Cross-talk between STAT1 and PI3K/AKT signaling in HIV-1-induced blood-brain barrier dysfunction: Role of CCR5 and implications for viral neuropathogenesis

Journal of Neuroscience Research

Volumn 88, Issue 14, 2010, Pages 3090-3101

  Yang, Bo ^a   Singh, Sangya ^a   Bressani, Rafael ^a   Kanmogne, Georgette D ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Brain endothelial cell injury; CCR5; HIV 1; PI3K; STAT1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHEMOKINE RECEPTOR CCR5; FLUDARABINE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE TYK2; PROTEIN SERINE THREONINE KINASE; STAT1 PROTEIN; STAT3 PROTEIN;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER DYSFUNCTION; BRAIN DYSFUNCTION; CELL ADHESION; CELL MIGRATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INTRACELLULAR SIGNALING; MOLECULAR INTERACTION; MONOCYTE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VIRUS VIRULENCE;

AIDS DEMENTIA COMPLEX; BLOOD-BRAIN BARRIER; CELLS, CULTURED; ENDOTHELIAL CELLS; HIV-1; HUMANS; INTERFERON-GAMMA; PHOSPHATIDYLINOSITOL 3-KINASES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR CROSS-TALK; RECEPTORS, CCR5; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR;

EID: 78149352676     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22458     Document Type: Article

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