Mammalian kidney development: Principles, progress, and projections

Cold Spring Harbor Perspectives in Biology

Volumn 4, Issue 5, 2012, Pages 3-

  Little, Melissa H ^a   McMahon, Andrew P ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

CELL COMMUNICATION; CELL LINEAGE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; KIDNEY; KIDNEY DISEASE; MORPHOGENESIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SIGNAL TRANSDUCTION;

CELL COMMUNICATION; CELL LINEAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; KIDNEY; KIDNEY DISEASES; MORPHOGENESIS; SIGNAL TRANSDUCTION;

EID: 84866166692     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a008300     Document Type: Article

References (158)

1. Abrahamson DR, Robert B. 2003. Derivation and differentiation of glomerular endothelial cells. Nephrol Dial Transplant 18: vi2-vi7.
2. Airik R, Bussen M, Singh MK, Petry M, Kispert A. 2006. Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest 116: 663-674.
3. Angers S, Moon RT. 2009. Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 10: 468-477.
4. Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, Elger M, Kriz W, Floege J, Moeller MJ. 2009. Recruitment of podocytes fromglomerular parietal epithelial cells. J Am Soc Nephrol 20: 333-343.
5. Ballermann BJ. 2005. Glomerular endothelial cell differentiation. Kidney Int 67: 1668-1671.
6. Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Costantini FD, Wilson PD, Mason IJ, Licht JD. 2006. Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. Dev Biol 299: 466-477.
7. Bates CM. 2011. Role of fibroblast growth factor receptor signaling in kidney development. Am J Physiol Renal Physiol 301: F245-F251.
8. Blomqvist SR, Vidarsson H, Fitzgerald S, Johansson BR, Ollerstam A, Brown R, Persson AE, Bergström G G, Enerbäck S. 2004. Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J Clin Invest 113: 1560-1570.
9. Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B. 2002. Nephric lineage specification by Pax2 and Pax8. Genes Dev 16: 2958-2970.
10. Boyle S, Shioda T, Perantoni AO, de Caestecker M. 2007. Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev Dyn 236: 2321-2330.
11. Boyle S, Misfeldt A, Chandler KJ, Deal KK, Southard-Smith EM, Mortlock DP, Baldwin HS, de Caestecker M. 2008. Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol 313: 234-245.
12. Brenner BM, Anderson S. 1992. The interrelationships among filtration surface area, blood pressure, and chronic renal disease. J Cardiovasc Pharmacol 19: S1-S7.
13. Brenner-Anantharam A, Cebrian C, Guillaume R, Hurtado R, Sun TT, Herzlinger D. 2007. Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 134: 1967-1975.
14. Bridgewater D, Rosenblum ND. 2009. Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis. Pediatr Nephrol 24: 1611-1619.
15. Brodbeck S, Englert C. 2004. Genetic determination of nephrogenesis: The Pax/Eya/Six gene network. Pediatr Nephrol 19: 249-255.
16. Brodbeck S, Besenbeck B, Englert C. 2004. The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter. Mech Dev 121: 1211-1222.
17. Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, et al. 2008. Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell 15: 781-791.
18. Brunskill EW, Lai HL, Jamison DC, Potter SS, Patterson LT. 2011. Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production. BMC Dev Biol 11: 15.
19. Burn SF, Webb A, Berry RL, Davies JA, Ferrer-Vaquer A, Hadjantonakis AK, Hastie ND, Hohenstein P. 2011. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol 352: 288-298.
20. Cai Y, Brophy PD, Levitan I, Stifani S, Dressler GR. 2003. Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation. EMBO J 22: 5522-5529.
21. Cain JE, Rosenblum ND. 2011. Control of mammalian kidney development by the Hedgehog signaling pathway. Pediatr Nephrol 26: 1365-1371.
22. Cain JE, Islam E, Haxho F, Chen L, Bridgewater D, Nieuwenhuis E, Hui CC, Rosenblum ND. 2009. GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One 4: e7313.
23. Caricasole A, Duarte A, Larsson SH, Hastie ND, Little M, Holmes G, Todorov I, Ward A. 1996. RNA binding by the Wilms tumor suppressor zinc finger proteins. Proc Natl Acad Sci 93: 7562-7566.
