Protective effects of Notch1 signaling activation against high glucose-induced myocardial cell injury: Analysis of its mechanisms of action

International Journal of Molecular Medicine

Volumn 36, Issue 3, 2015, Pages 897-903

  Zhang, Jian ^a   Li, Bingong ^a   Zheng, Zeqi ^a   Kang, Ting ^a   Zeng, Minghui ^a   Liu, Yanhua ^a   Xia, Baohua ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

Apoptosis; Cardiomyocytes; Connective tissue growth factor; Notch1; PI3K AKT; Transforming growth factor 1

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; GLUCOSE; LENTIVIRUS VECTOR; MESSENGER RNA; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN HEY 1; PROTEIN KINASE B; PROTEIN N1ICD; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; FLOW CYTOMETRY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE INJURY; HEART PROTECTION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MRNA EXPRESSION ASSAY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING; ANIMAL; CARDIAC MUSCLE CELL; CELL LINE; CELL SURVIVAL; CYTOLOGY; METABOLISM; PATHOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; GLUCOSE; MYOCYTES, CARDIAC; RATS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 84938076169     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2294     Document Type: Article

References (33)

1. Fiordaliso F, De Angelis N, Bai A, Cuccovillo I, Salio M, Serra DM, Bianchi R, Razzetti R, Latini R and Masson S: Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats. Life Sci 81: 951-959, 2007.
2. Bell DS: Diabetic cardiomyopathy. Diabetes Care 26: 2949-2951, 2003.
3. Wen HL, Liang ZS, Zhang R and Yang K: Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy. Cardiovasc Diabetol 12: 50, 2013.
4. Leong KG and Karsan A: Recent insights into the role of Notch signaling in tumorigenesis. Blood 107: 2223-2233, 2006.
5. Ji X, Wang Z, Geamanu A, Sarkar FH and Gupta SV: Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. J Cell Biochem 112: 2773-2783, 2011.
6. Cook KM and Figg WD: Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin 60: 222-243, 2010.
7. Lefort K and Dotto GP: Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Semin Cancer Biol 14: 374-386, 2004.
8. Sjölund J, Manetopoulos C, Stockhausen MT and Axelson H: The Notch pathway in cancer: differentiation gone awry. Eur J Cancer 41: 2620-2629, 2005.
9. MacGrogan D, Nus M and de la Pompa JL: Notch signaling in cardiac development and disease. Curr Top Dev Biol 92: 333-365, 2010.
10. Collesi C, Zentilin L, Sinagra G and Giacca M: Notch1 signaling stimulates proliferation of immature cardiomyocytes. J Cell Biol 183: 117-128, 2008.
11. Nemir M, Metrich M, Plaisance I, Lepore M, Cruchet S, Berthonneche C, Sarre A, Radtke F and Pedrazzini T: The Notch pathway controls fibrotic and regenerative repair in the adult heart. Eur Heart J 269: 715-727, 2012.
12. Zhou XL, Wan L and Liu JC: Activated Notch1 reduces myocardial ischemia reperfusion injury in vitro during ischemic postconditioning by crosstalk with the RISK signaling pathway. Chin Med J (Engl) 126: 4545-4551, 2013.
13. Li Y, Hiroi Y and Liao JK: Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction. Trends Cardiovasc Med 20: 228-231, 2010.
14. Gutierrez A and Look AT: NOTCH and PI3K-AKT pathways intertwined. Cancer Cell 12: 411-413, 2007.
15. Li Y, Li B, Zhang C, Zhang J, Zeng M and Zheng Z: Effect of NRG-1/ErbB signaling intervention on the differentiation of bone marrow stromal cells into sinus node-like cells. J Cardiovasc Pharmacol 63: 434-440, 2014.
