Effects of polyvinylpyrrolidone both as a binder and pore-former on the release of sparingly water-soluble topiramate from ethylcellulose coated pellets

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 187-196

  Yang, Meiyan ^a   Xie, Si ^a,b   Li, Qiu ^c   Wang, Yuli ^a   Chang, Xinyi ^d   Shan, Li ^a   Sun, Lei ^d   Huang, Xiaoli ^a,b   Gao, Chunsheng ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF TECHNOLOGY   (China)

^d HENAN UNIVERSITY   (China)

Author keywords

Binder; Drug release mechanism; Pore former; PVP K30; Sparingly water soluble drug; Topiramate

Indexed keywords

CRYSTALLIN; ETHYL CELLULOSE; POVIDONE; TOPIRAMATE; WATER; ANTICONVULSIVE AGENT; CELLULOSE; DRUG CARRIER; DRUG IMPLANT; FRUCTOSE;

ARTICLE; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MANUFACTURE; DRUG PELLET; DRUG RELEASE; DRUG SOLUBILITY; FILM; OSMOLALITY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; WATER PERMEABILITY; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMICAL PHENOMENA; CHEMISTRY; CRYSTALLIZATION; DRUG IMPLANT; KINETICS; MEDICINAL CHEMISTRY; OSMOLARITY; PHARMACEUTICS; POROSITY; PROCEDURES; SOLUBILITY; SURFACE PROPERTY;

ANTICONVULSANTS; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG IMPLANTS; FRUCTOSE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MODELS, CHEMICAL; OSMOLAR CONCENTRATION; POROSITY; POVIDONE; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 84898597854     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.021     Document Type: Article

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