24. Carroll TJ, McMahon AP. 2003. Overview: The molecular basis of kidney development. In The kidney: From normal development to congenital disease (ed. Vize PD, et al.), pp. 343-376. Academic Press, London.
25. Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP. 2005. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 9: 283-292.
26. Caubit X, Lye CM, Martin E, Coré N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H, Woolf AS, et al. 2008. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 135: 3301-3310.
27. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R. 2007. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 134: 801-811.
28. Chi X, Hadjantonakis AK, Wu Z, Hyink D, Costantini F. 2009a. A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching. Genesis 47: 61-66.
29. Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, et al. 2009b. Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev Cell 17: 199-209.
30. Cohen T, Loutochin O, Amin M, Capolicchio JP, Goodyer P, Jednak R. 2007. PAX2 is reactivated in urinary tract obstruction and partially protects collecting duct cells fromprogrammed cell death. AmJ Physiol Renal Physiol 292: F1267-F1273.
31. Costantini F, Kopan R. 2010. Patterning a complex organ: Branching morphogenesis and nephron segmentation in kidney development. Dev Cell 18: 698-712.
32. Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, et al. 2011. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 470: 95-100.
33. Dressler GR. 2006. The cellular basis of kidney development. Annu Rev Cell Dev Biol 22: 509-529.
34. Dudley AT, Lyons KM, Robertson EJ. 1995. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9: 2795-2807.
35. Dudley AT, Godin RE, Robertson EJ. 1999. Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme. Genes Dev 13: 1601-1613.
36. Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber HP, Kikkawa Y, Miner JH, Quaggin SE. 2003. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 111: 707-716.
37. Eremina V, Baelde HJ, Quaggin SE. 2007. Role of the VEGF-A signaling pathway in the glomerulus: Evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol 106: p32-p37.
38. European Polycystic Kidney Disease Consortium. 1994. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. Cell 77: 881-894.
39. Faa G, Gerosa C, Fanni D, Nemolato S, Locci A, Cabras T, Martinelli V, Puddu M, Zaffanello M, Monga G, et al. 2010.Marked interindividual variability in renal maturation of preterm infants: Lessons fromautopsy. J Matern-Fetal Neo M 23: 129-133.
40. Gao X, Chen X, Taglienti M, Rumballe B, Little MH, Kreidberg JA. 2005. Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development 132: 5437-5449.
41. Georgas KM, Rumballe BA, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, et al. 2009. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol 332: 273-286.
42. Gong KQ, Yallowitz AR, Sun H, Dressler GR, Wellik DM. 2007. A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol 27: 7661-7668.
43. Grieshammer U, Le Ma, Plump AS, Wang F, Tessier-Lavigne M, Martin GR. 2004. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell 6: 709-717.
44. Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR. 2005. FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development 132: 3847-3857.
45. Grote D, Souabni A, Busslinger M, Bouchard M. 2006. Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133: 53-61.
46. Gruenwald P, Popper H. 1940. The histogenesis and physiology of the renal glomerulus in early postnatal life. J Urol 43: 452-466.
47. Guay-Woodford LM. 2003. Murine models of polycystic kidney disease: Molecular and therapeutic insights. Am J Physiol Renal Physiol 285: F1034-F1049.
48. Hall JG, Pallister PD, Clarren SK, Beckwith JB, Wiglesworth FW, Fraser FC, Cho S, Benke PJ, Reed SD. 1980. Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus and postaxial polydactyly-A new syndrome? Part I: Clinical, causal, and pathogenetic considerations. Am J Med Genet 7: 47-74.
49. Harding SD, Armit C, Armstrong J, Brennan J, Cheng Y, Haggarty B, Houghton D, Lloyd-Macgilp S, Pi X, Roochun Y, et al. 2011. The GUDMAP database-An online resource for genitourinary research. Development 138: 2845-2853.
50. Harris PC, Torres VE. 2009. Polycystic kidney disease. Annu Rev Med 60: 321-337.
51. Hartman HA, Lai HL, Patterson LT. 2007. Cessation of renal morphogenesis in mice. Dev Biol 310: 379-387.
52. Harvey SJ, Jarad G, Cunningham J, Goldberg S, Schermer B, Harfe BD, McManus MT, Benzing T, Miner JH. 2008. Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol 19: 2150-2158.
53. Hatini V, Huh SO, Herzlinger D, Soares VC, Lai E. 1996. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev 10: 1467-1478.
54. Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D. 1991. Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest 64: 777-784.
55. Ho J, Ng KH, Rosen S, Dostal A, Gregory RI, Kreidberg JA. 2008. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol 19: 2069-2075.
56. Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND. 2006. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-578.
57. Hughson M, Farris AB III, Douglas-Denton R, Hoy WE, Bertram JF. 2003. Glomerular number and size in autopsy kidneys: The relationship to birth weight. Kidney Int 63: 2113-2122.
58. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV. 2008. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2: 284-291.
59. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS. 2010. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176: 85-97.
60. Humphreys BD, Czerniak S, Dirocco DP, Hasnain W, Cheema R, Bonventre JV. 2011. Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci 108: 9226-9231.
61. Hurd TW, Hildebrandt F. 2011. Mechanisms of nephronophthisis and related ciliopathies. Nephron Exp Nephrol 118: e9-e14.
62. Hyink DP, Tucker DC, St John PL, Leardkamolkarn V, Accavitti MA, Abrass CK, Abrahamson DR. 1996. Endogenous origin of glomerular endothelial and mesangial cells in grafts of embryonic kidneys. Am J Physiol 270: F886-F899.
63. Ishibe S, Karihaloo A, Ma H, Zhang J, Marlier A, Mitobe M, Togawa A, Schmitt R, Czyczk J, Kashgarian M, et al. 2009.Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 136: 337-345.
64. Jain S. 2009. The many faces of RET dysfunction in kidney. Organogenesis 5: 95-108.
65. Jain S, Encinas M, Johnson EMJr, Milbrandt J. 2006. Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev 20: 321-333.
66. Jain S, Knoten A, Hoshi M, Wang H, Vohra B, Heuckeroth RO, Milbrandt J. 2010. Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest 120: 778-790.
67. James RG, Kamei CN, Wang Q, Jiang R, Schultheiss TM. 2006. Oddskipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development 133: 2995-3004.
68. Jeong HW, Jeon US, Koo BK, Kim WY, Im SK, Shin J, Cho Y, Kim J, Kong YY. 2009. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest 119: 3290-3300.
69. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ. 2009. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 41: 793-799.
70. Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ. 2011. Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 138: 1247-1257.
71. Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S. 2004. Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder. Nat Genet 36: 999-1002.
72. Kobayashi A, Kwan KM, Carroll TJ, McMahon AP, Mendelsohn CL, Behringer RR. 2005. Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development 132: 2809-2823.
73. Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP. 2008. Six2 defines and regulates a multipotent selfrenewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3: 169-181.
74. Kopan R, Cheng HT, Surendran K. 2007. Molecular insights into segmentation along the proximal-distal axis of the nephron. J Am Soc Nephrol 18: 2014-2020.
75. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R. 1993. WT-1 is required for early kidney development. Cell 74: 679-691.
76. Kume T, Deng K, Hogan BL. 2000.Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development 127: 1387-1395.
77. Kuure S, Cebrian C, Machingo Q, Lu BC, Chi X, Hyink D, D'Agati V, Gurniak C, Witke W, Costantini F. 2010. Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis. PLoS Genet 6: e1001176.
78. Larsson SH, Charlieu JP, Miyagawa K, Engelkamp D, Rassoulzadegan M, Ross A, Cuzin F, van Heyningen V, Hastie ND. 1995. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell 81: 391-401.
79. Li J, Deane JA, Campanale NV, Bertram JF, Ricardo SD. 2007. The contribution of bone marrow-derived cells to the development of renal interstitial fibrosis. Stem Cells 25: 697-706.
80. Li J, Qu X, Bertram JF. 2009. Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. AmJ Pathol 175: 1380-1388.
81. Lim KC, Lakshmanan G, Crawford SE, Gu Y, Grosveld F, Engel JD. 2000. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet 25: 209-212.
82. Lindahl P, Hellstrom M, Kalen M, Karlsson L, Pekny M, Pekna M, Soriano P, Betsholtz C. 1998. Paracrine PDGF-B/PDGF-Rβ signaling controls mesangial cell development in kidney glomeruli. Development 125: 3313-3322.
83. Little M, Wells C. 1997. A clinical overview of WT1 gene mutations. Hum Mutat 9: 209-225.
84. Little MH, Prosser J, Condie A, Smith PJ, Van Heyningen V, Hastie ND. 1992. Zinc finger point mutations within the WT1 gene inWilms tumor patients. Proc Natl Acad Sci 89: 4791-4795.
