-
1
-
-
0036194529
-
Mitochondria as a pharmacological target
-
DOI 10.1124/pr.54.1.101
-
Szewczyk, A. & Wojtczak, L. Mitochondria as a pharmacological target. Pharmacol. Rev. 54, 101-127 (2002). (Pubitemid 34211027)
-
(2002)
Pharmacological Reviews
, vol.54
, Issue.1
, pp. 101-127
-
-
Szewczyk, A.1
Wojtczak, L.2
-
2
-
-
71549171732
-
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism
-
Pathania, D., Millard, M. & Neamati, N. Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism. Adv. Drug Deliv. Rev. 61, 1250-1275 (2009).
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 1250-1275
-
-
Pathania, D.1
Millard, M.2
Neamati, N.3
-
3
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
DOI 10.1126/science.1099320
-
Green, D. R. & Kroemer, G. The pathophysiology of mitochondrial cell death. Science 305, 626-629 (2004). (Pubitemid 39006738)
-
(2004)
Science
, vol.305
, Issue.5684
, pp. 626-629
-
-
Green, D.R.1
Kroemer, G.2
-
4
-
-
84871604292
-
Targeting cancer cell mitochondria as a therapeutic approach
-
Wen, S., Zhu, D. & Huang, P. Targeting cancer cell mitochondria as a therapeutic approach. Future Med. Chem. 5, 53-67 (2013).
-
(2013)
Future Med. Chem.
, vol.5
, pp. 53-67
-
-
Wen, S.1
Zhu, D.2
Huang, P.3
-
5
-
-
78149359547
-
Mitochondrially targeted anticancer agents
-
Biasutto, L., Dong, L. F., Zoratti, M. & Neuzil, J. Mitochondrially targeted anticancer agents. Mitochondrion 10, 670-681 (2010).
-
(2010)
Mitochondrion
, vol.10
, pp. 670-681
-
-
Biasutto, L.1
Dong, L.F.2
Zoratti, M.3
Neuzil, J.4
-
6
-
-
84880907153
-
A new anti-cancer strategy of damaging mitochondria by proapoptotic peptide functionalized gold nanoparticles
-
Chen, W. H. et al. A new anti-cancer strategy of damaging mitochondria by proapoptotic peptide functionalized gold nanoparticles. Chem. Commun. 49, 6403-6405 (2013).
-
(2013)
Chem. Commun.
, vol.49
, pp. 6403-6405
-
-
Chen, W.H.1
-
7
-
-
33847618832
-
Mitochondrial drug delivery and mitochondrial disease therapy - An approach to liposome-based delivery targeted to mitochondria
-
DOI 10.1016/j.mito.2006.12.003, PII S1567724906002443, Mitochondria and Life
-
Yamada, Y., Akita, H., Kogure, K., Kamiya, H. & Harashima, H. Mitochondrial drug delivery and mitochondrial disease therapy-an approach to liposomebased delivery targeted to mitochondria. Mitochondrion 7, 63-71 (2007). (Pubitemid 46351977)
-
(2007)
Mitochondrion
, vol.7
, Issue.1-2
, pp. 63-71
-
-
Yamada, Y.1
Akita, H.2
Kogure, K.3
Kamiya, H.4
Harashima, H.5
-
8
-
-
0034608786
-
Mitochondrion as a novel target of anticancer chemotherapy
-
Costantini, P., Jacotot, E., Decaudin, D. & Kroemer, G. Mitochondrion as a novel target of anticancer chemotherapy. J. Natl. Cancer Inst. 92, 1042-1053 (2000). (Pubitemid 30616479)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.13
, pp. 1042-1053
-
-
Costantini, P.1
Jacotot, E.2
Decaudin, D.3
Kroemer, G.4
-
9
-
-
26444489119
-
Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis
-
DOI 10.1126/science.1117105
-
Spierings, D. et al. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science 310, 66-67 (2005). (Pubitemid 41434533)
-
(2005)
