Direct transcriptional reprogramming to nephron progenitors

Current Opinion in Genetics and Development

Volumn 34, Issue , 2015, Pages 10-16

  Vanslambrouck, J M ^a   Little, M H ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; NERVE CELL ADHESION MOLECULE; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; CELL RENEWAL; CELL SURVIVAL; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE EXPRESSION; HUMAN; KIDNEY TUBULE; KLF4 GENE; NEPHRON; NONHUMAN; NUCLEAR REPROGRAMMING; OCT4 GENE; ONCOGENE C MYC; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SOX2 GENE; STEM CELL; TRANSCRIPTIONAL REPROGRAMMING; GENETICS; GROWTH, DEVELOPMENT AND AGING; KIDNEY; METABOLISM;

CELL DIFFERENTIATION; CELLULAR REPROGRAMMING; HUMANS; KIDNEY; NEPHRONS; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 84938594234     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2015.06.001     Document Type: Review

References (61)

1. Cass A., Chadban S., Craig J., Howard J., McDonald S., Salkeld G., White S. The Economic Impact of End Stage Kidney Disease in Australia 2006, 9-59. Kidney Health Australia.
2. Care F.M. ESRD patients in 2013: a global perspective 2013.
3. National Chronic Kidney Disease Fact Sheet: General Information and National Estimates on Chronic Kidney Disease in the US 2014, Centers for Disease Control and Prevention (CDC).
4. Hoy W.E., Douglas-Denton R.N., Hughson M.D., Cass A., Johnson K., Bertram J.F. A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 2003, S31-S37.
5. Nyengaard J.R., Bendtsen T.F. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 1992, 232:194-201.
6. Al-Awqati Q., Oliver J.A. Stem cells in the kidney. Kidney Int 2002, 61:387-395.
7. Little M. Wilms' tumor: starting off the kidney all over again?. Prog Mol Subcell Biol 2005, 40:107-132.
8. Kobayashi A., Valerius M.T., Mugford J.W., Carroll T.J., Self M., Oliver G., McMahon A.P. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008, 3:169-181.
9. Hinchliffe S.A., Sargent P.H., Howard C.V., Chan Y.F., van Velzen D. Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest 1991, 64:777-784.
10. Rumballe B.A., Georgas K.M., Combes A.N., Ju A.L., Gilbert T., Little M.H. Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. Dev Biol 2011, 360:110-122.
11. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
12. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
13. Kim J.B., Zaehres H., Wu G., Gentile L., Ko K., Sebastiano V., Arauzo-Bravo M.J., Ruau D., Han D.W., Zenke M., et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 2008, 454:646-650.
14. Aasen T., Raya A., Barrero M.J., Garreta E., Consiglio A., Gonzalez F., Vassena R., Bilic J., Pekarik V., Tiscornia G., et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol 2008, 26:1276-1284.
15. Stadtfeld M., Nagaya M., Utikal J., Weir G., Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008, 322:945-949.
16. Loh Y.H., Agarwal S., Park I.H., Urbach A., Huo H., Heffner G.C., Kim K., Miller J.D., Ng K., Daley G.Q. Generation of induced pluripotent stem cells from human blood. Blood 2009, 113:5476-5479.
17. Lou X.X., Nakagawa T., Nishimura K., Ohnishi H., Yamamoto N., Sakamoto T., Ito J. Reprogramming of mouse cochlear cells by transcription factors to generate induced pluripotent stem cells. Cell Reprogram 2013, 15:514-519.
18. Montserrat N., Ramirez-Bajo M.J., Xia Y., Sancho-Martinez I., Moya-Rull D., Miquel-Serra L., Yang S., Nivet E., Cortina C., Gonzalez F., et al. Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors, OCT4 and SOX2. J Biol Chem 2012, 287:24131-24138.
19. Wang W.W., Wang W., Jiang Y., Han G.F., Lu S., Li G., Zhang J. Reprogramming of mouse renal tubular epithelial cells to induced pluripotent stem cells. Cytotherapy 2013, 15:578-585.
20. Zhou T., Benda C., Dunzinger S., Huang Y., Ho J.C., Yang J., Wang Y., Zhang Y., Zhuang Q., Li Y., et al. Generation of human induced pluripotent stem cells from urine samples. Nat Protoc 2012, 7:2080-2089.
