Effect of the Conjugation Density of Triphenylphosphonium Cation on the Mitochondrial Targeting of Poly(amidoamine) Dendrimers

Molecular Pharmaceutics

Volumn 12, Issue 8, 2015, Pages 3043-3053

  Bielski, Elizabeth R ^a   Zhong, Qian ^a   Brown, Matthew ^a   Da Rocha, Sandro R P ^a  

^a Wayne State University   (United States)

Author keywords

drug delivery; mitochondrial targeting; PAMAM dendrimers; PEG; polyethylene glycol; TPP; triphenylphosphonium cation

Indexed keywords

ANTINEOPLASTIC AGENT; CATION; DENDRIMER; MACROGOL; NANOCARRIER; PHOSPHONIUM DERIVATIVE; POLYAMIDOAMINE; TRIPHENYLPHOSPHONIUM CATION; UNCLASSIFIED DRUG; DRUG CARRIER; MACROGOL DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; POLYAMINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL DENSITY; CLINICAL ASSESSMENT; CLINICAL EFFECTIVENESS; CONFOCAL MICROSCOPY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG SYNTHESIS; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; LUNG ALVEOLUS CELL CARCINOMA; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TARGETING SIGNAL; OUTCOME ASSESSMENT; PRIORITY JOURNAL; APOPTOSIS; CHEMISTRY; DRUG EFFECTS; LUNG NEOPLASMS; MITOCHONDRION; PATHOLOGY; TUMOR CELL CULTURE;

APOPTOSIS; DENDRIMERS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; ORGANOPHOSPHORUS COMPOUNDS; POLYAMINES; POLYETHYLENE GLYCOLS; TUMOR CELLS, CULTURED;

EID: 84938541559     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00320     Document Type: Article

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