Science
, vol.310
, Issue.5745
, pp. 66-67
-
-
Spierings, D.1
McStay, G.2
Saleh, M.3
Bender, C.4
Chipuk, J.5
Maurer, U.6
Green, D.R.7
-
10
-
-
0032819838
-
Anti-cancer activity of targeted pro-apoptotic peptides
-
DOI 10.1038/12469
-
Ellerby, H. M. et al. Anti-cancer activity of targeted pro-apoptotic peptides. Nat. Med. 5, 1032-1038 (1999). (Pubitemid 29439574)
-
(1999)
Nature Medicine
, vol.5
, Issue.9
, pp. 1032-1038
-
-
Ellerby, H.M.1
Arap, W.2
Ellerby, L.M.3
Kain, R.4
Andrusiak, R.5
Del Rio, G.6
Krajewski, S.7
Lombardo, C.R.8
Rao, R.9
Ruoslahti, E.10
Bredesen, D.E.11
Pasqualini, R.12
-
11
-
-
80054795004
-
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma
-
Agemy, L. et al. Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc. Natl. Acad. Sci. U. S. A. 108, 17450-17455 (2011).
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 17450-17455
-
-
Agemy, L.1
-
12
-
-
78650875977
-
Receptor mediated tumor targeting: An emerging approach for cancer therapy
-
Mohanty, C., Das, M., Kanwar, J. R. & Sahoo, S. K. Receptor mediated tumor targeting: an emerging approach for cancer therapy. Curr. Drug Deliv. 8, 45-58 (2011).
-
(2011)
Curr. Drug Deliv.
, vol.8
, pp. 45-58
-
-
Mohanty, C.1
Das, M.2
Kanwar, J.R.3
Sahoo, S.K.4
-
13
-
-
84865422031
-
Photocontrolled targeted drug delivery: Photocaged biologically active folic acid as a light-responsive tumortargeting molecule
-
Fan, N. C., Cheng, F. Y., Ho, J. A. & Yeh, C. S. Photocontrolled targeted drug delivery: photocaged biologically active folic acid as a light-responsive tumortargeting molecule. Angew. Chem. Int. Ed. 51, 8806-8810 (2012).
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 8806-8810
-
-
Fan, N.C.1
Cheng, F.Y.2
Ho, J.A.3
Yeh, C.S.4
-
14
-
-
74049133619
-
Subcellular targeting strategies for drug design and delivery
-
Rajendran, L., Knölker, H. J. & Simons, K. Subcellular targeting strategies for drug design and delivery. Nat. Rev. Drug Discov. 9, 29-42 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 29-42
-
-
Rajendran, L.1
Knölker, H.J.2
Simons, K.3
-
15
-
-
34447298630
-
Targeted charge-reversal nanoparticles for nuclear drug delivery
-
DOI 10.1002/anie.200605254
-
Xu, P., Van Kirk, E. A., Zhan, Y., Murdoch, W. J., Radosz, M. & Shen, Y. Targeted charge-reversal nanoparticles for nuclear drug delivery. Angew. Chem. Int. Ed. 46, 4999-5002 (2007). (Pubitemid 47055979)
-
(2007)
Angewandte Chemie - International Edition
, vol.46
, Issue.26
, pp. 4999-5002
-
-
Xu, P.1
Van Kirk, E.A.2
Zhan, Y.3
Murdoch, W.J.4
Radosz, M.5
Shen, Y.6
-
16
-
-
84859343412
-
Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles
-
Pan, L., He, Q., Liu, J., Chen, Y.,Ma, M., Zhang, L. & Shi, J. Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles. J. Am. Chem. Soc. 134, 5722-5725 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 5722-5725
-
-
Pan, L.1
He, Q.2
Liu, J.3
Chen, Y.4
Ma, M.5
Zhang, L.6
Shi, J.7
-
17
-
-
38949215454
-
Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases
-
Low, P. S., Henne, W. A. & Doorneweerd, D. D. Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc. Chem. Res. 41, 120-129 (2008).
