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Volumn 1853, Issue 10, 2015, Pages 2453-2463

HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model

Author keywords

C Met; Epithelial mesenchymal transition; Invasion; Liver progenitor cell; Migration; PI3K

Indexed keywords

F ACTIN; MATRIX METALLOPROTEINASE; OCCLUDIN; OCCLUDIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ZO1; RAC1 PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; UVOMORULIN; ACTIN; CADHERIN; HGF PROTEIN, MOUSE; NEUROPEPTIDE; OCLN PROTEIN, MOUSE; RAC1 PROTEIN, MOUSE; TJP1 PROTEIN, MOUSE;

EID: 84938153533     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2015.05.017     Document Type: Article
Times cited : (38)

References (59)
  • 1
    • 67650957717 scopus 로고    scopus 로고
    • Stems cells and liver regeneration
    • Duncan A.W., Dorrell C., Grompe M. Stems cells and liver regeneration. Gastroenterology 2009, 137(2):466-481. 10.1053/j.gastro.2009.05.044.
    • (2009) Gastroenterology , vol.137 , Issue.2 , pp. 466-481
    • Duncan, A.W.1    Dorrell, C.2    Grompe, M.3
  • 3
    • 84879384652 scopus 로고    scopus 로고
    • Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation
    • Kuramitsu K., Sverdlov D.Y., Liu S.B., Csizmadia E., Burkly L., Schuppan D., Hanto D.W., Otterbein L.E., Popov Y. Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am. J. Pathol. 2013, 183(1):182-194. 10.1016/j.ajpath.2013.03.018.
    • (2013) Am. J. Pathol. , vol.183 , Issue.1 , pp. 182-194
    • Kuramitsu, K.1    Sverdlov, D.Y.2    Liu, S.B.3    Csizmadia, E.4    Burkly, L.5    Schuppan, D.6    Hanto, D.W.7    Otterbein, L.E.8    Popov, Y.9
  • 4
    • 67650469849 scopus 로고    scopus 로고
    • Liver cancer stem cells: implications for a new therapeutic target
    • Lee T.K., Castilho A., Ma S., Ng I.O. Liver cancer stem cells: implications for a new therapeutic target. Liver Int. 2009, 29(7):955-965. 10.1111/j.1478-3231.2009.02040.x.
    • (2009) Liver Int. , vol.29 , Issue.7 , pp. 955-965
    • Lee, T.K.1    Castilho, A.2    Ma, S.3    Ng, I.O.4
  • 5
    • 44249105872 scopus 로고    scopus 로고
    • Signaling networks in hepatic oval cell activation
    • Erker L., Grompe M. Signaling networks in hepatic oval cell activation. Stem Cell Res. 2007, 1(2):90-102. 10.1016/j.scr.2008.01.002.
    • (2007) Stem Cell Res. , vol.1 , Issue.2 , pp. 90-102
    • Erker, L.1    Grompe, M.2
  • 6
    • 78649397555 scopus 로고    scopus 로고
    • Growth factor- and cytokine-driven pathways governing liver stemness and differentiation
    • Sánchez A., Fabregat I. Growth factor- and cytokine-driven pathways governing liver stemness and differentiation. World J. Gastroenterol. 2010, 16(41):5148-5161. 10.3748/wjg.v16.i41.5148.
    • (2010) World J. Gastroenterol. , vol.16 , Issue.41 , pp. 5148-5161
    • Sánchez, A.1    Fabregat, I.2
  • 8
    • 1842428601 scopus 로고    scopus 로고
    • Hepatocyte growth factor/c-Met signaling pathway is required for efficient liver regeneration and repair
    • Huh C.G., Factor V.M., Sánchez A., Uchida K., Conner E.A., Thorgeirsson S.S. Hepatocyte growth factor/c-Met signaling pathway is required for efficient liver regeneration and repair. Proc. Natl. Acad. Sci. U. S. A. 2004, 101(13):4477-4482. 10.1073/pnas.0306068101.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , Issue.13 , pp. 4477-4482
    • Huh, C.G.1    Factor, V.M.2    Sánchez, A.3    Uchida, K.4    Conner, E.A.5    Thorgeirsson, S.S.6
  • 10
    • 4544334443 scopus 로고    scopus 로고
    • Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration
    • Phaneuf D., Moscioni A.D., LeClair C., Raper S.E., Wilson J.M. Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration. DNA Cell Biol. 2004, 23(9):592-603. 10.1089/dna.2004.23.592.
