Association of a novel TAS2R38 haplotype with alcohol intake among Mexican-Mestizo population

Annals of Hepatology

Volumn 14, Issue 5, 2015, Pages 729-734

  Ramos Lopez, Omar ^a,b   Roman, Sonia ^a,b   Martinez Lopez, Erika ^a,b   Gonzalez Aldaco, Karina ^a,b   Ojeda Granados, Claudia ^a,b   Sepulveda Villegas, Maricruz ^a,b   Panduro, Arturo ^a,b  

^a HOSPITAL CIVIL DE GUADALAJARA FRAY ANTONIO ALCALDE   (Mexico)

^b UNIVERSITY OF GUADALAJARA   (Mexico)

Author keywords

Alcohol intake; Bitter taste; Bitter taste perception; Mexico; TAS2R38 haplotypes

Indexed keywords

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; MESTIZO; MEXICAN; PREVALENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TAS2R38 GENE; AMERICAN INDIAN; DRINKING BEHAVIOR; ETHNOLOGY; GENE FREQUENCY; GENETIC ASSOCIATION STUDY; GENETICS; MEXICO; MIDDLE AGED; ODDS RATIO; PHENOTYPE; PSYCHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TASTE; YOUNG ADULT;

G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

ADULT; ALCOHOL DRINKING; CROSS-SECTIONAL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INDIANS, NORTH AMERICAN; MALE; MEXICO; MIDDLE AGED; ODDS RATIO; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; TASTE; TASTE PERCEPTION; YOUNG ADULT;

EID: 84938139819     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)30768-9     Document Type: Article

References (46)

