-
1
-
-
84881116194
-
Systematic Identification of Proteins That Elicit Drug Side Effects
-
Kuhn, M.; Al Banchaabouchi, M.; Campillos, M.; Jensen, L. J.; Gross, C.; Gavin, A. C.; Bork, P. Systematic Identification of Proteins That Elicit Drug Side Effects Mol. Syst. Biol. 2013, 9, 663 10.1038/msb.2013.10
-
(2013)
Mol. Syst. Biol.
, vol.9
, pp. 663
-
-
Kuhn, M.1
Al Banchaabouchi, M.2
Campillos, M.3
Jensen, L.J.4
Gross, C.5
Gavin, A.C.6
Bork, P.7
-
2
-
-
84871595040
-
Drug Side-Effect Prediction Based on the Integration of Chemical and Biological Spaces
-
Yamanishi, Y.; Pauwels, E.; Kotera, M. Drug Side-Effect Prediction Based on the Integration of Chemical and Biological Spaces J. Chem. Inf. Model. 2012, 52, 3284-3292 10.1021/ci2005548
-
(2012)
J. Chem. Inf. Model.
, vol.52
, pp. 3284-3292
-
-
Yamanishi, Y.1
Pauwels, E.2
Kotera, M.3
-
3
-
-
79955969387
-
Predicting Drug Side-Effect Profiles: A Chemical Fragment-Based Approach
-
Pauwels, E.; Stoven, V.; Yamanishi, Y. Predicting Drug Side-Effect Profiles: A Chemical Fragment-Based Approach BMC Bioinf. 2011, 12, 169 10.1186/1471-2105-12-169
-
(2011)
BMC Bioinf.
, vol.12
, pp. 169
-
-
Pauwels, E.1
Stoven, V.2
Yamanishi, Y.3
-
4
-
-
84866460840
-
Relating Drug-Protein Interaction Network with Drug Side Effects
-
Mizutani, S.; Pauwels, E.; Stoven, V.; Goto, S.; Yamanishi, Y. Relating Drug-Protein Interaction Network with Drug Side Effects Bioinformatics 2012, 28, i522-i528 10.1093/bioinformatics/bts383
-
(2012)
Bioinformatics
, vol.28
, pp. i522-i528
-
-
Mizutani, S.1
Pauwels, E.2
Stoven, V.3
Goto, S.4
Yamanishi, Y.5
-
5
-
-
84863548955
-
Large-Scale Prediction of Adverse Drug Reactions Using Chemical, Biological, and Phenotypic Properties of Drugs
-
Liu, M.; Wu, Y.; Chen, Y.; Sun, J.; Zhao, Z.; Chen, X. W.; Matheny, M. E.; Xu, H. Large-Scale Prediction of Adverse Drug Reactions Using Chemical, Biological, and Phenotypic Properties of Drugs J. Am. Med. Inform Assoc 2012, 19, e28-35 10.1136/amiajnl-2011-000699
-
(2012)
J. Am. Med. Inform Assoc
, vol.19
, pp. e28-e35
-
-
Liu, M.1
Wu, Y.2
Chen, Y.3
Sun, J.4
Zhao, Z.5
Chen, X.W.6
Matheny, M.E.7
Xu, H.8
-
6
-
-
79952394490
-
An Algorithmic Framework for Predicting Side Effects of Drugs
-
Atias, N.; Sharan, R. An Algorithmic Framework for Predicting Side Effects of Drugs J. Comput. Biol. 2011, 18, 207-218 10.1089/cmb.2010.0255
-
(2011)
J. Comput. Biol.
, vol.18
, pp. 207-218
-
-
Atias, N.1
Sharan, R.2
-
7
-
-
47249146126
-
Drug Target Identification Using Side-Effect Similarity
-
Campillos, M.; Kuhn, M.; Gavin, A. C.; Jensen, L. J.; Bork, P. Drug Target Identification Using Side-Effect Similarity Science 2008, 321, 263-266 10.1126/science.1158140
-
(2008)
Science
, vol.321
, pp. 263-266
-
-
Campillos, M.1
Kuhn, M.2
Gavin, A.C.3
Jensen, L.J.4
Bork, P.5
-
8
-
-
84861122386
-
Automatic Filtering and Substantiation of Drug Safety Signals
-
Bauer-Mehren, A.; van Mullingen, E. M.; Avillach, P.; Carrascosa Mdel, C.; Garcia-Serna, R.; Pinero, J.; Singh, B.; Lopes, P.; Oliveira, J. L.; Diallo, G.; Ahlberg Helgee, E.; Boyer, S.; Mestres, J.; Sanz, F.; Kors, J. A.; Furlong, L. I. Automatic Filtering and Substantiation of Drug Safety Signals PLoS Comput. Biol. 2012, 8, e1002457 10.1371/journal.pcbi.1002457
-
(2012)
PLoS Comput. Biol.
