Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives

Microbial Cell Factories

Volumn 14, Issue 1, 2015, Pages

  Payero, Tamara D ^a,b   Vicente, Cláudia M ^a,b   Rumbero, Ángel ^c   Barreales, Eva G ^a   Santos Aberturas, Javier ^b,d   de Pedro, Antonio ^a   Aparicio, Jesús F ^a  

^a UNIVERSITY OF LEÓN   (Spain)

^b Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d JOHN INNES CENTRE   (United Kingdom)

Author keywords

Antifungal agent; Cytochrome P450 monooxygenase; Filipin biosynthesis; Filipin derivatives; Polyene macrolide; Streptomyces

Indexed keywords

1' HYDROXYFILIPIN I; BACTERIAL DNA; BACTERIAL PROTEIN; CYTOCHROME P450; FILIPIN; FILIPIN I; MACROLIDE; POLYENE; POLYKETIDE SYNTHASE; PROTEIN FILC; PROTEIN FILD; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BASE PAIRING; CYBERLINDNERA JADINII; CYCLIZATION; DNA ISOLATION; DNA SEQUENCE; DRUG HYDROXYLATION; DRUG SCREENING; DRUG SYNTHESIS; GENE CLUSTER; GENE DELETION; GENE DISRUPTION; GENE LOCATION; GENETIC CODE; GENETIC COMPLEMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROTEIN ASSEMBLY; QUANTUM YIELD; SACCHAROMYCES CEREVISIAE; STREPTOMYCES; STREPTOMYCES FILIPINENSIS; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS;

PICHIA JADINII; SACCHAROMYCES CEREVISIAE; STREPTOMYCES; STREPTOMYCES FILIPINENSIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CYTOCHROME P-450 ENZYME SYSTEM; FILIPIN; MOLECULAR SEQUENCE DATA; STREPTOMYCES;

EID: 84938599912     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-015-0307-4     Document Type: Article

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