    • (2004) DNA Cell Biol. , vol.23 , Issue.9 , pp. 592-603
    • Phaneuf, D.1    Moscioni, A.D.2    LeClair, C.3    Raper, S.E.4    Wilson, J.M.5
  • 11
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: principles and functions in development, organ regeneration and cancer
    • Trusolino L., Bertotti A., Comoglio P.M. MET signalling: principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2010, 11(12):834-848. 10.1038/nrm3012.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , Issue.12 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 12
    • 78650770246 scopus 로고    scopus 로고
    • Hepatocyte growth factor twenty years on: much more than a growth factor
    • Nakamura T., Sakai K., Nakamura T., Matsumoto K. Hepatocyte growth factor twenty years on: much more than a growth factor. J. Gastroenterol. Hepatol. 2011, 26(Suppl. 1):188-202. 10.1111/j.1440-1746.2010.06549.x.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 188-202
    • Nakamura, T.1    Sakai, K.2    Nakamura, T.3    Matsumoto, K.4
  • 13
    • 0036217866 scopus 로고    scopus 로고
    • Invasive growth: from development to metastasis
    • Comoglio P.M., Trusolino L. Invasive growth: from development to metastasis. J. Clin. Invest. 2002, 109(7):857-862. 10.1172/JCI15392.
    • (2002) J. Clin. Invest. , vol.109 , Issue.7 , pp. 857-862
    • Comoglio, P.M.1    Trusolino, L.2
  • 16
    • 84859153211 scopus 로고    scopus 로고
    • Hepatocyte growth factor/c-Met signaling is required for stem-cell-mediated liver regeneration in mice
    • Ishikawa T., Factor V.M., Marquardt J.U., Raggi C., Seo D., Kitade M., Conner E.A., Thorgeirsson S.S. Hepatocyte growth factor/c-Met signaling is required for stem-cell-mediated liver regeneration in mice. Hepatology 2012, 55(4):1215-1226. 10.1002/hep.24796.
    • (2012) Hepatology , vol.55 , Issue.4 , pp. 1215-1226
    • Ishikawa, T.1    Factor, V.M.2    Marquardt, J.U.3    Raggi, C.4    Seo, D.5    Kitade, M.6    Conner, E.A.7    Thorgeirsson, S.S.8
  • 17
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M., Gherardi E., Perryman M., Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 1987, 327(6119):239-242. 10.1038/327239a0.
    • (1987) Nature , vol.327 , Issue.6119 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 18
    • 0031594327 scopus 로고    scopus 로고
    • Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines
    • Kamiyama T., Une Y., Uchino J., Hamada J. Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines. Int. J. Oncol. 1998, 12(3):655-659. 10.3892/ijo.12.3.655.
    • (1998) Int. J. Oncol. , vol.12 , Issue.3 , pp. 655-659
    • Kamiyama, T.1    Une, Y.2    Uchino, J.3    Hamada, J.4
  • 20
    • 0242537137 scopus 로고    scopus 로고
    • Transforming growth factor-beta (TGF-beta) and EGF promote cord-like structures that indicate terminal differentiation of fetal hepatocytes in primary culture
    • Sánchez A., Pagan R., Alvarez A.M., Roncero C., Vilaró S., Benito M., Fabregat I. Transforming growth factor-beta (TGF-beta) and EGF promote cord-like structures that indicate terminal differentiation of fetal hepatocytes in primary culture. Exp. Cell Res. 1998, 242(1):27-37. 10.1006/excr.1998.4088.
    • (1998) Exp. Cell Res. , vol.242 , Issue.1 , pp. 27-37
    • Sánchez, A.1    Pagan, R.2    Alvarez, A.M.3    Roncero, C.4    Vilaró, S.5    Benito, M.6    Fabregat, I.7
  • 21
    • 34547091942 scopus 로고    scopus 로고
    • P38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum
    • Zuluaga S., Gutiérrez-Uzquiza A., Bragado P., Alvarez-Barrientos A., Benito M., Nebreda A.R., Porras A. p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum. FEBS Lett. 2007, 581(20):3819-3825. 10.1016/j.febslet.2007.06.078.