, vol.8
-
-
Bauer-Mehren, A.1
Van Mullingen, E.M.2
Avillach, P.3
Carrascosa Mdel, C.4
Garcia-Serna, R.5
Pinero, J.6
Singh, B.7
Lopes, P.8
Oliveira, J.L.9
Diallo, G.10
Ahlberg Helgee, E.11
Boyer, S.12
Mestres, J.13
Sanz, F.14
Kors, J.A.15
Furlong, L.I.16
-
9
-
-
78049445175
-
Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
-
Chang, R. L.; Xie, L.; Xie, L.; Bourne, P. E.; Palsson, B. O. Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model PLoS Comput. Biol. 2010, 6, e1000938 10.1371/journal.pcbi.1000938
-
(2010)
PLoS Comput. Biol.
, vol.6
-
-
Chang, R.L.1
Xie, L.2
Xie, L.3
Bourne, P.E.4
Palsson, B.O.5
-
10
-
-
79953100964
-
Structure-Based Systems Biology for Analyzing Off-Target Binding
-
Xie, L.; Xie, L.; Bourne, P. E. Structure-Based Systems Biology for Analyzing Off-Target Binding Curr. Opin. Struct. Biol. 2011, 21, 189-199 10.1016/j.sbi.2011.01.004
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 189-199
-
-
Xie, L.1
Xie, L.2
Bourne, P.E.3
-
11
-
-
33845479693
-
High-Throughput in Vitro Profiling Assays: Lessons Learnt from Experiences at Novartis
-
Faller, B.; Wang, J.; Zimmerlin, A.; Bell, L.; Hamon, J.; Whitebread, S.; Azzaoui, K.; Bojanic, D.; Urban, L. High-Throughput in Vitro Profiling Assays: Lessons Learnt from Experiences at Novartis Expert Opin. Drug Metab. Toxicol. 2006, 2, 823-833 10.1517/17425255.2.6.823
-
(2006)
Expert Opin. Drug Metab. Toxicol.
, vol.2
, pp. 823-833
-
-
Faller, B.1
Wang, J.2
Zimmerlin, A.3
Bell, L.4
Hamon, J.5
Whitebread, S.6
Azzaoui, K.7
Bojanic, D.8
Urban, L.9
-
12
-
-
26944446576
-
Keynote Review: In Vitro Safety Pharmacology Profiling: An Essential Tool for Successful Drug Development
-
Whitebread, S.; Hamon, J.; Bojanic, D.; Urban, L. Keynote Review: In Vitro Safety Pharmacology Profiling: An Essential Tool for Successful Drug Development Drug Discovery Today 2005, 10, 1421-1433 10.1016/S1359-6446(05)03632-9
-
(2005)
Drug Discovery Today
, vol.10
, pp. 1421-1433
-
-
Whitebread, S.1
Hamon, J.2
Bojanic, D.3
Urban, L.4
-
13
-
-
79961007572
-
Trends in the Exploitation of Novel Drug Targets
-
Rask-Andersen, M.; Almen, M. S.; Schioth, H. B. Trends in the Exploitation of Novel Drug Targets Nat. Rev. Drug Discovery 2011, 10, 579-590 10.1038/nrd3478
-
(2011)
Nat. Rev. Drug Discovery
, vol.10
, pp. 579-590
-
-
Rask-Andersen, M.1
Almen, M.S.2
Schioth, H.B.3
-
14
-
-
33749234216
-
Drugs, Their Targets and the Nature and Number of Drug Targets
-
Imming, P.; Sinning, C.; Meyer, A. Drugs, Their Targets and the Nature and Number of Drug Targets Nat. Rev. Drug Discovery 2006, 5, 821-834 10.1038/nrd2132
-
(2006)
Nat. Rev. Drug Discovery
, vol.5
, pp. 821-834
-
-
Imming, P.1
Sinning, C.2
Meyer, A.3
-
15
-
-
84862192766
-
Chembl: A Large-Scale Bioactivity Database for Drug Discovery
-
Gaulton, A.; Bellis, L. J.; Bento, A. P.; Chambers, J.; Davies, M.; Hersey, A.; Light, Y.; McGlinchey, S.; Michalovich, D.; Al-Lazikani, B.; Overington, J. P. Chembl: A Large-Scale Bioactivity Database for Drug Discovery Nucleic Acids Res. 2012, 40, D1100-1107 10.1093/nar/gkr777
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D1100-D1107
-
-
Gaulton, A.1
Bellis, L.J.2
Bento, A.P.3
Chambers, J.4
Davies, M.5
Hersey, A.6
Light, Y.7
McGlinchey, S.8
Michalovich, D.9
Al-Lazikani, B.10
Overington, J.P.11
-
16
-
-
