Adjustable degradation and drug release of a thermosensitive hydrogel based on a pendant cyclic ether modified poly(e-caprolactone) and poly(ethylene glycol)co-polymer

Acta Biomaterialia

Volumn 8, Issue 11, 2012, Pages 3963-3973

  Wang, Weiwei ^a   Deng, Liandong ^a   Liu, Shasha ^a   Li, Xu ^b   Zhao, Xiumei ^b   Hu, Renjie ^b   Zhang, Jianhua ^a   Han, Haijie ^a   Dong, Anjie ^a  

^a TIANJIN UNIVERSITY   (China)

^b Tianjin Institute of Medical and Pharmaceutical Science   (China)

Author keywords

Amphiphilicco polymer; Hydrophilic modification; Local drug delivery system; Paclitaxel; Thermosensitive hydrogel

Indexed keywords

CONTROLLED DRUG DELIVERY; ETHERS; ETHYLENE GLYCOL; HYDROPHILICITY; HYDROPHOBICITY; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYOLS; TARGETED DRUG DELIVERY;

AMPHIPHILICCO-POLYMER; CYCLIC ETHER; DRUG RELEASE; DRUG-DELIVERY SYSTEMS; HYDROPHILIC MODIFICATION; LOCAL DRUG DELIVERY; LOCAL DRUG DELIVERY SYSTEM; PACLITAXEL; POLY(E-CAPROLACTONE); THERMO-SENSITIVE HYDROGEL;

HYDROGELS;

COPOLYMER; ETHER DERIVATIVE; ETHYLENE VINYL ACETATE COPOLYMER; MACROGOL; PACLITAXEL; POLY(EPSILON CAPROLACTONE CO1,4,8 TRIOXA[4.6]SPIRO 9 UNDECANONE) POLY(ETHYLENE GLYCOL) POLY(EPSILON CAPROLACTONE CO 1,4,8 TRIOXA[4.6]SPIRO 9 UNDECANONE) COPOLYMER; POLYCAPROLACTONE; UNCLASSIFIED DRUG; WATER; MACROGOL DERIVATIVE; NANOPARTICLE; POLYESTER; SPIRO COMPOUND;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BODY TEMPERATURE; CHEMICAL PARAMETERS; CHEMICAL PHENOMENA; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CRYSTALLINITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ENVIRONMENTAL TEMPERATURE; HISTOPATHOLOGY; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; RETENTION TIME; ANIMAL; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECT; FREEZE DRYING; MATERIALS TESTING; MOLECULAR WEIGHT; PARTICLE SIZE; SOLUBILITY; SOLUTION AND SOLUBILITY; TEMPERATURE; ULTRASTRUCTURE; X RAY DIFFRACTION;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; ETHERS, CYCLIC; FREEZE DRYING; HYDROGEL; MATERIALS TESTING; MICE; MOLECULAR WEIGHT; NANOPARTICLES; PACLITAXEL; PARTICLE SIZE; PHASE TRANSITION; POLYESTERS; POLYETHYLENE GLYCOLS; SOLUBILITY; SOLUTIONS; SPIRO COMPOUNDS; TEMPERATURE; X-RAY DIFFRACTION;

EID: 84873964266     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.07.021     Document Type: Article

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