Inhibition of S6K1 enhances dichloroacetate-induced cell death

Journal of Cancer Research and Clinical Oncology

Volumn 141, Issue 7, 2015, Pages 1171-1179

  Hong, Sung Eun ^a,e   Shin, Keong Sub ^b   Lee, Yun Han ^c   Seo, Sung Kum ^a   Yun, Sun Mi ^a   Choe, Tae Boo ^b   Kim, Hyun Ah ^d   Kim, Eun Kyu ^d   Noh, Woo Chul ^d   Kim, Jong Il ^e   Hwang, Chang Sun ^f   Lee, Jin Kyung ^a   Hwang, Sang Gu ^a   Jin, Hyeon Ok ^a   Park, In Chul ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Konkuk University   (South Korea)

^c Yonsei University   (South Korea)

^d Korea Cancer Center Hospital   (South Korea)

^e Seoul Women University   (South Korea)

^f Catholic Kwandong University   (South Korea)

Author keywords

Breast cancer; Dichloroacetate; Glucose metabolism; HK2; S6K1

Indexed keywords

ANTINEOPLASTIC AGENT; DICHLOROACETIC ACID; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PF-4708671; PIPERAZINE DERIVATIVE; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; S6 KINASE; SMALL INTERFERING RNA;

ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL DEATH; CELL PROLIFERATION; DRUG EFFECTS; DRUG POTENTIATION; FEMALE; GENETICS; HUMAN; MCF 7 CELL LINE; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL CULTURE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CELL DEATH; CELL PROLIFERATION; DICHLOROACETIC ACID; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; HUMANS; IMIDAZOLES; MCF-7 CELLS; PIPERAZINES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84938540124     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1887-9     Document Type: Article

References (30)

1. Ayyanathan K, Kesaraju S, Dawson-Scully K, Weissbach H (2012) Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage. PLoS One 7:e39949. doi:10.1371/journal.pone.0039949
2. Barger JF, Gallo CA, Tandon P, Liu H, Sullivan A, Grimes HL, Plas DR (2013) S6K1 determines the metabolic requirements for BCR-ABL survival. Oncogene 32:453–461. doi:10.1038/onc.2012.70
3. Berenbaum MC (1981) Criteria for analyzing interactions between biologically active agents. Adv Cancer Res 35:269–335
4. Bonnet S et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11:37–51. doi:10.1016/j.ccr.2006.10.020
5. Cao W et al (2008) Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate 68:1223–1231. doi:10.1002/pros.20788
6. Cerella C, Dicato M, Diederich M (2014) Modulatory roles of glycolytic enzymes in cell death. Biochem Pharmacol. doi:10.1016/j.bcp.2014.07.005
7. Choi HN et al (2013) Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells. Biochem Biophys Res Commun 432:123–128. doi:10.1016/j.bbrc.2013.01.074
8. Ferreira LM (2010) Cancer metabolism: the Warburg effect today. Exp Mol Pathol 89:372–380. doi:10.1016/j.yexmp.2010.08.006
9. Fingar DC, Blenis J (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151–3171. doi:10.1038/sj.onc.1207542
10. Flavin D (2010) Medullary thyroid carcinoma relapse reversed with dichloroacetate: a case report. Oncol Lett 1:889–891. doi:10.3892/ol_00000158
11. Gimenez-Cassina A, Lim F, Cerrato T, Palomo GM, Diaz-Nido J (2009) Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3. J Biol Chem 284:3001–3011. doi:10.1074/jbc.M808698200
12. Hong SE et al (2013) S6K1 inhibition enhances tamoxifen-induced cell death in MCF-7 cells through translational inhibition of Mcl-1 and survivin. Cell Biol Toxicol 29:273–282. doi:10.1007/s10565-013-9253-2
13. Jha MK, Suk K (2013) Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas. Brain Tumor Res Treat 1:57–63. doi:10.14791/btrt.2013.1.2.57
14. Jin HO, Seo SK, Woo SH, Choe TB, Hong SI, Kim JI, Park IC (2009) Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4. IUBMB Life 61:1153–1158. doi:10.1002/iub.271
15. Kim D, Akcakanat A, Singh G, Sharma C, Meric-Bernstam F (2009) Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors 27:12–21. doi:10.1080/08977190802556986
16. Michelakis ED, Webster L, Mackey JR (2008) Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 99:989–994. doi:10.1038/sj.bjc.6604554
17. Michelakis ED et al (2010) Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med 2:31ra34. doi:10.1126/scitranslmed.3000677
18. Najafov A, Alessi DR (2010) Uncoupling the Warburg effect from cancer. Proc Natl Acad Sci USA 107:19135–19136. doi:10.1073/pnas.1014047107
19. Noh WC et al (2004) Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 10:1013–1023
20. Pearce LR et al (2010) Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J 431:245–255. doi:10.1042/BJ20101024
21. Pelicano H, Martin DS, Xu RH, Huang P (2006) Glycolysis inhibition for anticancer treatment. Oncogene 25:4633–4646. doi:10.1038/sj.onc.1209597
22. Sanchez WY et al (2013) Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib. Br J Cancer 108:1624–1633. doi:10.1038/bjc.2013.120
23. Stockwin LH et al (2010) Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC. Int J Cancer 127:2510–2519. doi:10.1002/ijc.25499
24. Sun RC, Fadia M, Dahlstrom JE, Parish CR, Board PG, Blackburn AC (2010) Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast Cancer Res Treat 120:253–260. doi:10.1007/s10549-009-0435-9
25. Tandon P, Gallo CA, Khatri S, Barger JF, Yepiskoposyan H, Plas DR (2011) Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proc Natl Acad Sci USA 108:2361–2365. doi:10.1073/pnas.1013629108
26. Vander Heiden MG (2011) Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 10:671–684. doi:10.1038/nrd3504
27. Warburg O (1956) On the origin of cancer cells. Science 123:309–314
28. Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I (2008) Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol 109:394–402. doi:10.1016/j.ygyno.2008.01.038
29. Zhao Y, Butler EB, Tan M (2013) Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis 4:e532. doi:10.1038/cddis.2013.60
30. Zheng J (2012) Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (review). Oncol Lett 4:1151–1157. doi:10.3892/ol.2012.928