33846108633
-
Bindingdb: A Web-Accessible Database of Experimentally Determined Protein-Ligand Binding Affinities
-
Liu, T.; Lin, Y.; Wen, X.; Jorissen, R. N.; Gilson, M. K. Bindingdb: A Web-Accessible Database of Experimentally Determined Protein-Ligand Binding Affinities Nucleic Acids Res. 2007, 35, D198-201 10.1093/nar/gkl999
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. D198-D201
-
-
Liu, T.1
Lin, Y.2
Wen, X.3
Jorissen, R.N.4
Gilson, M.K.5
-
17
-
-
32344440237
-
Analysis of Drug-Induced Effect Patterns to Link Structure and Side Effects of Medicines
-
Fliri, A. F.; Loging, W. T.; Thadeio, P. F.; Volkmann, R. A. Analysis of Drug-Induced Effect Patterns to Link Structure and Side Effects of Medicines Nat. Chem. Biol. 2005, 1, 389-397 10.1038/nchembio747
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 389-397
-
-
Fliri, A.F.1
Loging, W.T.2
Thadeio, P.F.3
Volkmann, R.A.4
-
18
-
-
27444447278
-
Biospectra Analysis: Model Proteome Characterizations for Linking Molecular Structure and Biological Response
-
Fliri, A. F.; Loging, W. T.; Thadeio, P. F.; Volkmann, R. A. Biospectra Analysis: Model Proteome Characterizations for Linking Molecular Structure and Biological Response J. Med. Chem. 2005, 48, 6918-6925 10.1021/jm050494g
-
(2005)
J. Med. Chem.
, vol.48
, pp. 6918-6925
-
-
Fliri, A.F.1
Loging, W.T.2
Thadeio, P.F.3
Volkmann, R.A.4
-
19
-
-
12244275244
-
Biological Spectra Analysis: Linking Biological Activity Profiles to Molecular Structure
-
Fliri, A. F.; Loging, W. T.; Thadeio, P. F.; Volkmann, R. A. Biological Spectra Analysis: Linking Biological Activity Profiles to Molecular Structure Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 261-266 10.1073/pnas.0407790101
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 261-266
-
-
Fliri, A.F.1
Loging, W.T.2
Thadeio, P.F.3
Volkmann, R.A.4
-
20
-
-
84862510972
-
Large-Scale Prediction and Testing of Drug Activity on Side-Effect Targets
-
Lounkine, E.; Keiser, M. J.; Whitebread, S.; Mikhailov, D.; Hamon, J.; Jenkins, J. L.; Lavan, P.; Weber, E.; Doak, A. K.; Cote, S.; Shoichet, B. K.; Urban, L. Large-Scale Prediction and Testing of Drug Activity on Side-Effect Targets Nature 2012, 486, 361-367 10.1038/nature11159
-
(2012)
Nature
, vol.486
, pp. 361-367
-
-
Lounkine, E.1
Keiser, M.J.2
Whitebread, S.3
Mikhailov, D.4
Hamon, J.5
Jenkins, J.L.6
Lavan, P.7
Weber, E.8
Doak, A.K.9
Cote, S.10
Shoichet, B.K.11
Urban, L.12
-
21
-
-
72149104630
-
Profiling Bioactivity of the Toxcast Chemical Library Using Biomap Primary Human Cell Systems
-
Houck, K. A.; Dix, D. J.; Judson, R. S.; Kavlock, R. J.; Yang, J.; Berg, E. L. Profiling Bioactivity of the Toxcast Chemical Library Using Biomap Primary Human Cell Systems J. Biomol. Screening 2009, 14, 1054-1066 10.1177/1087057109345525
-
(2009)
J. Biomol. Screening
, vol.14
, pp. 1054-1066
-
-
Houck, K.A.1
Dix, D.J.2
Judson, R.S.3
Kavlock, R.J.4
Yang, J.5
Berg, E.L.6
-
22
-
-
84887978605
-
Experimental Confirmation of New Drug-Target Interactions Predicted by Drug Profile Matching
-
Vegner, L.; Peragovics, A.; Tombor, L.; Jelinek, B.; Czobor, P.; Bender, A.; Simon, Z.; Malnasi-Csizmadia, A. Experimental Confirmation of New Drug-Target Interactions Predicted by Drug Profile Matching J. Med. Chem. 2013, 56, 8377-8388 10.1021/jm400813y
-
(2013)
