A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E

Biochemical Journal

Volumn 441, Issue 1, 2012, Pages 237-245

  Paku, Keum Soon ^a   Umenaga, Yu ^a   Usui, Tsunego ^a   Fukuyo, Ai ^a   Mizuno, Atsuo ^a   In, Yasuko ^a   Ishida, Toshimasa ^b   Tommo, Koji ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b NONE

Author keywords

Eukaryotic initiation factor 4E (eIF4E); Eukaryotic initiation factor 4E binding protein (4E BP); Interaction; Isothermal titration calorimetry; Molecular dynamics simulation; Surface plasmon resonance

Indexed keywords

ARGININE; ASPARTIC ACID; CYSTEINE; GLUTAMINE; GLYCINE; HISTIDINE; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; INITIATION FACTOR 4E BINDING PROTEIN 2; INITIATION FACTOR 4E BINDING PROTEIN 3; ISOLEUCINE; LEUCINE; PROLINE; SERINE; THREONINE; UNCLASSIFIED DRUG; VALINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DELETION MUTANT; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CONSERVED SEQUENCE; ESCHERICHIA COLI; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTORS; GENE EXPRESSION REGULATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RNA, MESSENGER;

EID: 84055178150     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101481     Document Type: Article

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