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 120-129
-
-
Low, P.S.1
Henne, W.A.2
Doorneweerd, D.D.3
-
18
-
-
0037965634
-
Delivery of bioactive molecules to mitochondria in vivo
-
DOI 10.1073/pnas.0931245100
-
Smith, R. A., Porteous, C. M., Gane, A. M. & Murphy, M. P. Delivery of bioactive molecules to mitochondria in vivo. Proc. Natl. Acad. Sci. U. S. A. 100, 5407-5412 (2003). (Pubitemid 36542718)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.9
, pp. 5407-5412
-
-
Smith, R.A.J.1
Porteous, C.M.2
Gane, A.M.3
Murphy, M.P.4
-
19
-
-
33750063955
-
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
-
DOI 10.1073/pnas.0601945103
-
Robinson, K. M. et al. Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc. Natl. Acad. Sci. U. S. A. 103, 15038-15043 (2006). (Pubitemid 44583160)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.41
, pp. 15038-15043
-
-
Robinson, K.M.1
Janes, M.S.2
Pehar, M.3
Monette, J.S.4
Ross, M.F.5
Hagen, T.M.6
Murphy, M.P.7
Beckman, J.S.8
-
20
-
-
0025001650
-
All-D-magainin: Chirality, antimicrobial activity and proteolytic resistance
-
DOI 10.1016/0014-5793(90)81351-N
-
Bessalle, R., Kapitkovsky, A., Gorea, A., Shalit, I. & Fridkin, M. All-D-magainin: chirality, antimicrobial activity and proteolytic resistance. FEBS Lett. 274, 151-155 (1990). (Pubitemid 20378143)
-
(1990)
FEBS Letters
, vol.274
, Issue.1-2
, pp. 151-155
-
-
Bessalle, R.1
Kapitkovsky, A.2
Gorea, A.3
Shalit, I.4
Fridkin, M.5
-
21
-
-
0029761653
-
De novo antimicrobial peptides with low mammalian cell toxicity
-
DOI 10.1021/jm9509410
-
Javadpour, M. M. et al. De novo antimicrobial peptides with low mammalian cell toxicity. J. Med. Chem. 39, 3107-3113 (1996). (Pubitemid 26260315)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.16
, pp. 3107-3113
-
-
Javadpour, M.M.1
Juban, M.M.2
Lo, W.-C.J.3
Bishop, S.M.4
Alberty, J.B.5
Cowell, S.M.6
Becker, C.L.7
McLaughlin, M.L.8
-
22
-
-
84868560034
-
The first generation of b-galactosidase-responsive prodrugs designed for the selective treatment of solid tumors in prodrug monotherapy
-
Legigan, T. et al. The first generation of b-galactosidase-responsive prodrugs designed for the selective treatment of solid tumors in prodrug monotherapy. Angew. Chem. Int. Ed. 51, 11606-11610 (2012).
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 11606-11610
-
-
Legigan, T.1
-
23
-
-
40449112930
-
Large-scale chemical dissection of mitochondrial function
-
DOI 10.1038/nbt1387, PII NBT1387
-
Wagner, B. K. et al. Large-scale chemical dissection of mitochondrial function. Nat. Biotechnol. 26, 343-351 (2008). (Pubitemid 351355127)
-
(2008)
Nature Biotechnology
, vol.26
, Issue.3
, pp. 343-351
-
-
Wagner, B.K.1
Kitami, T.2
Gilbert, T.J.3
Peck, D.4
Ramanathan, A.5
Schreiber, S.L.6
Golub, T.R.7
Mootha, V.K.8
-
24
-
-
0025806764
-
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
-
Smiley, S. T. et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc. Natl. Acad. Sci. U. S. A. 88, 3671-3675 (1991). (Pubitemid 21916685)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.9
, pp. 3671-3675
-
-
Smiley, S.T.1
Reers, M.2
Mottola-Hartshorn, C.3
Lin, M.4
Chen, A.5
Smith, T.W.6
Steele Jr., G.D.7
Chen, L.B.8
-
25
-
-
79951571474
-
Mitochondrial membrane potential probes and the proton gradient: A practical usage guide
-
Perry, S. W., Norman, J. P., Barbieri, J., Brown, E. B. & Gelbard, H. A. Mitochondrial membrane potential probes and the proton gradient: a practical usage guide. Biotechniques 50, 98-115 (2011).