21. Song B., Niclis J.C., Alikhan M.A., Sakkal S., Sylvain A., Kerr P.G., Laslett A.L., Bernard C.A., Ricardo S.D. Generation of induced pluripotent stem cells from human kidney mesangial cells. J Am Soc Nephrol 2011, 22:1213-1220.
22. Lam A.Q., Freedman B.S., Morizane R., Lerou P.H., Valerius M.T., Bonventre J.V. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol 2014, 25:1211-1225.
23. Mae S., Shono A., Shiota F., Yasuno T., Kajiwara M., Gotoda-Nishimura N., Arai S., Sato-Otubo A., Toyoda T., Takahashi K., et al. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun 2013, 4:1367.
24. Taguchi A., Kaku Y., Ohmori T., Sharmin S., Ogawa M., Sasaki H., Nishinakamura R. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 2014, 14:53-67.
25. Takasato M., Er P.X., Becroft M., Vanslambrouck J.M., Stanley E.G., Elefanty A.G., Little M.H. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat Cell Biol 2014, 16:118-126.
26. Xia Y., Nivet E., Sancho-Martinez I., Gallegos T., Suzuki K., Okamura D., Wu M.Z., Dubova I., Esteban C.R., Montserrat N., et al. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat Cell Biol 2013, 15:1507-1515.
27. Takasato M., Little M.H. Generating a self-organising kidney from pluripotent cells. Curr Opin Organ Transpl 2015, 142:1937-1947.
28. Han D.W., Tapia N., Hermann A., Hemmer K., Hoing S., Arauzo-Bravo M.J., Zaehres H., Wu G., Frank S., Moritz S., et al. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 2012, 10:465-472.
29. Kim J., Efe J.A., Zhu S., Talantova M., Yuan X., Wang S., Lipton S.A., Zhang K., Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A 2011, 108:7838-7843.
30. Marro S., Pang Z.P., Yang N., Tsai M.C., Qu K., Chang H.Y., Sudhof T.C., Wernig M. Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell 2011, 9:374-382.
31. Najm F.J., Lager A.M., Zaremba A., Wyatt K., Caprariello A.V., Factor D.C., Karl R.T., Maeda T., Miller R.H., Tesar P.J. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol 2013, 31:426-433.
32. Thier M., Worsdorfer P., Lakes Y.B., Gorris R., Herms S., Opitz T., Seiferling D., Quandel T., Hoffmann P., Nothen M.M., et al. Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 2012, 10:473-479.
33. Torper O., Pfisterer U., Wolf D.A., Pereira M., Lau S., Jakobsson J., Bjorklund A., Grealish S., Parmar M. Generation of induced neurons via direct conversion in vivo. Proc Natl Acad Sci U S A 2013, 110:7038-7043.
34. Yang N., Zuchero J.B., Ahlenius H., Marro S., Ng Y.H., Vierbuchen T., Hawkins J.S., Geissler R., Barres B.A., Wernig M. Generation of oligodendroglial cells by direct lineage conversion. Nat Biotechnol 2013, 31:434-439.
35. Huang P., He Z., Ji S., Sun H., Xiang D., Liu C., Hu Y., Wang X., Hui L. Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 2011, 475:386-389.
36. Yu B., He Z.Y., You P., Han Q.W., Xiang D., Chen F., Wang M.J., Liu C.C., Lin X.W., Borjigin U., et al. Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell 2013, 13:328-340.
37. Buganim Y., Itskovich E., Hu Y.C., Cheng A.W., Ganz K., Sarkar S., Fu D., Welstead G.G., Page D.C., Jaenisch R. Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors. Cell Stem Cell 2012, 11:373-386.
38. Efe J.A., Hilcove S., Kim J., Zhou H., Ouyang K., Wang G., Chen J., Ding S. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol 2011, 13:215-222.
39. Ieda M., Fu J.D., Delgado-Olguin P., Vedantham V., Hayashi Y., Bruneau B.G., Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010, 142:375-386.
40. Margariti A., Winkler B., Karamariti E., Zampetaki A., Tsai T.N., Baban D., Ragoussis J., Huang Y., Han J.D., Zeng L., et al. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels. Proc Natl Acad Sci U S A 2012, 109:13793-13798.
41. Nam Y.J., Song K., Luo X., Daniel E., Lambeth K., West K., Hill J.A., DiMaio J.M., Baker L.A., Bassel-Duby R., et al. Reprogramming of human fibroblasts toward a cardiac fate. Proc Natl Acad Sci U S A 2013, 110:5588-5593.