85. Little M, Holmes G, Walsh P. 1999. WT1: What has the last decade told us? Bioessays 21: 191-202.
86. Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, MacNeil L, Hoshi M, et al. 2009. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet 41: 1295-1302.
87. Lusis M, Li J, Ineson J, Li J, Little MH. 2010. Isolation and culture of metanephric mesenchyme-derived nephrospheres reinforces evidence that embryonic renal progenitors are multipotent and exhaust during cessation of nephron formation. Stem Cell Res 5: 23-39.
88. Mah SP, Saueressig H, Goulding M, Kintner C, Dressler GR. 2000. Kidney development in cadherin-6 mutants: Delayed mesenchyme-to-epithelial conversion and loss of nephrons. Dev Biol 223: 38-53.
89. Manie S, Santoro M, Fusco A, Billaud M. 2001. The RETreceptor: Function in development and dysfunction in congenital malformation. Trends Genet 17: 580-589.
90. Marlier A, Schmidt-Ott KM, Gallagher AR, Barasch J, Karihaloo A. 2009. VEGF as an epithelial cell morphogen modulates branching moprhogenesis of embryonic kidney by directly acting on the ureteric bud. Mech Dev 126: 91-98.
91. Marose TD, Merkel CE, McMahon AP, Carroll TJ. 2008. β-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol 314: 112-126.
92. Martínez-Estrada OM, Lettice LA, Essafi A, Guadix JA, Slight J, Velecela V, Hall E, Reichmann J, Devenney PS, Hohenstein P, et al. 2010.Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat Genet 42: 89-93.
93. McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, et al. 2008. GUDMAP: The genitourinary developmental molecular anatomy project. J Am Soc Nephrol 19: 667-671.
94. Metzger RJ, Klein OD, Martin GR, Krasnow MA. 2008. The branching programme of mouse lung development. Nature 453: 745-750.
95. Michos O, Gonçalves A, Lopez-Rios J, Tiecke E, Naillat F, Beier K, Galli A, Vainio S, Zeller R. 2007. Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development 134: 2397-2405.
96. Michos O, Cebrian C, Hyink D, Grieshammer U, Williams L, D'Agati V, Licht JD, Martin GR, Costantini F. 2010. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. PLoS Genet 6: e1000809.
97. Miner JH. 2005. Building the glomerulus: A matricentric view. J Am Soc Nephrol 16: 857-861.
98. Miyazaki Y, Oshima K, Fogo A, Ichikawa I. 2003. Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int 63: 835-844.
99. Mudumana SP, Hentschel D, Liu Y, Vasilyev A, Drummond IA. 2008. Odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development 135: 3355-3367.
100. Mugford JW, Sipila P, McMahon JA, McMahon AP. 2008a. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenigor compartment within the mammalian kidney. Dev Biol 324: 88-98.
101. Mugford JW, Sipila P, Kobayashi A, Behringer RR, McMahon AP. 2008b. Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol 319: 396-405.
102. Mugford JW, Yu J, Kobayashi A, McMahon AP. 2009. High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol 333: 312-323.
103. Müller RU, Zank S, Fabretti F, Benzing T. 2011. Caenorhabditis elegans, a model organism for kidney research: From cilia to mechanosensation and longevity. Curr Opin Nephrol Hypertens 20: 400-408.
104. Nakai S, Sugitani Y, Sato H, Ito S, Miura Y, Ogawa M, Nishi M, Jishage K, Minowa O, Noda T. 2003. Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development 130: 4751-4759.
105. Nakano T, Niimura F, Hohenfellner K, Miyakita E, Ichikawa I. 2003. Screening for mutations in BMP4 and FOXC1 genes in congenital anomalies of the kidney and urinary tract in humans. Tokai J Exp Clin Med 28: 121-126.
106. Oxburgh L, Chu GC, Michael SK, Robertson EJ. 2004. TGFb superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131: 4593-4605.
107. Oxburgh L, Brown AC, Fetting J, Hill B. 2011. BMPsignaling in the nephron progenitor niche. Pediatr Nephrol 26: 1491-1497.