    • (2007) FEBS Lett. , vol.581 , Issue.20 , pp. 3819-3825
    • Zuluaga, S.1    Gutiérrez-Uzquiza, A.2    Bragado, P.3    Alvarez-Barrientos, A.4    Benito, M.5    Nebreda, A.R.6    Porras, A.7
  • 22
    • 2942564379 scopus 로고    scopus 로고
    • The actin cytoskeleton in normal and pathological cell motility
    • Lambrechts A., Van Troys M., Ampe C. The actin cytoskeleton in normal and pathological cell motility. Int. J. Biochem. Cell Biol. 2004, 36(10):1890-1909. 10.1016/j.biocel.2004.01.024.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , Issue.10 , pp. 1890-1909
    • Lambrechts, A.1    Van Troys, M.2    Ampe, C.3
  • 23
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley A.J., Paterson H.F., Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 1992, 70(3):401-410. 10.1016/0092-8674(92)90164-8.
    • (1992) Cell , vol.70 , Issue.3 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Hall, A.3
  • 25
    • 33747625686 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
    • Grotegut S., von Schweinitz D., Christofori G., Lehembre F. Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. EMBO J. 2006, 25(15):3534-3545. 10.1038/sj.emboj.7601213.
    • (2006) EMBO J. , vol.25 , Issue.15 , pp. 3534-3545
    • Grotegut, S.1    von Schweinitz, D.2    Christofori, G.3    Lehembre, F.4
  • 26
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • Lamouille S., Xu J., Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 2014, 15(3):178-196. 10.1038/nrm3758.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , Issue.3 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 27
    • 2642559697 scopus 로고    scopus 로고
    • Cell motility: Golgi signalling shapes up and ship out
    • Mellor H. Cell motility: Golgi signalling shapes up and ship out. Curr. Biol. 2004, 14(11):R434-R435.
    • (2004) Curr. Biol. , vol.14 , Issue.11 , pp. R434-R435
    • Mellor, H.1
  • 28
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • Kessenbrock Kai, Plaks Vicki, Werb Zena Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010, 141(1):52-67. 10.1016/j.cell.2010.03.015.
    • (2010) Cell , vol.141 , Issue.1 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 29
    • 0032578775 scopus 로고    scopus 로고
    • Membrane type 1-matrix metalloproteinaase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in Madin-Darby canine kidney epithelial cells
    • Kadono Y., Shibahara K., Namiki M., Watanabe Y., Seiki M., Sato H. Membrane type 1-matrix metalloproteinaase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in Madin-Darby canine kidney epithelial cells. Biochem. Biophys. Res. Commun. 1998, 251(3):681-687. 10.1006/bbrc.1998.9531.
    • (1998) Biochem. Biophys. Res. Commun. , vol.251 , Issue.3 , pp. 681-687
    • Kadono, Y.1    Shibahara, K.2    Namiki, M.3    Watanabe, Y.4    Seiki, M.5    Sato, H.6
  • 30
    • 0033222965 scopus 로고    scopus 로고
    • Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase
    • Murakami K., Sakukawa R., Ikeda T., Matsuura T., Hasumura S., Nagamori S., Yamada Y., Saiki I. Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase. Neoplasia 1999, 1(5):424-430.
    • (1999) Neoplasia , vol.1 , Issue.5 , pp. 424-430
    • Murakami, K.1    Sakukawa, R.2    Ikeda, T.3    Matsuura, T.4    Hasumura, S.5    Nagamori, S.6    Yamada, Y.7    Saiki, I.8
  • 31
    • 0037050023 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase type-3 in hepatocyte growth factor-induced invasion of human hepatocellular carcinoma cells
    • Monvoisin A., Bisson C., Si-Tayeb K., Balabaud C., Desmoulière A., Rosenbaum J. Involvement of matrix metalloproteinase type-3 in hepatocyte growth factor-induced invasion of human hepatocellular carcinoma cells. Int. J. Cancer 2002, 97(2):157-162. 10.1002/ijc.1595.
