Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 3, 2015, Pages 412-423

  Wu, Dongsheng ^a   Cerutti, Camilla ^a   Lopez Ramirez, Miguel A ^a,b   Pryce, Gareth ^c   King Robson, Josh ^c   Simpson, Julie E ^d   Van Der Pol, Susanne M A ^e   Hirst, Mark C ^a   De Vries, Helga E ^e   Sharrack, Basil ^f   Baker, David ^c   Male, David K ^a   Michael, Gregory J ^c   Romero, Ignacio A ^a  

^a OPEN UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

adhesion molecules; blood brain barrier; endothelium; gene regulation; multiple sclerosis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MICRORNA 146A; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; MICRORNA; MIRN146 MICRORNA, HUMAN; MIRN146 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CAPILLARY ENDOTHELIAL CELL; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MICROVASCULATURE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; T LYMPHOCYTE; UPREGULATION; ADULT; AGED; ANIMAL; CYTOLOGY; FEMALE; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IN SITU HYBRIDIZATION; INFLAMMATION; LASER CAPTURE MICRODISSECTION; MALE; METABOLISM; MIDDLE AGED; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CELL ADHESION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOTHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION; LASER CAPTURE MICRODISSECTION; MALE; MICE; MICRORNAS; MIDDLE AGED; MULTIPLE SCLEROSIS; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TRANSFECTION;

EID: 84938496871     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.207     Document Type: Article

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