Medullary thyroid carcinoma relapse reversed with dichloroacetate: A case report

Oncology Letters

Volumn 1, Issue 5, 2010, Pages 889-891

  Flavin, Dana ^a,b  

^a Foundation for Collaborative Medicine and Research   (United States)

^b AMC/co Klinik im Alpenpark   (Germany)

Author keywords

Dichloroacetate; Medullary thyroid carcinoma

Indexed keywords

CALCITONIN; DACARBAZINE; DICHLOROACETIC ACID; DOXORUBICIN; THIAMINE; TUMOR MARKER;

ADULT; ANAMNESIS; ARTICLE; CANCER REGRESSION; CANCER RELAPSE; CASE REPORT; HUMAN; LABORATORY TEST; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; POSITRON EMISSION TOMOGRAPHY; THYROID MEDULLARY CARCINOMA;

EID: 77957598372     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol_00000158     Document Type: Article

References (13)

1. Santarpia L, Ye L and Gagel RF: Beyond RET: potential therapeutic approaches for advanced and metastatic medullary thyroid carcinoma. J Intern Med 266: 99-113, 2009.
2. Cuccuru G: Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma. J Natl Cancer Inst 96: 1006-1014, 2004.
3. Cakir M and Grossman A: Medullary thyroid cancer: molecular biology and novel molecular therapies. Neuroendocrinology 90: 323-348, 2009.
4. Higgins MJ, Forastiere A and Marur S: New directions in the systemic treatment of metastatic thyroid cancer. Oncology 23: 768-775, 2009.
5. Sugawara M, Geffner DL, Martinez D and Hershman JM: Novel treatment of medullary thyroid cancer. Curr Opin Endocrinol Diabetes Obes 16: 367-372, 2009.
6. Fassnacht M, Kreissl MC, Weissmann D and Allolio B: New targets and therapeutic approaches for endocrine malignancies. Pharmacol Ther 123: 117-141, 2009.
7. Spruijt L, Naviaux R, McGowan KA, et al: Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate. Muscle Nerve 24: 916-924, 2001.
8. American Thyroid Association Guidelines Task Force: Medullary thyroid cancer: Management Guidelines of the American Thyroid Association. Thyroid 19: 565-612, 2009.
9. Cheung K: Calcitonin measurement in the evaluation of thyroid nodules in the United States: a cost-effectiveness and decision analysis. Clin Endocrinol Metab 93: 2173-2180, 2008.
10. Stacpoole PW, Lorenz A, Thomas R and Harman E: Dichloroacetate in the treatment of lactic acidosis. Ann Intern Med 108: 58-63, 1988.
11. Warburg O, Wind F and Negelein E: Uber den stoffwechsel von Tumoren im Korper. Klin Woch 5: 829-832, 1926.
12. Stacpoole PW, Henderson GN, Yan Z and James MO: Clinical pharmacology and toxicology of dichloroacetate. Environ Health Perspect 106: 989-994, 1998.
13. Bonnet S, Archer SL, Allalunis-Turner J, et al: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11: 37-57, 2007.