TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells

Oncogene

Volumn 34, Issue 20, 2015, Pages 2566-2574

  Zhang, Z ^a   Liang, X ^a   Gao, L ^a   Ma, H ^a   Liu, X ^a   Pan, Y ^a   Yan, W ^a   Shan, H ^a   Wang, Z ^b   Chen, Y H ^b   Ma, C ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; NECROSTATIN-1; NEUROPEPTIDE; RAC1 PROTEIN; RAC1 PROTEIN, HUMAN; RAC1 PROTEIN, MOUSE; SIGNAL PEPTIDE; STRESS ACTIVATED PROTEIN KINASE; TIPE1 PROTEIN, HUMAN; TIPE1 PROTEIN, MOUSE;

ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; DRUG EFFECTS; ENZYME ACTIVATION; EXPERIMENTAL LIVER NEOPLASM; GENETICS; HEPG2 CELL LINE; HUMAN; LIVER CELL CARCINOMA; MALE; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; ENZYME ACTIVATION; HEP G2 CELLS; HUMANS; IMIDAZOLES; INDOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED BALB C; NEUROPEPTIDES; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84938091458     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.208     Document Type: Article

References (37)

1. Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B et al. Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis. Cell Prolif 2012; 45: 487-498.
2. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576.
3. Shiraha H, Yamamoto K, Namba M. Human hepatocyte carcinogenesis [review]. Int J Oncol 2013; 42: 1133-1138.
4. Fesik SW. Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 2005; 5: 876-885.
5. Delavallee L, Cabon L, Galan-Malo P, Lorenzo HK, Susin SA. AIF-mediated caspaseindependent necroptosis: A new chance for targeted therapeutics. IUBMB Life 2011; 63: 221-232.
6. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-390.
7. Kumar D, Gokhale P, Broustas C, Chakravarty D, Ahmad I, Kasid U. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. Oncogene 2004; 23: 612-616.
8. Zhang C, Chakravarty D, Sakabe I, Mewani RR, Boudreau HE, Kumar D et al. Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2, MMP-1, and MMP-9 expression. Mol Ther 2006; 13: 947-955.
9. Dong QZ, Zhao Y, Liu Y, Wang Y, Zhang PX, Jiang GY et al. Overexpression of SCC-S2 correlates with lymph node metastasis and poor prognosis in patients with non-small-cell lung cancer. Cancer Sci 2010; 101: 1562-1569.
10. Miao Z, Zhao T, Wang Z, Xu Y, Song Y, Wu J et al. SCC-S2 is overexpressed in colon cancers and regulates cell proliferation. Tumour Biol 2012; 33: 2099-2106.
11. Shi TY, Cheng X, Yu KD, Sun M, Shao ZM, Wang M et al. Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes. Carcinogenesis 2013; 34: 770-778.
12. Woodward MJ, De Boer J, Heidorn S, Hubank M, Kioussis D, Williams O et al. Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes. Cell Death Differ 2010; 17: 316-323.
13. Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J et al. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell 2008; 133: 415-426.
14. Gus-Brautbar Y, Johnson D, Zhang L, Sun H, Wang P, Zhang S et al. The antiinflammatory TIPE2 is an inhibitor of the oncogenic Ras. Mol Cell 2012; 45: 610-618.
15. Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y et al. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. J Immunol 2012; 189: 2768-2773.
16. Wang Z, Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q et al. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proc Natl Acad Sci USA 2012; 109: 15413-15418.
17. Gomez J, Martinez AC, Gonzalez A, Rebollo A. Dual role of Ras and Rho proteins: At the cutting edge of life and death. Immunol Cell Biol 1998; 76: 125-134.
18. Cui J, Zhang G, Hao C, Wang Y, Lou Y, Zhang W et al. The expression of TIPE1 in murine tissues and human cell lines. Mol Immunol 2011; 48: 1548-1555.
19. Wilson KD, Li Z, Wagner R, Yue P, Tsao P, Nestorova G et al. Transcriptome alteration in the diabetic heart by rosiglitazone: Implications for cardiovascular mortality. PLoS One 2008; 3: E2609.
20. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ et al. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008; 135: 1311-1323.
21. Ma CH, Zhang Y, Wang XY, Gao LF, Liu H, Guo C et al. Human endostatin gene transfer, either naked or with liposome, has the same inhibitory effect on growth of mouse liver tumor cells in vivo. World J Gastroenterol 2004; 10: 2874-2877.
22. Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D et al. Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E. Gastroenterology 2012; 142: 1559-1570.
23. Mathews MB, Bernstein RM, Franza BR Jr, Garrels JI. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984; 309: 374-376.
24. Sasi N, Hwang M, Jaboin J, Csiki I, Lu B. Regulated cell death pathways: New twists in modulation of BCL2 family function. Mol Cancer Ther 2009; 8: 1421-1429.
25. Brown JH, Del Re DP, Sussman MA The Rac and Rho hall of fame: A decade of hypertrophic signaling hits. Circ Res 2006; 98: 730-742.
26. Ozen C, Yildiz G, Dagcan A, Cevik D, Ors A, Keles U et al. Genetics and epigenetics of liver cancer. Nat Biotechnol 2013; 30: 381-384.
27. Filmus J, Capurro M. Glypican-3 and alphafetoprotein as diagnostic tests for hepatocellular carcinoma. Mol Diagn 2004; 8: 207-212.
28. Wennerberg K, Der CJ. Rho-family GTPases: It's not only Rac and Rho (and I like it). J Cell Sci 2004; 117: 1301-1312.
29. Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629-635.
30. Rossman KL, Der CJ, Sondek J. GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 2005; 6: 167-180.
31. Mack NA, Whalley HJ, Castillo-Lluva S, Malliri A. The diverse roles of Rac signaling in tumorigenesis. Cell Cycle 2011; 10: 1571-1581.
32. Joneson T, Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol Cell Biol 1999; 19: 5892-5901.
33. Chaigne-Delalande B, Anies G, Kramer I, Genot E. Nonadherent cells switch to a Rac-mediated, SHIP regulated, Akt activation mode for survival. Oncogene 2008; 27: 1876-1885.
34. Debidda M, Williams DA, Zheng Y. Rac1 GTPase regulates cell genomic stability and senescence. J Biol Chem 2006; 281: 38519-38528.
35. Edmondson HA, Steiner PE. Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462-503.
36. Ishak KG. Pathologic features of chronic hepatitis. A review and update. Am J Clin Pathol 2000; 113: 40-55.
37. Luan F, Liu H, Gao L, Liu J, Sun Z, Ju Y et al. Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT. Gut 2009; 58: 1528-1537.