    • (2002) Int. J. Cancer , vol.97 , Issue.2 , pp. 157-162
    • Monvoisin, A.1    Bisson, C.2    Si-Tayeb, K.3    Balabaud, C.4    Desmoulière, A.5    Rosenbaum, J.6
  • 32
    • 77049113770 scopus 로고    scopus 로고
    • The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity
    • Brew K., Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim. Biophys. Acta 2010, 1803(1):55-71. 10.1016/j.bbamcr.2010.01.003.
    • (2010) Biochim. Biophys. Acta , vol.1803 , Issue.1 , pp. 55-71
    • Brew, K.1    Nagase, H.2
  • 33
    • 0037302117 scopus 로고    scopus 로고
    • HGF/SF-Met signaling in the control of branching morphogenesis and invasion
    • Zhang Y.W., Vande Woude G.F. HGF/SF-Met signaling in the control of branching morphogenesis and invasion. J. Cell. Biochem. 2003, 88(2):408-417. 10.1002/jcb.10358.
    • (2003) J. Cell. Biochem. , vol.88 , Issue.2 , pp. 408-417
    • Zhang, Y.W.1    Vande Woude, G.F.2
  • 34
    • 0027256029 scopus 로고
    • Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells
    • Johnson M., Koukoulis G., Matsumoto K., Nakamura T., Iyer A. Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells. Hepatology 1993, 17(6):1052-1061.
    • (1993) Hepatology , vol.17 , Issue.6 , pp. 1052-1061
    • Johnson, M.1    Koukoulis, G.2    Matsumoto, K.3    Nakamura, T.4    Iyer, A.5
  • 35
    • 0027327060 scopus 로고
    • Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen gels
    • Michalopoulos G.K., Bowen W., Nussler A.K., Becich M.J., Howard T.A. Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen gels. J. Cell. Physiol. 1993, 156(3):443-452.
    • (1993) J. Cell. Physiol. , vol.156 , Issue.3 , pp. 443-452
    • Michalopoulos, G.K.1    Bowen, W.2    Nussler, A.K.3    Becich, M.J.4    Howard, T.A.5
  • 36
    • 0036636095 scopus 로고    scopus 로고
    • Opinion: building epithelial architecture: insights from three-dimensional culture models
    • O'Brien L.E., Zegers M.M., Mostov K.E. Opinion: building epithelial architecture: insights from three-dimensional culture models. Nat. Rev. Mol. Cell Biol. 2002, 3:531-537. 10.1038/nrm859.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 531-537
    • O'Brien, L.E.1    Zegers, M.M.2    Mostov, K.E.3
  • 37
    • 77956635530 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion
    • Ding W., You H., Dang H., LeBlanc F., Galicia V., Lu S.C., Stiles B., Rountree C.B. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology 2010, 52(3):945-953. 10.1002/hep.23748.
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 945-953
    • Ding, W.1    You, H.2    Dang, H.3    LeBlanc, F.4    Galicia, V.5    Lu, S.C.6    Stiles, B.7    Rountree, C.B.8
  • 38
    • 1442300805 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity
    • Pollack A.L., Apodaca G., Mostov K.E. Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity. Am. J. Physiol. Cell Physiol. 2004, 286(3):C482-C494. 10.1152/ajpcell.00377.2003.
    • (2004) Am. J. Physiol. Cell Physiol. , vol.286 , Issue.3 , pp. C482-C494
    • Pollack, A.L.1    Apodaca, G.2    Mostov, K.E.3
  • 39
    • 0037328574 scopus 로고    scopus 로고
    • Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures
    • Yu W., O'Brien L.E., Wang F., Bourne H., Mostov K.E., Zegers M.M. Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol. Biol. Cell 2003, 14(2):748-763. 10.1091/mbc.E02-06-0350.