-
(2011)
Biotechniques
, vol.50
, pp. 98-115
-
-
Perry, S.W.1
Norman, J.P.2
Barbieri, J.3
Brown, E.B.4
Gelbard, H.A.5
-
26
-
-
0032575752
-
Mitochondria and apoptosis
-
Green, D. R. & Reed, J. C. Mitochondria and apoptosis. Science 281, 1309-1312 (1998). (Pubitemid 28406816)
-
(1998)
Science
, vol.281
, Issue.5381
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
27
-
-
0037005891
-
A study on permeability transition pore opening and cytochrome c release from mitochondria, induced by caspase-3 in vitro
-
DOI 10.1016/S0014-5793(01)03228-8, PII S0014579301032288
-
Xia, T., Jiang, C., Li, L., Wu, C., Chen, Q. & Liu, S. S. A study on permeability transition pore opening and cytochrome c release from mitochondria, induced by caspase-3 in vitro. FEBS Lett. 510, 62-66 (2002). (Pubitemid 34084885)
-
(2002)
FEBS Letters
, vol.510
, Issue.1-2
, pp. 62-66
-
-
Xia, T.1
Jiang, C.2
Li, L.3
Wu, C.4
Chen, Q.5
Liu, S.-S.6
-
28
-
-
32444434664
-
Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis
-
DOI 10.1126/science.1115035
-
Lakhani, S. A. et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311, 847-851 (2006). (Pubitemid 43228848)
-
(2006)
Science
, vol.311
, Issue.5762
, pp. 847-851
-
-
Lakhani, S.A.1
Masud, A.2
Kuida, K.3
Porter Jr., G.A.4
Booth, C.J.5
Mehal, W.Z.6
Inayat, I.7
Flavell, R.A.8
-
29
-
-
33845977959
-
Mitochondrial membrane permeabilization in cell death
-
DOI 10.1152/physrev.00013.2006
-
Kroemer, G., Galluzzi, L. & Brenner, C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87, 99-163 (2007). (Pubitemid 46209992)
-
(2007)
Physiological Reviews
, vol.87
, Issue.1
, pp. 99-163
-
-
Kroemer, G.1
Galluzzi, L.2
Brenner, C.3
-
30
-
-
25144506835
-
Autophagy in cell death: An innocent convict?
-
DOI 10.1172/JCI26390
-
Levine, B. & Yuan, J. Autophagy in cell death: an innocent convict? J. Clin. Invest. 115, 2679-2688 (2005). (Pubitemid 41434392)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2679-2688
-
-
Levine, B.1
Yuan, J.2
-
31
-
-
56749170677
-
Autophagic cell death: The story of amisnomer
-
Kroemer, G.&Levine, B. Autophagic cell death: the story of amisnomer. Nat. Rev. Mol. Cell Biol. 9, 1004-1010 (2008).
