Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

Journal of Diabetes Research

Volumn 2015, Issue , 2015, Pages

  Yu, Sung Hsun ^a,b   Chen, Szu Yu Tina ^b   Li, Wei Shan ^b   Dubey, Navneet Kumar ^b   Chen, Wei Hong ^b   Chuu, Jiunn Jye ^c   Leu, Sy Jye ^a   Deng, Win Ping ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; CHOLESTEROL; CORDYCEPS MILITARIS EXTRACT; GLUCOSE TRANSPORTER 4; HYPOCHOLESTEROLEMIC AGENT; INSULIN RECEPTOR SUBSTRATE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; PROTEIN KINASE B; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; PLANT MEDICINAL PRODUCT; SLC2A4 PROTEIN, MOUSE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BLOOD BIOCHEMISTRY; BODY WEIGHT; CONTROLLED STUDY; CORDYCEPS; DIET RESTRICTION; FRUITING BODY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; MYCELIUM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; METABOLISM; PHOSPHORYLATION; WESTERN BLOTTING;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CHOLESTEROL; CORDYCEPS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FRUITING BODIES, FUNGAL; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; MYCELIUM; PHOSPHORYLATION; PLANT PREPARATIONS; PPAR GAMMA; PROTO-ONCOGENE PROTEINS C-AKT; TRIGLYCERIDES;

EID: 84938236841     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2015/723190     Document Type: Article

References (68)

1. E. Morales Villegas, "Syndrome X vs metabolic syndrome, " Archivos de Cardiologá de México, vol. 76, supplement 4, pp. S173-S188, 2006.
2. K. L. Tucker and S. Buranapin, "Nutrition and aging in developing countries, "The Journal of Nutrition, vol. 131, no. 9, pp. 2417S-2423S, 2001.
3. T. Nakamura, T. Terajima, T. Ogata et al., "Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide, " Biological and Pharmaceutical Bulletin, vol. 29, no. 6, pp. 1167-1174, 2006.
4. T. Szkudelski, "Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model, " Experimental Biology and Medicine, vol. 237, no. 5, pp. 481-490, 2012.
5. L. Boquist, B. Hellman, A. Lernmark, and I. B. Taljedal, "Influence of the mutation 'diabetes' on insulin release and islet morphology in mice of different genetic backgrounds, " Journal of Cell Biology, vol. 62, no. 1, pp. 77-89, 1974.
6. E. Shafrir, "Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia, " Diabetes and Metabolism, vol. 22, no. 2, pp. 122-131, 1996.
7. V. R. Drel, N. Mashtalir, O. Ilnytska et al., "The leptin-deficient (ob/ob)mouse: a newanimal model of peripheral neuropathy of type 2 diabetes and obesity, " Diabetes, vol. 55, no. 12, pp. 3335-3343, 2006.
8. S. R. Commerford, M. E. Bizeau, H. McRae, A. Jampolis, J. S. Thresher, and M. J. Pagliassotti, "Hyperglycemia compensates for diet-induced insulin resistance in liver and skeletal muscle of rats, " The American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 281, no. 5, pp. R1380-R1389, 2001.
9. X. Zhang, Y. Cui, L. Fang, and F. Li, "Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats, " Pancreas, vol. 37, no. 3, pp. e31-e38, 2008.
10. P. I. Parekh, A. E. Petro, J. M. Tiller, M. N. Feinglos, and R. S. Surwit, "Reversal of diet-induced obesity and diabetes in C57BL/6J mice, "Metabolism: Clinical and Experimental, vol. 47, no. 9, pp. 1089-1096, 1998.
11. U. Hoffler, K. Hobbie, R. Wilson et al., "Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy inC57Bl/6J mice, " Endocrine, vol. 36, no. 2, pp. 311-325, 2009.
12. M. E. Shaul, G. Bennett, K. J. Strissel, A. S. Greenberg, and M. S. Obin, "Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet- induced obesity in mice, " Diabetes, vol. 59, no. 5, pp. 1171-1181, 2010.
13. G. M. Reaven, "Why Syndrome X From Harold Himsworth to the insulin resistance syndrome, " Cell Metabolism, vol. 1, no. 1, pp. 9-14, 2005.