    • (2003) Mol. Biol. Cell , vol.14 , Issue.2 , pp. 748-763
    • Yu, W.1    O'Brien, L.E.2    Wang, F.3    Bourne, H.4    Mostov, K.E.5    Zegers, M.M.6
  • 40
    • 67649528138 scopus 로고    scopus 로고
    • Collective cell migration in morphogenesis, regeneration and cancer
    • Friedl P., Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2009, 10(7):445-457. 10.1038/nrm2720.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , Issue.7 , pp. 445-457
    • Friedl, P.1    Gilmour, D.2
  • 41
    • 34547569807 scopus 로고    scopus 로고
    • Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    • Wolf K., Wu Y.I., Liu Y., Geiger J., Tam E., Overall C., Stack M.S., Friedl P. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat. Cell Biol. 2007, 9(8):893-904. 10.1038/ncb1616.
    • (2007) Nat. Cell Biol. , vol.9 , Issue.8 , pp. 893-904
    • Wolf, K.1    Wu, Y.I.2    Liu, Y.3    Geiger, J.4    Tam, E.5    Overall, C.6    Stack, M.S.7    Friedl, P.8
  • 42
    • 33748920475 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 is an important factor in hepatic regeneration after partial hepatectomy in mice
    • Olle E.W., Ren X., McClintock S.D., Warner R.L., Deogracias M.P., Johnson K.J., Colletti L.M. Matrix metalloproteinase-9 is an important factor in hepatic regeneration after partial hepatectomy in mice. Hepatology 2006, 44(3):540-549. 10.1002/hep.21314.
    • (2006) Hepatology , vol.44 , Issue.3 , pp. 540-549
    • Olle, E.W.1    Ren, X.2    McClintock, S.D.3    Warner, R.L.4    Deogracias, M.P.5    Johnson, K.J.6    Colletti, L.M.7
  • 45
    • 0028850053 scopus 로고
    • Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase
    • Royal I., Park M. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase. J. Biol. Chem. 1995, 270(46):27780-27787. 10.1074/jbc.270.46.27780.
    • (1995) J. Biol. Chem. , vol.270 , Issue.46 , pp. 27780-27787
    • Royal, I.1    Park, M.2
  • 46
    • 0037821639 scopus 로고    scopus 로고
    • P38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades
    • Sharma G.D., He J., Bazan H.E. p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. J. Biol. Chem. 2003, 278(24):21989-21997. 10.1074/jbc.M302650200.
    • (2003) J. Biol. Chem. , vol.278 , Issue.24 , pp. 21989-21997
    • Sharma, G.D.1    He, J.2    Bazan, H.E.3
  • 47
    • 33646197380 scopus 로고    scopus 로고
    • Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for Met-triggered cortical neuron migration
    • Segarra J., Balenci L., Drenth T., Maina F., Lamballe F. Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for Met-triggered cortical neuron migration. J. Biol. Chem. 2006, 281(8):4771-4778. 10.1074/jbc.M508298200.
    • (2006) J. Biol. Chem. , vol.281 , Issue.8 , pp. 4771-4778
    • Segarra, J.1    Balenci, L.2    Drenth, T.3    Maina, F.4    Lamballe, F.5
  • 48
    • 34447335316 scopus 로고    scopus 로고
    • Osteoblasts promote migration and invasion of myeloma cells through upregulation of matrix metalloproteinases, urokinase plasminogen activator, hepatocyte growth factor and activation of p38 MAPK
    • Hecht M., Heider U., Kaiser M., von Metzler I., Sterz J., Sezer O. Osteoblasts promote migration and invasion of myeloma cells through upregulation of matrix metalloproteinases, urokinase plasminogen activator, hepatocyte growth factor and activation of p38 MAPK. Br. J. Haematol. 2007, 138(4):446-458. 10.1111/j.1365-2141.2007.06665.x.
    • (2007) Br. J. Haematol. , vol.138 , Issue.4 , pp. 446-458
    • Hecht, M.1    Heider, U.2    Kaiser, M.3    von Metzler, I.4    Sterz, J.5    Sezer, O.6
  • 49
    • 26444466080 scopus 로고    scopus 로고
    • Integrin-dependent actomyosin contraction regulates epithelial cell scattering
    • de Rooij J., Kerstens A., Danuser G., Schwartz M.A., Waterman-Storer C.M. Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J. Cell Biol. 2005, 171(1):153-164. 10.1083/jcb.200506152.
