A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of rna-binding proteins

Combinatorial Chemistry and High Throughput Screening

Volumn 17, Issue 7, 2014, Pages 596-609

  Minuesa, Gerard ^a,b   Antczak, Christophe ^a,c   Shum, David ^a   Radu, Constantin ^a   Bhinder, Bhavneet ^a   Li, Yueming ^a   Djaballah, Hakim ^a   Kharas, Michael G ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Center for Cell Engineering   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Cancer; Fluorescence polarization; HTS; MUSASHI; RNA binding protein; Small molecule inhibitors

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; PROTEIN INHIBITOR; RNA BINDING PROTEIN; RNA BINDING PROTEIN MUSASHI; RNA BINDING PROTEIN MUSASHI 1; RNA BINDING PROTEIN MUSASHI 2; UNCLASSIFIED DRUG; MOLECULAR LIBRARY; MSI1 PROTEIN, HUMAN; MSI2 PROTEIN, HUMAN; NERVE PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; FLUORESCENCE; FLUORESCENCE POLARIZATION; GEL MOBILITY SHIFT ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; IN VITRO STUDY; MICROTITER PLATE ASSAY; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN STABILITY; RNA BINDING; ANTAGONISTS AND INHIBITORS; CHEMISTRY; METABOLISM; PHARMACOLOGY; PROCEDURES;

DRUG EVALUATION, PRECLINICAL; FLUORESCENCE POLARIZATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NERVE TISSUE PROTEINS; PROTEIN BINDING; RNA-BINDING PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84906242610     PISSN: 13862073     EISSN: 18755402     Source Type: Journal    
DOI: 10.2174/1386207317666140609122714     Document Type: Article

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