TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15413-15418

  Wang, Zhaojun ^a,b   Fayngerts, Svetlana ^a   Wang, Peng ^a   Sun, Honghong ^a   Johnson, Derek S ^a   Ruan, Qingguo ^a   Guo, Wei ^c   Chen, Youhai H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; RAC PROTEIN; TIPE2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY BURST;

AMINO ACID MOTIFS; ANIMALS; CELL LINE; CELL MEMBRANE; CROSSES, GENETIC; HUMANS; HYDROLYSIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; PROTEIN TRANSPORT; RAC GTP-BINDING PROTEINS; RESPIRATORY BURST; TOLL-LIKE RECEPTORS;

BACTERIA (MICROORGANISMS); MUS;

EID: 84866532480     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204525109     Document Type: Article

References (26)

1. Diebold BA, Bokoch GM (2005) Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes. Curr Top Microbiol Immunol 291:91-111. (Pubitemid 40674912)
2. Niedergang F, Chavrier P (2005) Regulation of phagocytosis by Rho GTPases. Curr Top Microbiol Immunol 291:43-60. (Pubitemid 40674910)
3. Ambruso DR, et al. (2000) Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc Natl Acad Sci USA 97:4654-4659. (Pubitemid 30238613)
4. Roberts AW, et al. (1999) Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10:183-196. (Pubitemid 29115624)
5. Heyworth PG, Cross AR, Curnutte JT (2003) Chronic granulomatous disease. Curr Opin Immunol 15:578-584. (Pubitemid 37130200)
6. Assari T (2006) Chronic granulomatous disease; fundamental stages in our understanding of CGD. Med Immunol 5:4.
7. Colicelli J (2004) Human RAS superfamily proteins and related GTPases. Sci STKE 2004: RE13.
8. Blander JM, Medzhitov R (2004) Regulation of phagosome maturation by signals from toll-like receptors. Science 304:1014-1018. (Pubitemid 38638100)
9. Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17:1-14.
10. Kong L, Ge BX (2008) MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis. Cell Res 18: 745-755. (Pubitemid 351948225)
11. Tricker E, Cheng G (2008) With a little help from my friends: Modulation of phagocytosis through TLR activation. Cell Res 18:711-712. (Pubitemid 351948233)
12. Ahn SH, et al. (2010) Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. PLoS Pathog 6:e1001088.
13. Laliberté B, et al. (2010) TNFAIP8: A new effector for Galpha(i) coupling to reduce cell death and induce cell transformation. J Cell Physiol 225:865-874.
14. Sun H, et al. (2008) TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell 133:415-426. (Pubitemid 351608694)
15. Li D, et al. (2009) Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Immunol 133:422-427.
16. Zhang X, et al. (2009) Crystal structure of TIPE2 provides insights into immune homeostasis. Nat Struct Mol Biol 16:89-90.
17. Zhang G, et al. (2010) Tissue-specific expression of TIPE2 provides insights into its function. Mol Immunol 47:2435-2442.
18. Zhang S, et al. (2010) Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy. Biochim Biophys Acta 1802:1078-1086.
19. Xi W, et al. (2011) Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice. Mol Immunol 48:1203-1208.
20. Zhang C, et al. (2006) Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2, MMP-1, and MMP-9 expression. Mol Ther 13:947-955.
21. Gus-Brautbar Y, et al. (2012) The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras. Mol Cell 45:610-618.
22. Hirshberg M, Stockley RW, Dodson G, Webb MR (1997) The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue. Nat Struct Biol 4:147-152. (Pubitemid 27066390)
23. Kreck ML, Uhlinger DJ, Tyagi SR, Inge KL, Lambeth JD (1994) Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide. J Biol Chem 269:4161-4168.
24. Kreis P, Barnier JV (2009) PAK signalling in neuronal physiology. Cell Signal 21:384-393.
25. West AP, et al. (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472:476-480.
26. Henneke P, et al. (2002) Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol 169:3970-3977.