Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 30, 2015, Pages E4036-E4045

  Sekiyama, Naotaka ^a,b   Arthanari, Haribabu ^a   Papadopoulos, Evangelos ^a   Rodriguez Mias, Ricard A ^a,c   Wagner, Gerhard ^a   Léger Abraham, Mélissa ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Phosphorylation; Protein protein interaction inhibitor; Structure; Translation initiation

Indexed keywords

INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; INITIATION FACTOR 4G; ANTINEOPLASTIC AGENT; EIF4E PROTEIN, MOUSE; EIF4EBP1 PROTEIN, HUMAN; EIF4ENIF1 PROTEIN, HUMAN; EIF4G1 PROTEIN, HUMAN; EIF4G1 PROTEIN, MOUSE; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; PHOSPHOPROTEIN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA CONTENT; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; INTERNAL RIBOSOME ENTRY SITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN STABILITY; SPIN LABELING; TRANSLATION INITIATION; TUMOR XENOGRAFT; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; CELL PROLIFERATION; CHEMISTRY; ESCHERICHIA COLI; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PHOSPHORYLATION; PROTEIN ANALYSIS; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4G; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84938149443     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1512118112     Document Type: Article

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