14. R. S. Sherwin, "Role of the liver in glucose homeostasis, " Diabetes Care, vol. 3, no. 2, pp. 261-265, 1980.
15. R. A. DeFronzo, "Obesity is associated with impaired insulinmediated potassiumuptake, " Metabolism, vol. 37, no. 2, pp. 105-108, 1988.
16. H. Florez, J. Luo, S. Castillo-Florez et al., "Impact ofmetformininduced gastrointestinal symptoms on quality of life and adherence in patients with type 2 diabetes, " Postgraduate Medicine, vol. 122, no. 2, pp. 112-120, 2010.
17. D. S. H. Bell, H. R. Patil, and J. H. O'Keefe, "Divergent effects of various diabetes drugs on cardiovascular prognosis, " Reviews in Cardiovascular Medicine, vol. 14, no. 2-4, pp. e107-e122, 2013.
18. J. Kung and R. R. Henry, "Thiazolidinedione safety, " Expert Opinion on Drug Safety, vol. 11, no. 4, pp. 565-579, 2012.
19. P. Hollander, "Safety profile of acarbose, an alpha-glucosidase inhibitor, " Drugs, vol. 44, supplement 3, pp. 47-53, 1992.
20. Y. Bando, Y. Ushiogi, D. Toya, N. Tanaka, and M. Fujisawa, "Three diabetic cases of acute dizziness due to initial administration of voglibose, " Internal Medicine, vol. 37, no. 9, pp. 753-756, 1998.
21. J. K. H. Cheung, J. Li, A. W. H. Cheung et al., "Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines, " Journal of Ethnopharmacology, vol. 124, no. 1, pp. 61-68, 2009.
22. T. Ohmori, K. Tamura, N. Ohgane et al., "The correlation between molecular weight and antitumor activity of galactosaminoglycan (CO-N) from Cordyceps ophioglossoides, " Chemical and Pharmaceutical Bulletin, vol. 37, no. 5, pp. 1337-1340, 1989.
23. T. Kiho, Y. Shiose, K. Nagai, and S. Ukai, "Polysaccharides in fungi. XXX. Antitumor and immunomodulating activities of two polysaccharides from the fruiting bodies of Armillariella tabescens, " Chemical and Pharmaceutical Bulletin, vol. 40, no. 8, pp. 2110-2114, 1992.
24. J.-S. Zhu, G. M. Halpern, and K. Jones, "The scientific rediscovery of an ancient Chinese herbal medicine: cordyceps sinensis part I, " Journal of Alternative and ComplementaryMedicine, vol. 4, no. 3, pp. 289-303, 1998.
25. J.-S. Zhu, G. M. Halpern, and K. Jones, "The scientific rediscovery of a precious ancient Chinese herbal regimen: cordyceps sinensis: part II, " Journal of Alternative and Complementary Medicine, vol. 4, no. 4, pp. 429-457, 1998.
26. T. Kiho, K. Ookubo, S. Usui, S. Ukai, and K. Hirano, "Structural features and hypoglycemic activity of a polysaccharide (CS-F10) from the cultured mycelium of Cordyceps sinensis, " Biological and Pharmaceutical Bulletin, vol. 22, no. 9, pp. 966-970, 1999.
27. T. Kiho, A. Yamane, J. Hui, S. Usui, and S. Ukai, "Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver, " Biological and Pharmaceutical Bulletin, vol. 19, no. 2, pp. 294-296, 1996.
28. W. C. Kan, H. Y. Wang, C. C. Chienet al., "Effectsof extract from solid-state fermented Cordyceps sinensis on type 2 diabetesmellitus, " Evidence-BasedComplementary andAlternativeMedicine, vol. 2012, Article ID743107, 10 pages, 2012.
29. I. Hong, P. Kang, K. Kim et al., "Fruit body formation on silkworm by Cordycepsmilitaris, " Mycobiology, vol. 38, no. 2, pp. 128-132, 2010.
30. H. Hur, "Chemical ingredients of cordyceps militaris, " Mycobiology, vol. 36, no. 4, pp. 233-235, 2008.
31. Y. Dong, T. Jing, Q. Meng et al., "Studies on the antidiabetic activities of cordyceps militaris extract in diet-streptozotocininduced diabetic sprague-dawley rats, " BioMed Research International, vol. 2014, Article ID 160980, 11 pages, 2014.
