Inhibition of the Jagged/Notch pathway inhibits retinoblastoma cell proliferation via suppressing the PI3K/Akt, Src, p38MAPK and Wnt/β-catenin signaling pathways

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 453-458

  Xiao, Wei ^a   Chen, Xiaoyun ^a   He, Mingguang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cell proliferation; DAPT; Notch signaling pathway; Retinoblastoma

Indexed keywords

BETA CATENIN; JAGGED2; MITOGEN ACTIVATED PROTEIN KINASE P38; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VISUAL PIGMENT; WNT PROTEIN; CALCIUM BINDING PROTEIN; DIPEPTIDE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; PROTEIN TYROSINE KINASE; SERRATE PROTEINS; SIGNAL PEPTIDE;

ARTICLE; CARCINOGENESIS; CELL COUNTING; CELL GROWTH; CELL PROLIFERATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINOBLASTOMA; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RETINA TUMOR; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BETA CATENIN; CALCIUM-BINDING PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DIPEPTIDES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, NOTCH; RETINAL NEOPLASMS; RETINOBLASTOMA; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; WNT PROTEINS;

EID: 84901447228     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2213     Document Type: Article

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