J. Med. Chem.
, vol.56
, pp. 8377-8388
-
-
Vegner, L.1
Peragovics, A.2
Tombor, L.3
Jelinek, B.4
Czobor, P.5
Bender, A.6
Simon, Z.7
Malnasi-Csizmadia, A.8
-
23
-
-
84864633122
-
Prediction of Activity Spectra for Substances
-
Parasuraman, S. Prediction of Activity Spectra for Substances J. Pharmacol. Pharmacother. 2011, 2, 52-53 10.4103/0976-500X.77119
-
(2011)
J. Pharmacol. Pharmacother.
, vol.2
, pp. 52-53
-
-
Parasuraman, S.1
-
24
-
-
77958493840
-
A Novel Framework for Predicting in Vivo Toxicities from in Vitro Data Using Optimal Methods for Dense and Sparse Matrix Reordering and Logistic Regression
-
DiMaggio, P. A., Jr.; Subramani, A.; Judson, R. S.; Floudas, C. A. A Novel Framework for Predicting in Vivo Toxicities from in Vitro Data Using Optimal Methods for Dense and Sparse Matrix Reordering and Logistic Regression Toxicol. Sci. 2010, 118, 251-265 10.1093/toxsci/kfq233
-
(2010)
Toxicol. Sci.
, vol.118
, pp. 251-265
-
-
DiMaggio, P.A.1
Subramani, A.2
Judson, R.S.3
Floudas, C.A.4
-
25
-
-
70049097554
-
A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism
-
Adams, J. C.; Keiser, M. J.; Basuino, L.; Chambers, H. F.; Lee, D. S.; Wiest, O. G.; Babbitt, P. C. A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism PLoS Comput. Biol. 2009, 5, e1000474 10.1371/journal.pcbi.1000474
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Adams, J.C.1
Keiser, M.J.2
Basuino, L.3
Chambers, H.F.4
Lee, D.S.5
Wiest, O.G.6
Babbitt, P.C.7
-
26
-
-
80053906388
-
Chemical Structural Novelty: On-Targets and Off-Targets
-
Yera, E. R.; Cleves, A. E.; Jain, A. N. Chemical Structural Novelty: On-Targets and Off-Targets J. Med. Chem. 2011, 54, 6771-6785 10.1021/jm200666a
-
(2011)
J. Med. Chem.
, vol.54
, pp. 6771-6785
-
-
Yera, E.R.1
Cleves, A.E.2
Jain, A.N.3
-
27
-
-
44449139387
-
Detecting Evolutionary Relationships across Existing Fold Space, Using Sequence Order-Independent Profile-Profile Alignments
-
Xie, L.; Bourne, P. E. Detecting Evolutionary Relationships across Existing Fold Space, Using Sequence Order-Independent Profile-Profile Alignments Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 5441-5446 10.1073/pnas.0704422105
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 5441-5446
-
-
Xie, L.1
Bourne, P.E.2
-
28
-
-
66349119013
-
A Unified Statistical Model to Support Local Sequence Order Independent Similarity Searching for Ligand-Binding Sites and Its Application to Genome-Based Drug Discovery
-
Xie, L.; Bourne, P. E. A Unified Statistical Model to Support Local Sequence Order Independent Similarity Searching for Ligand-Binding Sites and Its Application to Genome-Based Drug Discovery Bioinformatics 2009, 25, i305-312 10.1093/bioinformatics/btp220
-
(2009)
Bioinformatics
, vol.25
, pp. i305-i312
-
-
Xie, L.1
Bourne, P.E.2
-
29
-
-
84855286318
-
Using Multiple Microenvironments to Find Similar Ligand-Binding Sites: Application to Kinase Inhibitor Binding
-
Liu, T.; Altman, R. B. Using Multiple Microenvironments to Find Similar Ligand-Binding Sites: Application to Kinase Inhibitor Binding PLoS Comput. Biol. 2011, 7, e1002326 10.1371/journal.pcbi.1002326
-
(2011)
PLoS Comput. Biol.