32. H.-Y. Wang, W.-C. Kan, T.-J. Cheng, S.-H. Yu, L.-H. Chang, and J.-J. Chuu, "Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice, " Food and Chemical Toxicology, vol. 69, pp. 347-356, 2014.
33. J. R. Zierath and Y. Kawano, "The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle, " Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 17, no. 3, pp. 385-398, 2003.
34. G. Dimitriadis, P. Mitron, V. Lambadiari, E. Maratou, and S. A. Raptis, "Insulin effects in muscle and adipose tissue, " Diabetes Research and Clinical Practice, vol. 93, supplement 1, pp. S52-S59, 2011.
35. K. Schoonjans, B. Staels, and J. Auwerx, "The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation, " Biochimica et Biophysica Acta-Lipids and Lipid Metabolism, vol. 1302, no. 2, pp. 93-109, 1996.
36. T. Sasase, M. G. Pezzolesi, N. Yokoi, T. Yamada, and K. Matsumoto, "Animal models of diabetes andmetabolic disease, " Journal of Diabetes Research, vol. 2013, Article ID 281928, 2 pages, 2013.
37. M. Y. Hui, B.-S. Wang, C. H. Shiow, and P.-D. Duh, "Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage, " Journal of Agricultural and Food Chemistry, vol. 54, no. 8, pp. 3132-3138, 2006.
38. G. Zhang, Y. Huang, Y. Bian, J. H. Wong, T. B. Ng, and H. Wang, "Hypoglycemic activity of the fungi Cordyceps militaris, Cordyceps sinensis, Tricholoma mongolicum, and Omphalia lapidescens in streptozotocin-induced diabetic rats, " Applied Microbiology and Biotechnology, vol. 72, no. 6, pp. 1152-1156, 2006.
39. X. Liu, K. Huang, and J. Zhou, "Composition and antitumor activity of the mycelia and fruiting bodies of Cordyceps militaris, " Journal of Food and Nutrition Research, vol. 2, no. 2, pp. 74-79, 2014.
40. S.-J. Huang, S.-Y. Tsai, Y.-L. Lee, and J.-L. Mau, "Nonvolatile taste components of fruit bodies and mycelia of Cordyceps militaris, " LWT-Food Science and Technology, vol. 39, no. 6, pp. 577-583, 2006.
41. I. P. Hong, P. D. Kang, K. Y. Kim et al., "Fruit body formation on silkworm by Cordyceps militaris, " Mycobiology, vol. 38, no. 2, pp. 128-132, 2010.
42. Y.-J. Ahn, S.-J. Park, S.-G. Lee, S.-C. Shin, and D.-H. Choi, "Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp, " Journal ofAgricultural and Food Chemistry, vol. 48, no. 7, pp. 2744-2748, 2000.
43. K. Nakamura, K. Shinozuka, and N. Yoshikawa, "Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis, " Journal of Pharmacological Sciences, vol. 127, no. 1, pp. 53-56, 2015.
44. M.-H. Jeong, C.-M. Lee, S.-W. Lee et al., "Cordycepinenriched Cordyceps militaris induces immunomodulation and tumor growth delay in mouse-derived breast cancer, " Oncology Reports, vol. 30, no. 4, pp. 1996-2002, 2013.
45. A. M. Sugar and R. P. McCaffrey, "Antifungal activity of 3-deoxyadenosine (cordycepin), " Antimicrobial Agents and Chemotherapy, vol. 42, no. 6, pp. 1424-1427, 1998.
46. V. Y. Kryukov, O. N. Yaroslavtseva, I. M. Dubovskiy, M. V. Tyurin, N. A. Kryukova, and V. V. Glupov, "Insecticidal and immunosuppressive effect of ascomycete Cordyceps militaris on the larvae of the Colorado potato beetle Leptinotarsa decemlineata, " Biology Bulletin, vol. 41, no. 3, pp. 276-283, 2014.
47. S. Shin, S. Lee, J. Kwon et al., "Cordycepin suppresses expression of diabetes regulating genes by inhibition of lipopolysaccharideinduced inflammation in macrophages, " Immune Network, vol. 9, no. 3, pp. 98-105, 2009.
48. R. M. Berne, "The role of adenosine in the regulation of coronary blood flow, " Circulation Research, vol. 47, no. 6, pp. 807-813, 1980.
