Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei

Cellular Signalling

Volumn 27, Issue 6, 2015, Pages 1102-1109

  Lee, Yun Yeong ^a   Kim, Hong Seok ^a   Lim, In Kyoung ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

PEA 15; Reversal of senescence phenotype; Senescence associated pErk1 2; TPA (12 O tetradecanoylphorbol 13 acetate)

Indexed keywords

CHROMATIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEA15 PROTEIN, HUMAN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN; PROTEIN C FOS; SIGNAL PEPTIDE; SMALL INTERFERING RNA;

ANTAGONISTS AND INHIBITORS; CELL AGING; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN; DOWN REGULATION; DRUG EFFECTS; G1 PHASE CELL CYCLE CHECKPOINT; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PHENOTYPE; PHOSPHORYLATION; RNA INTERFERENCE;

CELL AGING; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN; DOWN-REGULATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHENOTYPE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 84938498749     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.02.014     Document Type: Article

References (26)

1. Campisi J., d'Adda di Fagagna F. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
2. Hayflick L., Moorhead P.S. Exp. Cell Res. 1961, 25:585-621.
3. Lim I.K., Won Hong K., Kwak I.H., Yoon G., Park S.C. Mech. Ageing Dev. 2000, 119:113-130.
4. Lim I.K., Hong K.W., Kwak I.H., Yoon G., Park S.C. Ann. N. Y. Acad. Sci. 2001, 928:176-181.
5. Kim H.S., Song M.C., Kwak I.H., Park T.J., Lim I.K. J. Biol. Chem. 2003, 278:37497-37510.
6. Kwak I.H., Kim H.S., Choi O.R., Ryu M.S., Lim I.K. Cancer Res. 2004, 64:572-580.
7. Nishizuka Y. Science 1992, 258:607-614.
8. Jaken S. Curr. Opin. Cell Biol. 1990, 2:192-197.
9. Chang L., Karin M. Nature 2001, 410:37-40.
10. Cruzalegui F.H., Cano E., Treisman R. Oncogene 1999, 18:7948-7957.
11. Chen R.H., Sarnecki C., Blenis J. Mol. Cell. Biol. 1992, 12:915-927.
12. Roskoski R. Pharmacol. Res. 2012, 66:105-143.
13. Formstecher E., Ramos J.W., Fauquet M., Calderwood D.A., Hsieh J.C., Canton B., Nguyen X.T., Barnier J.V., Camonis J., Ginsberg M.H., Chneiweiss H. Dev. Cell 2001, 1:239-250.
14. Araujo H., Danziger N., Cordier J., Glowinski J., Chneiweiss H. J. Biol. Chem. 1993, 268:5911-5920.
15. Gaumont-Leclerc M.F., Mukhopadhyay U.K., Goumard S., Ferbeyre G. J. Biol. Chem. 2004, 279:46802-46809.
16. Kubes M., Cordier J., Glowinski J., Girault J.A., Chneiweiss H. J. Neurochem. 1998, 71:1307-1314.
17. Renganathan H., Vaidyanathan H., Knapinska A., Ramos J.W. Biochem. J. 2005, 390:729-735.
18. Krueger J., Chou F.L., Glading A., Schaefer E., Ginsberg M.H. Mol. Biol. Cell 2005, 16:3552-3561.
19. Kim H.S., Lim I.K. J. Biol. Chem. 2009, 284:15475-15486.
20. Boulton T.G., Nye S.H., Robbins D.J., Ip N.Y., Radziejewska E., Morgenbesser S.D., DePinho R.A., Panayotatos N., Cobb M.H., Yancopoulos G.D. Cell 1991, 65:663-675.
21. Wilson S.E., He Y.G., Weng J., Zieske J.D., Jester J.V., Schultz G.S. Exp. Eye Res. 1994, 59:665-678.
22. Trencia A., Perfetti A., Cassese A., Vigliotta G., Miele C., Oriente F., Santopietro S., Giacco F., Condorelli G., Formisano P., Beguinot F. Mol. Cell. Biol. 2003, 23:4511-4521.
23. Lerner-Marmarosh N., Miralem T., Gibbs P.E., Maines M.D. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:6870-6875.
24. Khokhlatchev A.V., Canagarajah B., Wilsbacher J., Robinson M., Atkinson M., Goldsmith E., Cobb M.H. Cell 1998, 93:605-615.
25. Adachi M., Fukuda M., Nishida E. EMBO J. 1999, 18:5347-5358.
26. Matsubayashi Y., Fukuda M., Nishida E. J. Biol. Chem. 2001, 276:41755-41760.