CCN5 overexpression inhibits profibrotic phenotypes via the PI3K/Akt signaling pathway in lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis

International Journal of Molecular Medicine

Volumn 33, Issue 2, 2014, Pages 478-486

  Zhang, Lin ^a   Li, Yingna ^a   Liang, Chunlian ^a   Yang, Weilin ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

CCN2; CCN5; Fibroblast; Idiopathic pulmonary fibrosis; Transforming growth factor

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SMOOTH MUSCLE ACTIN; CCN PROTEIN; CCN5 PROTEIN; COLLAGEN TYPE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; EXPRESSION VECTOR; FIBROSING ALVEOLITIS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; NONHUMAN; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTINS; ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CCN INTERCELLULAR SIGNALING PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE MODELS, ANIMAL; FIBROBLASTS; HUMANS; HYDROXYPROLINE; IDIOPATHIC PULMONARY FIBROSIS; LUNG; MICE; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY FIBROSIS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84893808345     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1565     Document Type: Article

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