Exposure to nicotine produces an increase in dopamine D2 High receptors: A possible mechanism for dopamine hypersensitivity

International Journal of Neuroscience

Volumn 120, Issue 11, 2010, Pages 691-697

  Novak, Gabriela ^a,b   Seeman, Philip ^b   Foll, Bernard Le ^a,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Family and Community Medicine Psychiatry Pharmacology   (Canada)

Author keywords

Basal ganglia; Cigarette; D2 High; dopamine; incentive; nicotine; sensitization; smoking; tobacco

Indexed keywords

DOPAMINE; DOPAMINE 2 RECEPTOR; NICOTINE;

ABSTINENCE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DEPENDENCE; DRUG SELF ADMINISTRATION; DRUG WITHDRAWAL; HYPERSENSITIVITY; MALE; NONHUMAN; RAT; SENSITIZATION;

ANIMALS; BEHAVIOR, ANIMAL; CORPUS STRIATUM; DOMPERIDONE; DOPAMINE; HUMANS; MALE; NICOTINE; RATS; RATS, LONG-EVANS; RECEPTORS, DOPAMINE D2; SELF ADMINISTRATION; SUBSTANCE WITHDRAWAL SYNDROME; TRITIUM; UP-REGULATION;

EID: 77958022460     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2010.513462     Document Type: Article

References (26)

1. Balfour, D. J., Wright, A. E., Benwell, M. E., & Birrell, C. E. (2000). The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. Behavioural Brain Research, 113(1-2), 73-83. [PubMed 10942034]
2. Birrell, C. E., & Balfour, D. J. (1998). The infuence of nicotine pretreatment on mesoaccumbens dopamine overfow and loco-motor responses to D-amphetamine. Psychopharmacology (Berl), 140(2), 142-149. [PubMed 9860104]
3. Briand, L. A., Flagel, S. B., Seeman, P., & Robinson, T. E. (2008). Cocaine self-administration produces a persistent increase in dopamine D2 High receptors. European Journal of Neuropsy-chopharmacology, 18(8), 551-556. [PubMed 18284941]
4. Corrigall, W. A., & Coen, K. M. (1989). Nicotine maintains robust self-administration in rats on a limited-access schedule. Psy-chopharmacology (Berl), 99(4), 473-478. [PubMed 2594913]
5. Fehr, C., Yakushev, I., Hohmann, N., Buchholz, H. G., Landvogt, C., Deckers, H., et al. (2008). Association of low-striatal dopamine D2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. The American Journal of Psychiatry, 165(4), 507-514. [PubMed 18316420]
6. Fung, Y. K. (1989). Effects of chronic nicotine pretreatment on (+)-amphetamine and nicotine-induced synthesis and release of [3H]dopamine from [3H]tyrosine in rat nucleus accumbens. The Journal of Pharmacy and Pharmacology, 41(1), 66-68. [PubMed 2565971]
7. Ksir, C., Hakan, R. L., & Kellar, K. J. (1987). Chronic nicotine and locomotor activity: Infuences of exposure dose and test dose. Psychopharmacology (Berl), 92(1), 25-29. [PubMed 3110825]
8. ? nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. Biological Psychiatry, 65(8), 714-716. [PubMed 19095220]
9. Le Foll, B., Diaz, J., & Sokoloff, P. (2003). Increased dopamine D3 receptor expression accompanying behavioural sensitization to nicotine in rats. Synapse, 47(3), 176-183. [PubMed 12494400]
10. Le Foll, B., & Goldberg, S. R. (2006). Nicotine as a typical drug of abuse in experimental animals and humans. Psychopharmacology (Berl.), 184(3-4), 367-381. [PubMed 16205918]
11. Marcellino, D., Ferre, S., Casado, V., Cortes, A., Le Foll, B., Mazzola, C., et al. (2008). Identifcation of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. The Journal of Biological Chemistry, 283(38), 26016-26025. [PubMed 18644790]
12. Nader, M. A., Morgan, D., Gage, H. D., Nader, S. H., Calhoun, T. L., Buchheimer, N., et al. (2006). PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nature Neuroscience, 9(8), 1050-1056. [PubMed 16829955]
13. Novak, G., & Seeman, P. (2010). Hyperactive mice show elevated D2High receptors, a model for schizophrenia: calcium/calmodulin-dependent kinase II alpha knockouts. Synapse, 64(10), 794-800. [PubMed: 20336626]
14. Picciotto, M. R., & Corrigall, W. A. (2002). Neuronal systems underlying behaviors related to nicotine addiction: Neural circuits and molecular genetics. The Journal of Neuroscience, 22(9), 3338-3341. [PubMed 11978809]
15. Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997). Nicotine activates and desensitizes midbrain dopamine neurons. Nature, 390(6658), 401-404. [PubMed 9389479]
16. Pontieri, F. E., Tanda, G., Orzi, F., & Di Chiara, G. (1996). Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature, 382(6588), 255-257. [PubMed 8717040]
17. Rahman, S., Zhang, J., Engleman, E. A., & Corrigall, W. A. (2004). Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: A microdialysis study. Neuroscience, 129(2), 415-424. [PubMed 15501598]
18. Robinson, T. E., & Berridge, K. C. (1993). The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Research Reviews, 18(3), 247-291. [PubMed 8401595]
19. Seeman, P., Guan, H. C., & Hirbec, H. (2009). Dopamine D2 High receptors stimulated by phencyclidines, lysergic acid diethy-lamide, salvinorin A, and modafnil. Synapse, 63(8), 698-704. [PubMed 19391150]
20. Seeman, P., Schwarz, J., Chen, J. F., Szechtman, H., Perreault, M., McKnight, G. S., et al. (2006). Psychosis pathways converge via D2high dopamine receptors. Synapse, 60(4), 319-346. [PubMed 16786561]
21. Seeman, P., Tallerico, T., Ko, F., Tenn, C., & Kapur, S. (2002). Amphetamine-sensitized animals show a marked increase in dopamine D2 High receptors occupied by endogenous dopamine, even in the absence of acute challenges. Synapse, 46(4), 235-239. [PubMed 12373738]
22. Seeman, P., Weinshenker, D., Quirion, R., Srivastava, L. K., Bhard-waj, S. K., Grandy, D. K., et al. (2005). Dopamine supersensi-tivity correlates with D2 High states, implying many paths to psy-chosis. Proceedings of the National Academy of Sciences of the United States of America, 102(9), 3513-3518. [PubMed 15716360]
23. Suemaru, K., Gomita, Y., Furuno, K., & Araki, Y. (1993). Chronic nicotine treatment potentiates behavioral responses to dopamin-ergic drugs in rats. Pharmacology, Biochemistry, and Behavior, 46(1), 135-139. [PubMed 7902980]
24. Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009). Imaging dopamine's role in drug abuse and addiction. Neuropharmacology, 56(Suppl 1), 3-8. [PubMed 18617195]
25. Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Gatley, S. J., Gifford, A., et al. (1999). Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. American Journal of Psychiatry, 156(9), 1440-1443. [PubMed 10484959]
26. Wang, G. J., Volkow, N. D., Chang, L., Miller, E., Sedler, M., Hitzemann, R., et al. (2004). Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence. American Journal of Psychiatry, 161(2), 242-248. [PubMed 19095220]