Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: Identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro

Journal of Neurochemistry

Volumn 71, Issue 3, 1998, Pages 1307-1314

  Kubes, Miroslav ^a,b   Cordier, Jocelyne ^a   Glowinski, Jacques ^a   Girault, Jean Antoine ^a   Chneiweiss, Hervé ^a  

^a PSL Research University   (France)

^b INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

Calcium calmodulin kinase II; Casein kinase II; Endothelin; Glia; Protein kinase C; Protein phosphatase

Indexed keywords

CALCIUM ION; CASEIN KINASE II; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 3; OKADAIC ACID; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORUS 32; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; SERINE;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CELL FRACTIONATION; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; MOUSE; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALIA;

EID: 0031819445     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71031307.x     Document Type: Article

References (33)

1. Araujo H., Danzinger N., Cordier J., Glowinski J., and Chneiweiss H. (1993) Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J. Biol. Chem. 268, 5911-5920.
2. Birman S., Cordier J., Glowinski J., and Chneiweiss H. (1989) Cyclic AMP dependent protein kinase in mouse striatal neurones and astrocytes in primary culture: development, subcellular distribution and stimulation of endogenous phosphorylation. Neurochem. Int. 14, 25-34.
3. Cazaubon S. M., Ramos-Morales F., Fischer S., Schweighoffer F., Strosberg D. A., and Couraud P. (1994) Endothelin induces tyrosine phosphorylation and GRB2 associations of Shc in astrocytes. J. Biol. Chem. 269, 24805-24809.
4. Cazaubon S. M., Chaverot N., Romero I. A., Girault J. A., Adamson P., Strosberg D. A., and Couraud P. (1997) Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways. J. Neurosci. 17, 6203-6212.
5. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
6. Danziger N., Yokoyama M., Jay T., Cordier J., Glowinski J., and Chneiweiss H. (1995) Cellular expression, developmental regulation, and phylogenic conservation of PEA-15: the astrocytic major phosphoprotein and protein kinase C substrate. J. Neurochem. 64, 1016-1025.
7. Desagher S., Cordier J., Glowinski J., and Tencé M. (1997) Endothelin stimulates phospholipase D in striatal astrocytes. J. Neurochem. 68, 78-87.
8. Estelles A., Yokoyama M., Nothias F., Vincent J., Glowinski J., Vernier P., and Chneiweiss H. (1996) The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human. J. Biol. Chem. 271, 14800-14806.
9. Fraser A. and Evans G. (1996) A license to kill. Cell 85, 781-784.
10. 2+/calmodulin-dependent protein kinase II in rat brain and various tissues. J. Neurochem. 51, 1070-1078.
11. Garrels J. I. (1979) Two-dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines. J. Biol. Chem. 254, 7961-7977.
12. Girault J., Hemmings H. C., Williams K. R., Nairn A. C., and Greengard P. (1989) Phosphorylation of DARPP-32, a dopamine and cAMP-regulated phosphoprotein, by casein kinase II. J. Biol. Chem. 264, 21748-21759.
13. Hemmings H. C., Nairn A. C., and Greengard P. (1984) DARPP-32, a dopamine and adenosine 3′:5′-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1. J. Biol. Chem. 259, 14491-14497.
14. Hunter T. (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80, 225-236.
15. Kennely P. J. and Krebs E. G. (1991) Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266, 15555-15558.
16. Ladenheim R. G., Lacroix I., Foignant-Chaverot N., Strosberg A. D., and Couraud P. (1993) Endothelins stimulate c-fos and nerve growth expression in astrocytes and astrocytoma. J. Neurochem. 60, 260-266.
17. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
18. B endothelin receptor to mitogen-activated protein kinase stimulation and DNA synthesis in primary cultures of rat astrocytes. J. Neurochem. 66, 459-465.
19. MacCumber M., Ross C., and Snyder S. H. (1990) Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells. Proc. Natl. Acad. Sci. USA 87, 2359-2363.
20. Marin P., Delumeau J. C., Duneu-Trautman O., Le Nguyen D., Prémont J., Strosberg D. A., and Couraud P. (1991) Are several G proteins involved in the different effects of endothelin-1 in mouse striatal astrocytes? J. Neurochem. 56, 1270-1275.
21. 2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 260, 1696-1704.
22. Ouimet C. C., McGuinness T. L., and Greengard P. (1984) Immunocytochemical localization of calcium/calmodulin-dependent protein kinase II in rat brain. Proc. Natl. Acad. Sci. USA 81, 5604-5608.
23. Pearson R. B. and Kemp B. E. (1991) Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations, in Protein Phosphorylation (Hunter T. and Sefton B. M., eds), pp. 62-81. Academic Press, San Diego.
24. Pearson R. B., Woodget J. R., Cohen P., and Kemp B. (1985) Substrate specificity of a multifunctional calmodulin-dependent protein kinase. J. Biol. Chem. 260, 14471-14476.
25. Rowles J., Slaughter C., Moomaw C., Hsu J., and Cobb M. H. (1991) Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes. Proc. Natl. Acad. Sci. USA 88, 9548-9552.
26. 2+ on in vitro astrocyte injury. J. Neurochem. 68, 289-296.
27. 2+/calmodulin-dependent protein kinase II in cultures of hippocampal pyramidal neurons and astrocytes. J. Neurosci. 8, 1039-1051.
28. Smith S. J. (1994) Neuromodulatory astrocytes. Curr. Biol. 4, 807-810.
29. Stanimirovic D. B., Ball R., Mealing G., Morley P., and Durkin J. P. (1995) The role of intracellular calcium and protein kinase C in endothelin-stimulated proliferation of rat type 1 astrocytes. Glia 15, 119-130.
30. Suppattapone S. and Ashley C. C. (1991) Endothelin opens potassium channels in glial cells. Eur. J. Neurosci. 3, 349-355.
31. Venance L., Siciliano J. C., Yokoyama M., Cordier J., Glowinski J., and Giaume C. (1995) Inhibition of Astrocyte Gap Junctions by Endothelins. Elsevier Science, Amsterdam.
32. Wera S.and Hemmings B. A. (1995) Serine/threonine protein phosphatases. Biochem. J. 311, 17-29.
33. 2+/calmodulin-dependent protein kinase II and phosphorylation of intermediate filament proteins by stimulation of glutamate receptors in cultured rat cortical astrocytes. J. Biol. Chem. 269, 5428-5439.