Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

Biochemical Journal

Volumn 390, Issue 3, 2005, Pages 729-735

  Renganathan, Hemamalini ^a   Vaidyanathan, Hema ^a   Knapinska, Anna ^a   Ramos, Joe W ^b  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Calcium calmodulin dependent protein kinase II (CamKII); ERK (extracellular signal regulated kinase) MAPK (mitogen activated protein kinase); PEA 15; Phosphorylation; Protein kinase C; Signal transduction

Indexed keywords

ANTIBODIES; BIOCHEMISTRY; CELLS; PROTEINS;

ERK; PEA-15; PHOSPHORYLATION; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

PHOSPHORUS;

EPITOPE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN PEA 15; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME REGULATION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CELL NUCLEUS; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; SUBSTRATE SPECIFICITY; TETRADECANOYLPHORBOL ACETATE;

EID: 25844522837     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050378     Document Type: Article

References (19)

1. Formstecher, E., Ramos, J. W., Fauquet, M., Calderwood, D. A., Hsieh, J. C., Canton, B., Nguyen, X. T., Barnier, J. V., Camonis, J., Ginsberg, M. H. et al. (2001) PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev. Cell 1, 239-250
2. Ramos, J. W., Hughes, P. E., Renshaw, M. W., Schwartz, M. A., Formstecher, E., Chneiweiss, H. and Ginsberg, M. H. (2000) Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism. Mol. Biol. Cell 11, 2863-2872
3. Ramos, J. W. (2005) PEA-15 phosphoprotein: a potential cancer drug target. Hawaii Med. J. 64, 77-79
4. Condorelli, G., Vigliotta, G., Cafieri, A., Trencia, A., Andalo, P., Oriente, F., Miele, C., Caruso, M., Formisano, P. and Beguinot, F. (1999) PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis. Oncogene 18, 4409-4415
5. Estelles, A., Charlton, C. A. and Blau, H. M. (1999) The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev. Biol. 216, 16-28
6. Kitsberg, D., Formstecher, E., Fauquet, M., Kubes, M., Cordier, J., Canton, B., Pan, G., Rolli, M., Glowinski, J. and Chneiweiss, H. (1999) Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. J. Neurosci. 19, 8244-8251
7. Trencia, A., Fiory, F., Maitan, M. A., Vito, P., Barbagallo, A. P., Perfetti, A., Miele, C., Ungaro, P., Oriente, F, Cilenti, L. et al. (2004) Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15. J. Biol. Chem. 279, 46566-46572
8. Araujo, H., Danziger, N., Cordier, J., Glowinski, J. and Chneiweiss, H. (1993) Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J. Biol. Chem. 268, 5911-5920
9. Kubes, M., Cordier, J., Glowinski, J., Girault, J. A. and Chneiweiss, H. (1998) Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro. J. Neurochem. 71, 1307-1314
10. Trencia, A., Perfetti, A., Cassese, A., Vigliotta, G., Miele, C., Oriente, F., Santopietro, S., Giacco, F., Condorelli, G., Formisano, P. et al. (2003) Protein kinase B/AKT binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action. Mol. Cell. Biol. 23, 4511-4521
11. Chou, F. L., Hill, J. M., Hsieh, J. C., Pouyssegur, J., Brunet, A., Glading, A., Uberall, F., Ramos, J. W., Werner, M. H. and Ginsberg, M. H. (2003) PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. J. Biol. Chem. 278, 52587-52597
12. Condorelli, G., Vigliotta, G., Iavarone, C., Caruso, M., Tocchetti, C. G., Andreozzi, F., Cafieri, A., Tecce, M. F., Formisano, P., Beguinot, L. et al. (1998) PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. EMBO J. 17, 3858-3866
13. Condorelli, G., Vigliotta, G., Trencia, A., Maitan, M. A., Caruso, M., Miele, C., Oriente, F., Santopietro, S., Formisano, P. and Beguinot, F. (2001) Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells. Diabetes 50, 1244-1252
14. Hao, C., Beguinot, F., Condorelli, G., Trencia, A., Van Meir, E. G., Yong, V. W., Parney, I. F., Roa, W. H. and Petruk, K. C. (2001) Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apoptosis in human malignant glioma cells. Cancer Res. 61, 1162-1170
15. Xiao, C., Yang, B. F., Asadi, N., Beguinot, F. and Hao, C. (2002) Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. J. Biol. Chem. 277, 25020-25025
16. Hill, J. M., Vaidyanathan, H., Ramos, J. W., Ginsberg, M. H. and Werner, M. H. (2002) Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J. 21, 6494-6504
17. Ramos, J. W., Kojima, T. K., Hughes, P. E., Fenczik, C. A. and Ginsberg, M. H. (1998) The death effector domain of PEA-15 is involved in its regulation of integrin activation. J. Biol. Chem. 273, 33897-33900
18. Vaidyanathan, H. and Ramos, J. W. (2003) RSK2 activity is regulated by its interaction with PEA-15. J. Biol. Chem. 278, 32367-32372
19. Whitehurst, A. W., Robinson, F. L., Moore, M. S. and Cobb, M. H. (2004) The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. J. Biol. Chem. 279, 12840-12847