42. Hendry C.E., Vanslambrouck J.M., Ineson J., Suhaimi N., Takasato M., Rae F., Little M.H. Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. J Am Soc Nephrol 2013, 24:1424-1434.
43. Davies J.A., Unbekandt M., Ineson J., Lusis M., Little M.H. Dissociation of embryonic kidney followed by re-aggregation as a method for chimeric analysis. Methods Mol Biol 2012, 886:135-146.
44. Lusis M., Li J., Ineson J., Christensen M.E., Rice A., Little M.H. Isolation of clonogenic, long-term self renewing embryonic renal stem cells. Stem Cell Res 2010, 5:23-39.
45. Barak H., Huh S.H., Chen S., Jeanpierre C., Martinovic J., Parisot M., Bole-Feysot C., Nitschke P., Salomon R., Antignac C., et al. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell 2012, 22:1191-1207.
46. Brown A.C., Muthukrishnan S.D., Guay J.A., Adams D.C., Schafer D.A., Fetting J.L., Oxburgh L. Role for compartmentalization in nephron progenitor differentiation. Proc Natl Acad Sci U S A 2013, 110:4640-4645.
47. Karner C.M., Das A., Ma Z., Self M., Chen C., Lum L., Oliver G., Carroll T.J. Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 2011, 138:1247-1257.
48. Das A., Tanigawa S., Karner C.M., Xin M., Lum L., Chen C., Olson E.N., Perantoni A.O., Carroll T.J. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol 2013, 15:1035-1044.
49. Gao X., Chen X., Taglienti M., Rumballe B., Little M.H., Kreidberg J.A. Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development 2005, 132:5437-5449.
50. Little M.H., McMahon A.P. Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol 2012, 4.
51. Urbach A., Yermalovich A., Zhang J., Spina C.S., Zhu H., Perez-Atayde A.R., Shukrun R., Charlton J., Sebire N., Mifsud W., et al. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev 2014, 28:971-982.
52. Diep C.Q., Ma D., Deo R.C., Holm T.M., Naylor R.W., Arora N., Wingert R.A., Bollig F., Djordjevic G., Lichman B., et al. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 2011, 470:95-100.
53. Georgas K., Rumballe B., Valerius M.T., Chiu H.S., Thiagarajan R.D., Lesieur E., Aronow B.J., Brunskill E.W., Combes A.N., Tang D., et al. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol 2009, 332:273-286.
54. Harari-Steinberg O., Metsuyanim S., Omer D., Gnatek Y., Gershon R., Pri-Chen S., Ozdemir D.D., Lerenthal Y., Noiman T., Ben-Hur H., et al. Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease. EMBO Mol Med 2013, 5:1556-1568.
55. Metsuyanim S., Harari-Steinberg O., Buzhor E., Omer D., Pode-Shakked N., Ben-Hur H., Halperin R., Schneider D., Dekel B. Expression of stem cell markers in the human fetal kidney. PLoS ONE 2009, 4:e6709.
56. Brunskill E.W., Lai H.L., Jamison D.C., Potter S.S., Patterson L.T. Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production. BMC Dev Biol 2011, 11:15.
57. Angelotti M.L., Ronconi E., Ballerini L., Peired A., Mazzinghi B., Sagrinati C., Parente E., Gacci M., Carini M., Rotondi M., et al. Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. Stem Cells 2012, 30:1714-1725.
58. Kusaba T., Lalli M., Kramann R., Kobayashi A., Humphreys B.D. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci U S A 2014, 111:1527-1532.
59. Barker N., Rookmaaker M.B., Kujala P., Ng A., Leushacke M., Snippert H., van de Wetering M., Tan S., Van Es J.H., Huch M., et al. Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep 2012, 2:540-552.
60. Rinkevich Y., Montoro D.T., Contreras-Trujillo H., Harari-Steinberg O., Newman A.M., Tsai J.M., Lim X., Van-Amerongen R., Bowman A., Januszyk M., et al. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep 2014, 7:1270-1283.
61. Harding S.D., Armit C., Armstrong J., Brennan J., Cheng Y., Haggarty B., Houghton D., Lloyd-MacGilp S., Pi X., Roochun Y., et al. The GUDMAP database-an online resource for genitourinary research. Development 2011, 138:2845-2853.