Injectable and biodegradable poly(organophosphazene) hydrogel as a delivery system of docetaxel for cancer treatment

Journal of Drug Targeting

Volumn 21, Issue 6, 2013, Pages 564-573

  Cho, Jung Kyo ^a,b   Hong, Ji Min ^a   Han, Taesu ^c   Yang, Han Kwang ^c   Song, Soo Chang ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Biodegradable polymers; Controlled drug delivery; Docetaxel; Gastric cancer; Hydrogels; Injectable; Poly(organophosphazene); Sustained release system; Thermosensitive

Indexed keywords

DOCETAXEL; MACROGOL; POLY(ORGANOPHOSPHAZENE); POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; FEMALE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; STOMACH CANCER; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYDROGEL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MATERIALS TESTING; MICE; MICE, INBRED BALB C; MICE, NUDE; ORGANOPHOSPHORUS COMPOUNDS; POLYETHYLENE GLYCOLS; POLYMERS; SOLUBILITY; STOMACH NEOPLASMS; TAXOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84879772205     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2013.776055     Document Type: Article

References (30)

1. Montero A, Fossella F, Hortobagyi G, Valero V. Docetaxel for treatment of solid tumours: a systematic review of clinical data. Lancet Oncol 2005;6:229-39.
2. Bissery MC, Guenard D, Gueritte-Voegelein F, Lavelle F. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Res 1991;51:4845-52.
3. Dosio F, Stella B, Arpicco S, Cattel L. Macromolecules as taxane delivery systems. Expert Opin Drug Deliv 2011;8:33-55.
4. Engels FK, Mathot RA, Verweij J. Alternative drug formulations of docetaxel: a review. Anticancer Drugs 2007;18:95-103.
5. Hennenfent KL, Govindan R. Novel formulations of taxanes: a review. Old wine in a new bottle? Ann Oncol: Official J Eur Soc Med Oncol/ESMO 2006;17:735-49.
6. Gastaldi D, Zonari D, Dosio F. Targeted taxane delivery systems: recent advances. Drug Deliv Lett 2011;1:105-17.
7. Park MH, Joo MK, Choi BG, Jeong B. Biodegradable thermogels. Acc Chem Res 2012;45:424-33.
8. Li Y, Rodrigues J, Tomas H. Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chem Soc Rev 2012;41:2193-221.
9. Cho JK, Hong KY, Park JW, et al. Injectable delivery system of 2-methoxyestradiol for breast cancer therapy using biodegradable thermosensitive poly(organophosphazene) hydrogel. J Drug Target 2011;19:270-80.
10. Al-Abd AM, Hong KY, Song SC, Kuh HJ. Pharmacokinetics of doxorubicin after intratumoral injection using a thermosensitive hydrogel in tumor-bearing mice. J Control Release: Official J Control Release Soc 2010;142:101-7.
11. Lee SM, Chun CJ, Heo JY, Song SC. Injectable and thermosensitive poly(organophosphazene) hydrogels for a 5-fluorouracil delivery. J Appl Polym Sci 2009;113:3831-9.
12. Chun C, Lee SM, Kim SY, et al. Thermosensitive poly(organophosphazene)- paclitaxel conjugate gels for antitumor applications. Biomaterials 2009;30:2349-60.
13. Chun C, Lee SM, Kim CW, et al. Doxorubicin-polyphosphazene conjugate hydrogels for locally controlled delivery of cancer therapeutics. Biomaterials 2009;30:4752-62.
14. Kang GD, Cheon SH, Song SC. Controlled release of doxorubicin from thermosensitive poly(organophosphazene) hydrogels. Int J Pharmaceu 2006;319:29-36.
15. Cho JK, Park JW, Song SC. Injectable and biodegradable poly(organophosphazene) gel containing silibinin: its physicochemical properties and anticancer activity. J Pharm Sci 2012;101: 2382-91.
16. Gao Y, Ren F, Ding B, et al. A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel. J Drug Target 2011;19: 516-27.
17. Crommen J, Vandorpe J, Schacht E. Degradable polyphosphazenes for biomedical applications. J Control Release 1993;24: 167-80.
18. Sohn YS, Cho YH, Baek H, Jung OS. Synthesis and properties of low-molecular-weight polyphosphazenes. Macromolecules 1995; 28:7566-8.
19. Bromberg L, Temchenko M. Self-assembly in aqueous solutions of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-poly(vinyl alcohol). Langmuir 1999;15:8633-9.
20. Yu J, Lee HJ, Hur K, et al. The antitumor effect of a thermosensitive polymeric hydrogel containing paclitaxel in a peritoneal carcinomatosis model. Invest New Drug 2012;30:1-7.
21. Markovsky E, Baabur-Cohen H, Eldar-Boock A, et al. Administration, distribution, metabolism and elimination of polymer therapeutics. J Control Release: Official J Control Release Soc 2012;161:446-60.
22. Imai Y. Interactions between polymers and biosystems. In: Tsuruta T, Hayashi T, Kataoka K, et al., eds. Biomedical applications of polymeric materials. 1st ed. Boca Raton (FL): CRC Press, Inc.; 1993:54-6.
23. Cho JK, Lee SM, Kim CW, Song SC. Synthesis and characterization of biodegradable thermosensitive neutral and acidic poly(organophosphazene) gels bearing carboxylic acid group. J Polym Res 2011;18:701-13.
24. Ahn S, Monge EC, Song SC. Ion and pH effect on the lower critical solution temperature phase behavior in neutral and acidic poly(organophosphazene) counterparts. Langmuir 2009;25: 2407-18.
25. Dumortier G, Grossiord JL, Agnely F, Chaumeil JC. A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharmaceut Res 2006;23:2709-28.
26. Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 2001;48:139-57.
27. Lin CC, Metters AT. Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliv Rev 2006;58:1379-408.
28. Nie S, Hsiao WL, Pan W, Yang Z. Thermoreversible Pluronic F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies. Int J nanomedicine 2011;6:151-66.
29. NC Institute. Drugs approved for stomach (gastric) cancer; 2011. Available from: http://www.cancer.gov/cancertopics/druginfo/stomachcancer [Online], 2012; http://www.cancer.gov/cancertopics/druginfo/stomachcancer
30. Lee SB, Song SC, Jin JI, Sohn YS. A new class of biodegradable thermosensitive polymers. 2. Hydrolytic properties and salt effect on the lower critical solution temperature of poly(organophosphazenes) with methoxypoly(ethylene glycol) and amino acid esters as side groups. Macromolecules 1999;32:7820-7.