, vol.7
-
-
Liu, T.1
Altman, R.B.2
-
30
-
-
84880763942
-
Target Essentiality and Centrality Characterize Drug Side Effects
-
Wang, X.; Thijssen, B.; Yu, H. Target Essentiality and Centrality Characterize Drug Side Effects PLoS Comput. Biol. 2013, 9, e1003119 10.1371/journal.pcbi.1003119
-
(2013)
PLoS Comput. Biol.
, vol.9
-
-
Wang, X.1
Thijssen, B.2
Yu, H.3
-
31
-
-
38849192515
-
Profiling Essential Genes in Human Mammary Cells by Multiplex Rnai Screening
-
Silva, J. M.; Marran, K.; Parker, J. S.; Silva, J.; Golding, M.; Schlabach, M. R.; Elledge, S. J.; Hannon, G. J.; Chang, K. Profiling Essential Genes in Human Mammary Cells by Multiplex Rnai Screening Science 2008, 319, 617-620 10.1126/science.1149185
-
(2008)
Science
, vol.319
, pp. 617-620
-
-
Silva, J.M.1
Marran, K.2
Parker, J.S.3
Silva, J.4
Golding, M.5
Schlabach, M.R.6
Elledge, S.J.7
Hannon, G.J.8
Chang, K.9
-
32
-
-
68249128647
-
Harvesting Candidate Genes Responsible for Serious Adverse Drug Reactions from a Chemical-Protein Interactome
-
Yang, L.; Chen, J.; He, L. Harvesting Candidate Genes Responsible for Serious Adverse Drug Reactions from a Chemical-Protein Interactome PLoS Comput. Biol. 2009, 5, e1000441 10.1371/journal.pcbi.1000441
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Yang, L.1
Chen, J.2
He, L.3
-
33
-
-
77957954504
-
A Structure-Based Approach for Mapping Adverse Drug Reactions to the Perturbation of Underlying Biological Pathways
-
Wallach, I.; Jaitly, N.; Lilien, R. A Structure-Based Approach for Mapping Adverse Drug Reactions to the Perturbation of Underlying Biological Pathways PLoS One 2010, 5, e12063 10.1371/journal.pone.0012063
-
(2010)
PLoS One
, vol.5
-
-
Wallach, I.1
Jaitly, N.2
Lilien, R.3
-
34
-
-
0000107975
-
Relations between Two Sets of Variates
-
Hotelling, H. Relations between Two Sets of Variates Biometrika 1936, 28, 321 10.2307/2333955
-
(1936)
Biometrika
, vol.28
, pp. 321
-
-
Hotelling, H.1
-
35
-
-
10044285992
-
Canonical Correlation Analysis: An Overview with Application to Learning Methods
-
Hardoon, D. R.; Szedmak, S.; Shawe-Taylor, J. Canonical Correlation Analysis: An Overview with Application to Learning Methods Neural Comput 2004, 16, 2639-2664 10.1162/0899766042321814
-
(2004)
Neural Comput
, vol.16
, pp. 2639-2664
-
-
Hardoon, D.R.1
Szedmak, S.2
Shawe-Taylor, J.3
-
36
-
-
70149096300
-
A Penalized Matrix Decomposition, with Applications to Sparse Principal Components and Canonical Correlation Analysis
-
Witten, D. M.; Tibshirani, R.; Hastie, T. A Penalized Matrix Decomposition, with Applications to Sparse Principal Components and Canonical Correlation Analysis Biostatistics 2009, 10, 515-534 10.1093/biostatistics/kxp008
-
(2009)
Biostatistics
, vol.10
, pp. 515-534
-
-
Witten, D.M.1
Tibshirani, R.2
Hastie, T.3
-
37
-
-
76149120425
-
A Side Effect Resource to Capture Phenotypic Effects of Drugs
-
Kuhn, M.; Campillos, M.; Letunic, I.; Jensen, L. J.; Bork, P. A Side Effect Resource to Capture Phenotypic Effects of Drugs Mol. Syst. Biol. 2010, 6, 343 10.1038/msb.2009.98