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 1004-1010
-
-
Kroemer, G.1
Levine, B.2
-
32
-
-
34249934085
-
Selective degradation of mitochondria by mitophagy
-
DOI 10.1016/j.abb.2007.03.034, PII S0003986107001622, Highlight Issue: Pro- and antiapoptotic Signalling
-
Kim, I., Rodriguez-Enriquez, S. & Lemasters, J. J. Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 462, 245-253 (2007). (Pubitemid 46876640)
-
(2007)
Archives of Biochemistry and Biophysics
, vol.462
, Issue.2
, pp. 245-253
-
-
Kim, I.1
Rodriguez-Enriquez, S.2
Lemasters, J.J.3
-
33
-
-
0036479052
-
Mitochondrial disappearance from cells: A clue to the role of autophagy in programmed cell death and disease?
-
Tolkovsky, A. M., Xue, L., Fletcher, G. C. & Borutaite, V. Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease? Biochimie 84, 233-240 (2002).
-
(2002)
Biochimie
, vol.84
, pp. 233-240
-
-
Tolkovsky, A.M.1
Xue, L.2
Fletcher, G.C.3
Borutaite, V.4
-
34
-
-
84870597632
-
Programmed cell death: Molecular mechanisms and implications for safety assessment of nanomaterials
-
Andón, F. T. & Fadeel, B. Programmed cell death: molecular mechanisms and implications for safety assessment of nanomaterials. Acc. Chem. Res. 46, 733-742 (2013).
-
(2013)
Acc. Chem. Res.
, vol.46
, pp. 733-742
-
-
Andón, F.T.1
Fadeel, B.2
-
35
-
-
11144221007
-
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
-
DOI 10.1073/pnas.0408345102
-
Shao, Y., Gao, Z., Marks, P. A. & Jiang, X. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc. Natl. Acad. Sci. U. S. A. 101, 18030-18035 (2004). (Pubitemid 40054069)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.52
, pp. 18030-18035
-
-
Shao, Y.1
Gao, Z.2
Marks, P.A.3
Jiang, X.4
-
36
-
-
0032870475
-
Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
-
DOI 10.1006/mcne.1999.0780
-
Xue, L., Fletcher, G. C. & Tolkovsky, A. M. Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol. Cell Neurosci. 14, 180-198 (1999). (Pubitemid 29449222)
-
(1999)
Molecular and Cellular Neurosciences
, vol.14
, Issue.3
, pp. 180-198
-
-
Xue, L.1
Fletcher, G.C.2
Tolkovsky, A.M.3
-
37
-
-
2442482810
-
Autophagy as a cell death and tumor suppressor mechanism
-
DOI 10.1038/sj.onc.1207521, REV. ISS. 2
-
Gozuacik, D. & Kimchi, A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23, 2891-2906 (2004). (Pubitemid 38638851)
-
(2004)
Oncogene
, vol.23
, Issue.16
, pp. 2891-2906
-
-
Gozuacik, D.1
Kimchi, A.2
-
38
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
DOI 10.1016/j.cell.2005.07.002, PII S0092867405006926
-
Pattingre, S. et al. Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy. Cell 122, 927-939 (2005). (Pubitemid 41345209)
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Xiao, H.L.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
39
-
-
33645512801
-
Bcl-2 inhibition of autophagy: A new route to cancer?
-
Pattingre, S. & Levine, B. Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res. 66, 2885-2888 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 2885-2888
-
-
Pattingre, S.1
Levine, B.2
-
40
-
-
0037395605
-
A brief history of novel drug discovery technologies
-
Gershell, L. J. & Atkins, J. H. A brief history of novel drug discovery technologies. Nat. Rev. Drug Discov. 2, 321-327 (2003). (Pubitemid 37361690)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.4
, pp. 321-327
-
-
Gershell, L.J.1
Atkins, J.H.2
-
41
-
-
79952578695
-
Maximizing the therapeutic window of an antimicrobial drug by imparting mitochondrial sequestration in human cells
-
Pereira, M. P. & Kelley, S. O. Maximizing the therapeutic window of an antimicrobial drug by imparting mitochondrial sequestration in human cells. J. Am. Chem. Soc. 133, 3260-3263 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 3260-3263
-
-
Pereira, M.P.1
Kelley, S.O.2
|