108. Pallister PD, Hecht F, Herrman J. 1989. Three additional cases of the congenital hypothalamic "hamartoblastoma" (Pallister-Hall) syndrome. Am J Med Genet 33: 500-501.
109. Park JS, Valerius MT, McMahon AP. 2007. Wnt/b-catenin signaling regulates nephron induction during mouse kidney development. Development 134: 2533-2539.
110. Patel SR, Kim D, Levitan I, Dressler GR. 2007. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell 13: 580-592.
111. Pedersen A, Skjong C, Shawlot W. 2005. Lim 1 is required for nephric duct extension and ureteric bud morphogenesis. Dev Biol 288: 571-581.
112. Pepicelli CV, Kispert A, Rowitch DH, McMahon AP. 1997.GDNF induces branching and increased cell proliferation in the ureter of the mouse. Dev Biol 192: 193-198.
113. Perälä N, Jakobson M, Ola R, Fazzari P, Penachioni JY, Nymark M, Tanninen T, Immonen T, Tamagnone L, Sariola H. 2011. Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation 81: 81-91.
114. Perantoni AO, Timofeeva O, Naillat F, Richman C, Pajni-Underwood S, Wilson C, Vainio S, Dove LF, Lewandoski M. 2005. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development 132: 3859-3871.
115. Pini Prato A, Musso M, Ceccherini I, Mattioli G, Giunta C, Ghiggeri GM, Jasonni V. 2009. Hirschsprung disease and congenital anomalies of the kidney and urinary tract (CAKUT): A novel syndromic association. Medicine 88: 83-90.
116. Poladia DP, Kish K, Kutay B, Hains D, Kegg H, Zhao H, Bates CM. 2006. Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol 291: 325-339.
117. Quaggin SE, Kreidberg JA. 2008. Development of the renal glomerulus: Good neighbors and good fences. Development 135: 609-620.
118. Raatikainen-Ahokas A, Hytönen M, Tenhunen A, Sainio K, Sariola H. 2000. BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev Dyn 217: 146-158.
119. Reginensi A, Clarkson M, Neirijnck Y, Lu B, Ohyama T, Groves AK, Sock E, Wegner M, Costantini F, Chaboissier MC, et al. 2011. SOX9 controls epithelial branching by activating RETeffector genes during kidney development. Hum Mol Genet 20: 1143-1153.
120. Robert B, St John PL, Abrahamson DR. 1998. Direct visualization of renal vascular morphogenesis in Flk1 heterozygous mutant mice. Am J Physiol 275: F164-F172.
121. Ronconi E, Sagrinati C, Angelotti ML, Lazzeri E, Mazzinghi B, Ballerini L, Parente E, Becherucci F, Gacci M, Carini M, et al. 2009. Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol 20: 322-332.
122. Rosselot C, Spraggon L, Chia I, Batourina E, Riccio P, Lu B, Niederreither K, Dolle P, Duester G, Chambon P, et al. 2010. Non-cell-autonomous retinoid signaling is crucial for renal development. Development 137: 283-292.
123. Rumballe B, Georgas KM, Combes AN, Ju AL, Gilbert T, Little MH. 2011. Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. Dev Biol doi: 10.1016/j.ydbio.2011.09.011.
124. Sajithlal G, Zou D, Silvius D, Xu PX. 2005. Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol 284: 323-336.
125. Sato A, Matsumoto Y, Koide U, Kataoka Y, Yoshida N, Yokota T, Asashima M, Nishinakamura R. 2003. Zinc finger protein sall2 is not essential for embryonic and kidney development. Mol Cell Biol 23: 62-69.
126. Saxén L. 1987. Organogenesis of the kidney. Cambridge University Press, Cambridge.
127. Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G. 2006. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J 25: 5214-5228.
128. Seow HF, Bröer S, Bröer A, Bailey CG, Potter SJ, Cavanaugh JA, Rasko JE. 2004. Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet 36: 1003-1007.
129. Shi S, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, et al. 2008. Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. JAmSocNephrol 19: 2159-2169.
130. Sim EU, Smith A, Szilagi E, Rae F, Ioannou P, Lindsay MH, Little MH. 2002. Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1. Oncogene 21: 2948-2960.
131. Simons M, Hartleben B, Huber TB. 2009. Podocyte polarity signalling. Curr Opin Nephrol Hypertens 18: 324-330.
132. Song R, Yosypiv IV. 2011. Genetics of congenital anomalies of the kidney and urinary tract. Pediatr Nephrol 26: 353-364.
