Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate Sp1 on serine 59 and regulate cellular senescence via transcription of p21Sdi1/Cip1/Waf1

Journal of Biological Chemistry

Volumn 284, Issue 23, 2009, Pages 15475-15486

  Kim, Hong Seok ^a   Lim, In Kyoung ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; CELLULAR SENESCENCE; EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASE; HUMAN DIPLOID FIBROBLASTS; IN-VIVO; INHIBITOR ANALYSIS; NULL CONDITION; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES;

AMINO ACIDS; CELL CULTURE; CELL PROLIFERATION; FIBROBLASTS; OXYGEN; PHOSPHORYLATION; SIMULATED ANNEALING; TRANSCRIPTION;

CELL MEMBRANES;

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; GLUTATHIONE TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; REACTIVE OXYGEN METABOLITE; SERINE; SHORT HAIRPIN RNA; THREONINE; TRANSCRIPTION FACTOR SP1; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PRIMER DNA; PROTEIN KINASE; SMALL INTERFERING RNA; SP1 KINASE;

AGE DISTRIBUTION; ARTICLE; CELL AGING; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DIPLOIDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FIBROBLAST; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RESIDUE ANALYSIS; SENESCENCE; CELL DIVISION; CELL NUCLEUS; CYTOLOGY; CYTOPLASM; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

CELL AGING; CELL DIVISION; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOPLASM; DNA PRIMERS; FIBROBLASTS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SERINE; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 67650188593     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808734200     Document Type: Article

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