1. Tepper BJ. 6-n-Propylthiouracil: a genetic marker for taste, with implications for food preference and dietary habits. Am J Hum Genet 1998; 63: 1271-6.
2. Campbell MC, Thishkoff SA. The evolution of human genetic and phenotypic variation in Africa. Curr Biol 2010; 20: R166-73.
3. Campbell MC, Ranciaro A, Froment A, Hirbo J, Omar S, Bodo JM, Nyambo T, et al. Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Mol Biol Evol 2012; 29: 1141-53.
4. Garcia-Bailo B, Toguri C, Eny KM, El-Sohemy A. Genetic variation in taste and its influence on food selection. OMICS 2009; 13: 69-80.
5. Noble AC. Bitterness in wine. Physiol Behav 1994; 56: 1251-5.
6. Scinska A, Koros E, Habrat B, Kukwa A, Kostowski W, Bienkowski P. Bitter and sweet components of ethanol taste in humans. Drug Alcohol Depend 2000; 60: 199-206.
7. Kim UK, Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clin Genet 2005; 67: 275-80.
8. El-Sohemy A, Stewart L, Khataan N, Fontaine-Bisson B, Kwong P, Ozsungur S, Cornelis MC. Nutrigenomics of taste - impact on food preferences and food production. Forum Nutr 2007; 60: 176-82.
9. Guo SW, Reed DR. The genetics of phenylthiocarbamide perception. Ann Hum Biol 2001; 28: 111-42.
10. Feeney E, O’Brien S, Scannell A, Markey A, Gibney ER. Genetic variation in taste perception: does it have a role in healthy eating? Proc Nutr Soc 2011; 70: 135-43.
11. Tepper BJ. Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annu Rev Nutr 2008; 28: 367-88.
12. Allen AL, McGeary JE, Hayes JE. Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol. Alcohol Clin Exp Res 2014; 38: 2550-60.
13. Tepper BJ, White EA, Koelliker Y, Lanzara C, d’Adamo P, Gasparini P. Genetic variation in taste sensitivity to 6-npropylthiouracil and its relationship to taste perception and food selection. Ann N Y Acad Sci 2009; 1170: 126-39.
14. Hayes JE, Feeney EL, Allen AL. Do polymorphisms in chemosensory genes matter for human ingestive behavior? Food Qual Prefer 2013; 30: 202-16.
15. Ramos-Lopez O, Ojeda-Granados C, Roman S, Panduro A. Influencia genética en las preferencias alimentarias. Rev Endocrinol Nutr 2013; 21: 74-83.
16. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003; 299: 1221-5.
17. Drayna D. Human taste genetics. Annu Rev Genomics Hum Genet 2005; 6: 217-35.
18. Duffy B, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, et al. Bitter receptor gene (TAS2R38), 6-npropylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res 2004; 28: 1629-37.
19. Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, et al. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcohol Clin Exp Res 2007; 31: 209-15.
20. Hayes JE, Wallace MR, Knopik VS, Herbstman DM, Bastoshuk LM, Duffy VB. Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem Senses 2011; 36: 311-9.
21. Hayes JE, Pickering GJ. Wine Expertise Predicts Taste Phenotype. Am J Enol Vitic 2012; 63: 80-4.
22. Roman S, Zepeda-Carrillo EA, Moreno-Luna LE, Panduro A. Alcoholism and liver disease in Mexico: genetic and environmental factors. World J Gastroenterol 2013; 19: 7972-82.
23. O’Shea RS, Dasarathy S, McCullough AJ; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 2010; 51: 307-28.
24. Cainelli F. Liver diseases in developing countries. World J Hepatol 2012; 4: 66-7.
25. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
26. Tremblay AJ, Morrissette H, Gagné JM, Bergeron J, Gagné C, Couture P. Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with beta-quantification in a large population. Clin Biochem 2004; 37: 785-90.
27. Mennella JA, Pepino MY, Duke FF, Reed DR. Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R 38. BMC Genet 2010; 11: 60.
28. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 2005; 15: 322-7.
29. Kampov-Polevoy AB, Eick C, Boland G, Khalitov E, Crews FT. Sweet liking, novelty seeking, and gender predict alcoholic status. Alcohol Clin Exp Res 2004; 28: 1291-8.
30. Pelchat ML, Danowski S. A possible genetic association between PROP-tasting and alcoholism. Physiol Behav 1992; 51: 1261-6.
31. DiCarlo ST, Powers AS. Propylthiouracil tasting as a possible genetic association marker for two types of alcoholism. Physiol Behav 1998; 64: 147-52.
32. Intranuovo LR, Powers AS. The perceived bitterness of beer and 6-n-propylthiouracil (PROP) taste sensitivity. Ann N Y Acad Sci 1998; 855: 813-5.
33. Kranzler HR, Moore PJ, Hesselbrock VM. No association of PROP taster status and paternal history of alcohol dependence. Alcohol Clin Exp Res 1996; 20: 1496-500.
34. Kranzler HR, Skipsey K, Modesto-Lowe V. PROP taster status and parental history of alcohol dependence. Drug Alcohol Depend 1998; 52: 109-13.
35. Scinska A, Bogucka-Bonikowska A, Koros E, Polanowska E, Habrat B, Kukwa A, Kostowski W, et al. Taste responses in sons of male alcoholics. Alcohol Alcohol 2001; 36: 79-84.
36. Sandstrom KA, Rajan TM, Feinn R, Kranzler HR. Salty and sour taste characteristics and risk of alcoholism. Alcohol Clin Exp Res 2003; 27: 955-61.
37. Kampov-Polevoy AB, Tsoi MV, Zvartau EE, Neznanov NG, Khalitov E. Sweet liking and family history of alcoholism in hospitalized alcoholic and non-alcoholic patients. Alcohol Alcohol 2001; 36: 165-70.
38. Kampov-Polevoy AB, Garbutt JC, Khalitov E. Family history of alcoholism and response to sweets. Alcohol Clin Exp Res 2003; 27: 1743-9.
39. Kampov-Polevoy AB, Ziedonis D, Steinberg ML, Pinsky I, Krejci J, Eick C, Boland G, et al. Association between sweet preference and paternal history of alcoholism in psychiatric and substance abuse patients. Alcohol Clin Exp Res 2003; 27: 1929-36.
40. Wronski M, Skrok-Wolska D, Samochowiec J, Ziolkowski M, Swiecicki L, Bienkowski P, Korkosz A, et al. Perceived intensity and pleasantness of sucrose taste in male alcoholics. Alcohol Alcohol 2007; 42: 75-9.
41. Mustavich LF, Miller P, Kidd KK, Zhao H. Using a pharmacokinetic model to relate and individual’s susceptibility to alcohol dependence to genotypes. Hum Hered 2010; 70: 177-93.
42. Machado IE, Lana FC, Felisbino, Mendes MS, Malta DC.: Factors associated with alcohol intake and alcohol abuse among women in Belo Horizonte, Minas Gerais State, Brazil. Cad Saude Publica 2013; 29: 1449-59.
43. Salguero ML, Leon RE, Santos A, Roman S, Segura-Ortega JE, Panduro A. The role of FABP2 gene polymorphism in alcoholic cirrhosis. Hepatol Res 2005; 33: 306-12.
44. Hernández-Nazará ZH, Ruiz-Madrigal B, Martínez-López E, Roman S, Panduro A. Association of the epsilon 2 allele of APOE gene to hypertriglyceridemia and to early-onset alcoholic cirrhosis. Alcohol Clin Exp Res 2008; 32: 559-66.
45. Gordillo-Bastidas E, Panduro A, Gordillo-Bastidas D, Zepeda- Carrillo EA, García-Bañuelos JJ, Muñoz-Valle JF, Bastidas- Ramírez BE. Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele. Alcohol Clin Exp Res 2010; 34: 142-9.
46. García-Bañuelos J, Panduro A, Gordillo-Bastidas D, Gordillo- Bastidas E, Muñoz-Valle JF, Gurrola-Díaz CM, Sánchez-Enríquez S, et al. Genetic polymorphisms of genes coding to alcohol-metabolizing enzymes in western Mexicans: association of CYP2E1*c2/CYP2E1*5B allele with cirrhosis and liver function. Alcohol Clin Exp Res 2012; 36: 425-31.