAMMALIA; MUS;

ANIMALS; CELL ADHESION MOLECULES; CELL COUNT; CHEMOKINES; COLITIS; COLON; FEMALE; GOBLET CELLS; HEK293 CELLS; HUMANS; INTERLEUKIN-10; INTESTINAL MUCOSA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; NF-KAPPA B; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN-TYROSINE KINASES; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 3; RNA, MESSENGER; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES;

EID: 84938632051     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1510167112     Document Type: Article

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