133. Song R, Spera M, Garrett C, Yosypiv IV. 2010. Angiotensin II-induced activation of c-Ret signaling is critical in ureteric bud branching morphogenesis. Mech Dev 127: 21-27.
134. Tabatabaeifar M, Schlingmann KP, Litwin M, Emre S, Bakkaloglu A, Mehls O, Antignac C, Schaefer F, Weber S, ESCAPE Trial Group. 2009. Functional analysis of BMP4 mutations identified in pediatric CAKUT patients. Pediatr Nephrol 24: 2361-2368.
135. Takeda S, Rogers SA, Hammerman MR. 2006. Differential origin for endothelial and mesangial cells after transplantation of pig fetal renal primordia into rats. Transpl Immunol 15: 211-215.
136. Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, et al. 2006. Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J 25: 1160-1174.
137. Tanigawa S, Wang H, Yang Y, Sharma N, Tarasova N, Ajima R, Yamaguchi TP, Rodriguez LG, Perantoni AO. 2011. Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism. Dev Biol 352: 58-69.
138. Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH. 2011. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One 6: e17286.
139. Torres M, Gomez-Pardo E, Dressler GR, Gruss P. 1995. Pax-2 controls multiple steps of urogenital development. Development 121: 4057-4065.
140. Tsang TE, Shawlot W, Kinder SJ, Kobayashi A, Kwan KM, Schughart K, Kania A, Jessell TM, Behringer RR, Tam PP. 2000. Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo. Dev Biol 223: 77-90.
141. Tufro A, Teichman J, Banu N, Villegas G. 2007. Crosstalk between VEGF-A/VEGFR2 and GDNF/RETsignaling pathways. Biochem Biophys Res Commun 358: 410-416.
142. Tufro A, Teichman J, Woda C, Villegas G. 2008. Semaphorin3a inhibits ureteric bud branching morphogenesis. Mech Dev 125: 558-568.
143. Ueda H, Miyazaki Y, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I. 2008. Bmp in podocytes is essential for normal glomerular capillary formation. J Am Soc Nephrol 19: 685-694.
144. Vajjhala PR, Macmillan E, Gonda T, Little M. 2003. The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling. FEBS Lett 554: 143-148.
145. Vanslambrouck JM, Bröer A, Thavyogarajah T, Holst J, Bailey CG, Bröer S, Rasko JE. 2010. Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria. Biochem J 428: 397-407.
146. Villanueva S, Céspedes C, Vio CP. 2006. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am J Physiol Regul Integr Comp Physiol 290: R861-R870.
147. Vogetseder A, Palan T, Bacic D, Kaissling B, Le Hir M. 2007. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. Am J Physiol Cell Physiol 294: C22-C28.
148. Wellik DM, Hawkes PJ, Capecchi MR. 2002. Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev 16: 1423-1432.
149. Wells J, Rivera MN, Kim WJ, Starbuck K, Haber DA. 2010. The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes. Mol Cancer Res 8: 975-985.
150. Winyard P, Chitty LS. 2008. Dysplastic kidneys. Semin FetalNeonatalMed 13: 142-151.
151. Wong A, Bogni S, Kokta P, de Graaff E, D'Agati V, Costantini F, Pachnis V. 2005. Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosone kinase isoform. Mol Cell Biol 25: 9661-9673.
152. Xu PX, Zheng W, Huang L, Maire P, Laclef C, Silvius D. 2003. Six1 is required for the early organogenesis of mammalian kidney. Development 130: 3085-3094.
153. Ye X, Wang Y, Rattner A, Nathans J. 2011. Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney. Development 138: 1161-1172.
154. Yosypiv IV, Schroeder M, El-Dahr SS. 2006. Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis. J Am Soc Nephrol 17: 1005-1014.
155. Yu J, Carroll TJ, McMahon AP. 2002. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129: 5301-5312.
156. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP. 2009. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136: 161-171.
157. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. 2008. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 19: 2282-2287.
158. Zhdanova O, Srivastava S, Di L, Li Z, Tchelebi L, Dworkin S, Johnstone DB, Zavadil J, Chong MM, Littman DR, et al. 2011. The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int 80: 719-730.