16. Matsumoto Y, Niimi N and Kohyama K: Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis. Cell Immunol 279: 70-77, 2012.
17. Wang H, Cheng H, Shao Q, Dong Z, Xie Q, Zhao L, Wang Q, Kong B and Qu X: Leptin-promoted human extravillous trophoblast invasion is MMP14 dependent and requires the cross talk between Notch1 and PI3K/Akt signaling. Biol Reprod 90: 78-86, 2014.
18. Xiao W, Chen X and He M: Inhibition of the Jagged/Notch pathway inhibits retinoblastoma cell proliferation via suppressing the PI3K/Akt, Src, p38MAPK and Wnt/β catenin signaling pathways. Mol Med Rep 10: 453-458, 2014.
19. Gude NA, Emmanuel G, Wu W, Cottage CT, Fischer K, Quijada P, Muraski JA, Alvarez R, Rubio M, Schaefer E and Sussman MA: Activation of Notch-mediated protective signaling in the myocardium. Circ Res 102: 1025-1035, 2008.
20. Wang XM, Yao M, Liu SX, Hao J, Liu QJ and Gao F: Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis. Am J Physiol Renal Physiol 306: F205-F213, 2014.
21. Xie F, Su M, Qiu W, Zhang M, Guo Z, Su B, Liu J, Li X and Zhou L: Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. Int J Mol Sci 14: 21215-21226, 2013.
22. Katare RG, Kakinuma Y, Arikawa M, Yamasaki F and Sato T: Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway. J Mol Cell Cardiol 46: 405-412, 2009.
23. Tiwari RV, Parajuli P and Sylvester PW: γ-Tocotrienol-induced autophagy in malignant mammary cancer cells. Exp Biol Med (Maywood) 239: 33-44, 2014.
24. Chang TH, Liu XY, Zhang XH and Wang HL: Effects of dl-praeruptorin A on interleukin-6 level and Fas, bax, bcl-2 protein expression in ischemia-reperfusion myocardium. Acta Pharmacol Sin 23: 769-774, 2002.
25. Yi X, Li X, Zhou Y, Ren S, Wan W, Feng G and Jiang X: Hepatocyte growth factor regulates the TGF-β1-induced proliferation, differentiation and secretory function of cardiac fibroblasts. Int J Mol Med 34: 381-390, 2014.
26. Zhang L, Li Y, Liang C and Yang W: CCN5 overexpression inhibits profibrotic phenotypes via the PI3K/Akt signaling pathway in lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis. Int J Mol Med 33: 478-486, 2014.
27. Wang M, Zhao D, Spinetti G, Zhang J, Jiang LQ, Pintus G, Monticone R and Lakatta EG: Matrix metalloproteinase 2 activation of transforming growth factor-β1 (TGF-β1) and TGF-β1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol 26: 1503-1509, 2006.
28. Beaumont J, López B, Hermida N, Schroen B, San José G, Heymans S, Valencia F, Gómez-Doblas JJ, De Teresa E, Díez J and González A: microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β1 up-regulation. Clin Sci (Lond) 126: 497-506, 2014.
29. Bugyei-Twum A, Advani A, Advani SL, Zhang Y, Thai K, Kelly DJ and Connelly KA: High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy. Cardiovasc Diabetol 13: 89, 2014.
30. Sassoli C, Chellini F, Pini A, Tani A, Nistri S, Nosi D, Zecchi- Orlandini S, Bani D and Formigli L: Relaxin prevents cardiac fibroblast-myofibroblast transition via notch-1-mediated inhibition of TGF-β/Smad3 signaling. PLoS One 8: e63896, 2013.
31. Voloshenyuk TG, Landesman ES, Khoutorova E, Hart AD and Gardner JD: Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling. Cytokine 55: 90-97, 2011.
32. Chung EJ, Sohn YH, Kwon SH, Jung SA and Lee JH: Lithium chloride inhibits TGF-β1-induced myofibroblast transdifferentiation via PI3K/Akt pathway in cultured fibroblasts from Tenon?s capsule of the human eye. Biotechnol Lett 36: 1217-1224, 2014.
33. Liu J, Dong F, Jeong J, Masuda T and Lobe CG: Constitutively active Notch1 signaling promotes endothelial-mesenchymal transition in a conditional transgenic mouse model. Int J Mol Med 34: 669-676, 2014.