Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21Waf1/Cip1 mediated inhibition of Hh-Gli signaling

International Journal of Biochemistry and Cell Biology

Volumn 66, Issue , 2015, Pages 75-84

  Mohapatra, Purusottam ^a   Satapathy, Shakti Ranjan ^a   Siddharth, Sumit ^a   Das, Dipon ^a   Nayak, Anmada ^a   Kundu, Chanakya Nath ^a  

^a KIIT UNIVERSITY   (India)

Author keywords

Combination therapy; Curcumin; Hh Gli Signaling; MCF 10A Tr; p21Waf Cip1; Resveratrol

Indexed keywords

BETA CATENIN; CASPASE 3; CIGARETTE SMOKE CONDENSATE; CURCUMIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; DNA; GLI PROTEIN; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH RECEPTOR; PROTEIN BAX; PROTEIN BCL XL; RESVERATROL; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GLI1 PROTEIN, HUMAN; PROTEIN BCL X; SHH PROTEIN, HUMAN; SMOKE; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM CELL; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CLONOGENIC ASSAY; COLONY FORMATION; CONTROLLED STUDY; DNA CONTENT; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME DEGRADATION; EXCISION REPAIR; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC50; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CELL LINE; CELL TRANSFORMATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; EPITHELIUM CELL; GENETICS; METABOLISM; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOKE; TOBACCO; TOXICITY;

ERINACEIDAE; MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BREAST NEOPLASMS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CURCUMIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG SYNERGISM; EPITHELIAL CELLS; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOBLOTTING; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOKE; STILBENES; TOBACCO; TRANSCRIPTION FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84938340836     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2015.07.009     Document Type: Article

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