    • (2005) J. Cell Biol. , vol.171 , Issue.1 , pp. 153-164
    • de Rooij, J.1    Kerstens, A.2    Danuser, G.3    Schwartz, M.A.4    Waterman-Storer, C.M.5
  • 50
    • 3042730951 scopus 로고    scopus 로고
    • Control of actin dynamics by p38 MAP kinase-Hsp27 distribution in the lamellipodium of smooth muscle cells
    • Pichon S., Bryckaert M., Berrou E. Control of actin dynamics by p38 MAP kinase-Hsp27 distribution in the lamellipodium of smooth muscle cells. J. Cell Sci. 2004, 117(Pt 12):2569-2577. 10.1242/jcs.01110.
    • (2004) J. Cell Sci. , vol.117 , pp. 2569-2577
    • Pichon, S.1    Bryckaert, M.2    Berrou, E.3
  • 51
    • 34248592575 scopus 로고    scopus 로고
    • Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway
    • Jun
    • Ito S., Kimura K., Haneda M., Ishida Y., Sawada M., Isobe K. Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway. Exp. Gerontol. Jun 2007, 42(6):532-537. 10.1016/j.exger.2006.11.012.
    • (2007) Exp. Gerontol. , vol.42 , Issue.6 , pp. 532-537
    • Ito, S.1    Kimura, K.2    Haneda, M.3    Ishida, Y.4    Sawada, M.5    Isobe, K.6
  • 52
    • 42249109021 scopus 로고    scopus 로고
    • Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells
    • Apr 17
    • Uttamsingh S., Bao X., Nguyen K.T., Bhanot M., Gong J., Chan J.L., Liu F., Chu T.T., Wang L.H. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene Apr 17 2008, 27(18):2626-2634. 10.1038/sj.onc.1210915.
    • (2008) Oncogene , vol.27 , Issue.18 , pp. 2626-2634
    • Uttamsingh, S.1    Bao, X.2    Nguyen, K.T.3    Bhanot, M.4    Gong, J.5    Chan, J.L.6    Liu, F.7    Chu, T.T.8    Wang, L.H.9
  • 53
    • 76549130383 scopus 로고    scopus 로고
    • Koul HK.p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity
    • Jan 15
    • Kumar B., Koul S., Petersen J., Khandrika L., Hwa J.S., Meacham R.B., Wilson S. Koul HK.p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Cancer Res. Jan 15 2010, 70(2):832-841. 10.1158/0008-5472.CAN-09-2918.
    • (2010) Cancer Res. , vol.70 , Issue.2 , pp. 832-841
    • Kumar, B.1    Koul, S.2    Petersen, J.3    Khandrika, L.4    Hwa, J.S.5    Meacham, R.B.6    Wilson, S.7
  • 54
    • 77950652973 scopus 로고    scopus 로고
    • Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes
    • Rosengren S., Corr M., Boyle D.L. Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes. Arthritis Res. Ther. 2010, 12(2):R65. 10.1186/ar2981.
    • (2010) Arthritis Res. Ther. , vol.12 , Issue.2 , pp. R65
    • Rosengren, S.1    Corr, M.2    Boyle, D.L.3
  • 56
    • 84867337357 scopus 로고    scopus 로고
    • Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons
    • Oct
    • Johnson C., Chun-Jen Lin C., Stern M. Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons. Genes Brain Behav. Oct 2012, 11(7):848-858. 10.1111/j.1601-183X.2012.00822.x.
    • (2012) Genes Brain Behav. , vol.11 , Issue.7 , pp. 848-858
    • Johnson, C.1    Chun-Jen Lin, C.2    Stern, M.3
  • 57
    • 0002751520 scopus 로고    scopus 로고
    • Ras/Rac-dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress
    • Li C., Hu Y., Sturm G., Wick G., Xu Q. Ras/Rac-dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress. Arterioscler. Thromb. Vasc. Biol. 2000, 20(3):E1-E9. 10.1161/01.ATV.20.3.e1.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , Issue.3 , pp. E1-E9
    • Li, C.1    Hu, Y.2    Sturm, G.3    Wick, G.4    Xu, Q.5


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