Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel

Acta Biomaterialia

Volumn 23, Issue , 2015, Pages 271-281

  Zhang, Li ^a   Shen, Wenjia ^a   Luan, Jiabin ^a   Yang, Dongxiao ^a   Wei, Gang ^a   Yu, Lin ^a   Lu, Weiyue ^a   Ding, Jiandong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Dexamethasone; Intraocular drug delivery; Intravitreal injection; Thermogel; Triblock copolymer

Indexed keywords

BIOCOMPATIBILITY; CONTROLLED DRUG DELIVERY; LACTIC ACID; MIXING; PHYSIOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SOLS; TARGETED DRUG DELIVERY; TEMPERATURE;

DEXAMETHASONES; INJECTABLES; INTRAOCULAR; INTRAOCULAR DRUG DELIVERY; INTRAVITREAL INJECTION; POLY LACTIC ACID-CO GLYCOLIC ACID; POSTERIOR SEGMENT; THERAPEUTIC AGENTS; THERMOGELS; TRIBLOCK-COPOLYMERS;

BLOCK COPOLYMERS;

DEXAMETHASONE; MACROGOL 1000; MACROGOL 1500; MACROGOL DERIVATIVE; POLYGLACTIN; UNCLASSIFIED DRUG; DRUG IMPLANT; GEL; POLY(LACTIDE-CO-GLYCOLIDE)-BLOCK-POLY(ETHYLENE GLYCOL)-BLOCK-POLY(LACTIDE-CO-GLYCOLIDE); POLYESTER;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BODY TEMPERATURE; CONTROLLED STUDY; CORNEA; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; EXPERIMENTAL RABBIT; GEL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF QUANTITATION; LOW TEMPERATURE; MALE; MEAN RESIDENCE TIME; NONHUMAN; PHASE TRANSITION; POLYMERIZATION; PRIORITY JOURNAL; RETINA; RING OPENING; SUSTAINED DRUG RELEASE; THERMOGEL; TRANSITION TEMPERATURE; VISCOSITY; ADMINISTRATION AND DOSAGE; ANIMAL; BIODEGRADABLE IMPLANT; CHEMISTRY; DIFFUSION; DRUG IMPLANT; INTRAVITREAL DRUG ADMINISTRATION; PROCEDURES; RABBIT; SYNTHESIS; TEMPERATURE; TISSUE DISTRIBUTION; VITREOUS BODY;

ORYCTOLAGUS CUNICULUS;

ABSORBABLE IMPLANTS; ANIMALS; DEXAMETHASONE; DIFFUSION; DRUG IMPLANTS; GELS; INTRAVITREAL INJECTIONS; MALE; POLYESTERS; POLYETHYLENE GLYCOLS; RABBITS; TEMPERATURE; TISSUE DISTRIBUTION; VITREOUS BODY;

EID: 84938213939     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.05.005     Document Type: Article

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