49. P. Hollander, "Anti-diabetes and anti-obesity medications: effects on weight in people with diabetes, " Diabetes Spectrum, vol. 20, no. 3, pp. 159-165, 2007.
50. P. Poirier, T. D. Giles, G. A. Bray et al., "Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 5, pp. 968-976, 2006.
51. A. R. Saltiel and C. R. Kahn, "Insulin signalling and the regulation of glucose and lipid metabolism, " Nature, vol. 414, no. 6865, pp. 799-806, 2001.
52. F. Karpe, J. R. Dickmann, and K. N. Frayn, "Fatty acids, obesity, and insulin resistance: time for a reevaluation, " Diabetes, vol. 60, no. 10, pp. 2441-2449, 2011.
53. K. M. Panag, N. Kaur, and G. Goyal, "Correlation of insulin resistance by various methods with fasting insulin in obese, " International Journal of Applied and BasicMedical Research, vol. 4, no. 3, supplement 1, pp. S41-S45, 2014.
54. R. Mack, B. Skurnick, Y. Sterling-Jean, M. Pedra-Nobre, and D. Bigg, "Fasting insulin levels as a measure of insulin resistance in American blacks, " Journal of Medicine, vol. 34, no. 1-6, pp. 31-38, 2003.
55. H. B. Li, Y. R. Yang, Z. J. Mo, Y. Ding, and W. Jiang, "Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition, " Brazilian Journal ofMedical and Biological Research, vol. 48, no. 5, pp. 440-446, 2015.
56. D. Zhou, R. S. Strakovsky, X. Zhang, and Y.-X. Pan, "The skeletal muscle wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model, " Obesity, vol. 20, no. 8, pp. 1577-1584, 2012.
57. A. Avogaro, S. V. de Kreutzenberg, and G. P. Fadini, "Oxidative stress and vascular disease in diabetes: Is the dichotomization of insulin signaling still valid" Free Radical Biology andMedicine, vol. 44, no. 6, pp. 1209-1215, 2008.
58. S. Guo, "Molecular basis of insulin resistance: the role of IRS and Foxo1 in the control of diabetes mellitus and its complications, " Drug Discovery Today: Disease Mechanisms, vol. 10, no. 1-2, pp. e27-e33, 2013.
59. S. Fuller, A. J. Richard, D. M. Ribnicky, R. Beyl, R. Mynatt, and J. M. Stephens, "St. John'sWort has metabolically favorable effects on adipocytes in vivo, " Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 862575, 8 pages, 2014.
60. E. Tomás, Y.-S. Lin, Z. Dagher et al., "Hyperglycemia and insulin resistance: possible mechanisms, " Annals of the New York Academy of Sciences, vol. 967, pp. 43-51, 2002.
61. N. M. Leguisamo, A. M. Lehnen, U. F. Machado et al., "GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome, " Cardiovascular Diabetology, vol. 11, article 100, 2012.
62. S.-I. Ikeda, Y. Tamura, S. Kakehi et al., "Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle, " Biochemical and Biophysical Research Communications, vol. 441, no. 1, pp. 36-41, 2013.
63. J. Rung, S. Cauchi, A. Albrechtsen et al., "Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia, " Nature Genetics, vol. 41, no. 10, pp. 1110-1115, 2009.
64. S. M. Schultze, B. A. Hemmings, M. Niessen, and O. Tschopp, "PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis, " Expert Reviews in Molecular Medicine, vol. 14, article e1, 21 pages, 2012.
65. R. S. Garofalo, S. J. Orena, K. Rafidi et al., "Severe diabetes, agedependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB, " Journal of Clinical Investigation, vol. 112, no. 2, pp. 197-208, 2003.
66. S. E. Leney and J. M. Tavaré, "The molecular basis of insulinstimulated glucose uptake: Signalling, trafficking and potential drug targets, " Journal of Endocrinology, vol. 203, no. 1, pp. 1-18, 2009.
67. U. Kintscher and R. E. Law, "PPAR-mediated insulin sensitization: the importance of fat versusmuscle, "TheAmerican Journal of Physiology: Endocrinology andMetabolism, vol. 288, no. 2, pp. E287-E291, 2005.
68. S. Rocchi and J. Auwerx, "Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription, " British Journal of Nutrition, vol. 84, supplement 2, pp. S223-S227, 2000.