TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3β

Cell Death and Differentiation

Volumn 15, Issue 4, 2008, Pages 730-738

  Yoon, K ^a   Jung, E J ^a   Lee, S R ^a   Kim, J ^a   Choi, Y ^b   Lee, S Y ^a  

^a Ewha Womans University   (South Korea)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

3T3 CELLS; ANIMALS; CELL DEATH; CELL SURVIVAL; DOWN-REGULATION; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FIBROBLASTS; GLYCOGEN SYNTHASE KINASE 3; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TNF RECEPTOR-ASSOCIATED FACTOR 2; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR RELA; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 40949110878     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402304     Document Type: Article

References (39)

1. Aggarwal BB. Signalling pathways of theTNF superfamily: A double-edged sword. Nat Rev Immunol 2003; 3: 745-756.
2. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell 2001; 104 487-501.
3. Chen G, Goeddel DV. TNF-R1 signaling: A beautiful pathway. Science 2002; 296: 1634-1635.
4. Hsu T, Huang J, Shu HB, Baichwal V, Goeddel DV. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 1996; 4: 387-396.
5. Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996; 84: 299-308.
6. Yoh WC, Shahinian A, Speiser D, Kraunus J, Billia F, Wakeham A et al Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 1997; 7: 715-725.
7. Deng Y, Ran X, Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNFα-induced apoptosis. Cell 2003; 115: 61-70.
8. Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y et al. NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 2003; 22: 3898-3909.
9. Bubici C, Papa S, Dean K, Franzoso G. Mutual cross-talk between reactive oxygen species and nuclear factor-κB: Molecular basis and biological significance. Oncogene 2006; 25: 6731-6748.
10. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649-661.
11. Arch PH, Gedrich RW, Thompson CB. Tumor necrosis factor roceptor-associated factors (TRAFs) - a family of adapter proteins that regulates life and death. Genes Dev 1998; 12: 2821-2830.
12. Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 2001; 20: 6482-6491.
13. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T et al Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997; 275: 90-94.
14. Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an lκB kinase. Cell 1997; 90: 373-383.
15. Xu LG, Li LY, Shu HB. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem 2004; 279: 17278-17282.
16. Wu H, Arron JR. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays 2003; 25: 1096-1105.
17. Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003; 300: 524-1525.
18. Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 1999; 13: 1015-1024.
19. Ichikawa D, Funakoshi-Tago M, Aizu-Yokota E, Sonoda Y, Inoue J, Kasahara T. TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-α-induced cell death: Involvement of reactive oxygen species. Biochem Biophys Res Commun 2006; 351: 93-98.
20. Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzweig MC, Choi Y. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity 1997; 7: 703-713.
21. Nakano H, Nakajima A, Sakon-Komazawa S, Piao JH, Xue X, Okumura K. Reactive oxygen species mediate crosstalk between NF-κB and JNK. Cell Death Differ 2006; 13: 730-737.
22. Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K et al. Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species. Cell 2004; 119: 529-542.
23. Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S et al Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death. J Biol Chem 2001; 276: 36530-36534.
24. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin 0, Woodgett JR. Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation. Nature 2000; 406: 86-90.
25. Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-κB and lκB proteins: Implications in cancer and inflammation. Trends Biochem Sci 2005; 30: 43-52.
26. Schmitz ML, Mattioli I, Buss H, Kracht M. NF-κB: A multifaceted transcription factor regulated at several levels. Chem Bio Chem 2004; 5: 1348-1358.
27. Nguyen LT, Duncan GS, Mirtsos C, Ng M, Speiser DE, Shahinian A et al TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. Immunity 1999; 11 379-389.
28. Davies CC, Mak TW, Young LS, Eliopoulos AG. TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol Cell Biol 2005; 25: 9806-9819.
29. Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, Doi T, Saiki I. TNFa-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem 2003; 278: 36916-36923.
30. Frame S, Cohen P. GSK3 takes centre stage more 20 years after its discovery. Biochem J 2001; 359: 1-16.
31. Woodgett JR. Judging a protein by more than its name: GSK-3. Sci STKE 2001; 2001: RE12.
32. Ozes ON, Mayo LD, Gustin JA, Pleffer SR, Pleffer LM, Donner DB. NF-KB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999; 401: 82-85.
33. Kane LP, Shapiro VS, Stokoe D, Weiss A. Induction of NF-KB by the Akt/ PKB kinase. Curr Biol 1999; 9: 601-604.
34. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004; 15: 177-182.
35. Schwabe RF, Brenner DA. Role of glycogen synthase kinase-3 in TNF-α-induced NF-KB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002; 283: G204-G211.
36. Woodgett JR, Ohashi PS. GSK3: An in-Toll-erant protein kinase? Nat Immunol 2005; 6: 751-752.
37. Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005; 6: 777-784.
38. King CG, Kobayashi T, Cejas PJ, Kim T, Yoon K, Kim GK et al. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med 2006; 12: 1088-1092.
39. Todaro GJ, Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 1963; 17: 299-313.