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 343
-
-
Kuhn, M.1
Campillos, M.2
Letunic, I.3
Jensen, L.J.4
Bork, P.5
-
38
-
-
0024268931
-
Point Mutations in the Human Vitamin D Receptor Gene Associated with Hypocalcemic Rickets
-
Hughes, M. R.; Malloy, P. J.; Kieback, D. G.; Kesterson, R. A.; Pike, J. W.; Feldman, D.; O'Malley, B. W. Point Mutations in the Human Vitamin D Receptor Gene Associated with Hypocalcemic Rickets Science 1988, 242, 1702-1705 10.1126/science.2849209
-
(1988)
Science
, vol.242
, pp. 1702-1705
-
-
Hughes, M.R.1
Malloy, P.J.2
Kieback, D.G.3
Kesterson, R.A.4
Pike, J.W.5
Feldman, D.6
O'Malley, B.W.7
-
39
-
-
33845732323
-
DNA Polymerase Beta Null Mouse Embryonic Fibroblasts Harbor a Homozygous Null Mutation in DNA Polymerase Iota
-
Sobol, R. W. DNA Polymerase Beta Null Mouse Embryonic Fibroblasts Harbor a Homozygous Null Mutation in DNA Polymerase Iota DNA Repair 2007, 6, 3-7 10.1016/j.dnarep.2006.08.005
-
(2007)
DNA Repair
, vol.6
, pp. 3-7
-
-
Sobol, R.W.1
-
40
-
-
0033829565
-
Hiv Protease Inhibitors Block Adipogenesis and Increase Lipolysis in Vitro
-
Lenhard, J. M.; Furfine, E. S.; Jain, R. G.; Ittoop, O.; Orband-Miller, L. A.; Blanchard, S. G.; Paulik, M. A.; Weiel, J. E. Hiv Protease Inhibitors Block Adipogenesis and Increase Lipolysis in Vitro Antiviral Res. 2000, 47, 121-129 10.1016/S0166-3542(00)00102-9
-
(2000)
Antiviral Res.
, vol.47
, pp. 121-129
-
-
Lenhard, J.M.1
Furfine, E.S.2
Jain, R.G.3
Ittoop, O.4
Orband-Miller, L.A.5
Blanchard, S.G.6
Paulik, M.A.7
Weiel, J.E.8
-
41
-
-
35248817286
-
Modeling Promiscuity Based on in Vitro Safety Pharmacology Profiling Data
-
Azzaoui, K.; Hamon, J.; Faller, B.; Whitebread, S.; Jacoby, E.; Bender, A.; Jenkins, J. L.; Urban, L. Modeling Promiscuity Based on in Vitro Safety Pharmacology Profiling Data ChemMedChem 2007, 2, 874-880 10.1002/cmdc.200700036
-
(2007)
ChemMedChem
, vol.2
, pp. 874-880
-
-
Azzaoui, K.1
Hamon, J.2
Faller, B.3
Whitebread, S.4
Jacoby, E.5
Bender, A.6
Jenkins, J.L.7
Urban, L.8
-
42
-
-
33751547539
-
How Many Drug Targets Are There?
-
Overington, J. P.; Al-Lazikani, B.; Hopkins, A. L. How Many Drug Targets Are There? Nat. Rev. Drug Discovery 2006, 5, 993-996 10.1038/nrd2199
-
(2006)
Nat. Rev. Drug Discovery
, vol.5
, pp. 993-996
-
-
Overington, J.P.1
Al-Lazikani, B.2
Hopkins, A.L.3
-
43
-
-
84891767304
-
Drugbank 4.0: Shedding New Light on Drug Metabolism
-
Law, V.; Knox, C.; Djoumbou, Y.; Jewison, T.; Guo, A. C.; Liu, Y.; Maciejewski, A.; Arndt, D.; Wilson, M.; Neveu, V.; Tang, A.; Gabriel, G.; Ly, C.; Adamjee, S.; Dame, Z. T.; Han, B.; Zhou, Y.; Wishart, D. S. Drugbank 4.0: Shedding New Light on Drug Metabolism Nucleic Acids Res. 2014, 42, D1091-1097 10.1093/nar/gkt1068
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. D1091-D1097
-
-
Law, V.1
Knox, C.2
Djoumbou, Y.3
Jewison, T.4
Guo, A.C.5
Liu, Y.6
Maciejewski, A.7
Arndt, D.8
Wilson, M.9
Neveu, V.10
Tang, A.11
Gabriel, G.12
Ly, C.13
Adamjee, S.14
Dame, Z.T.15
Han, B.16
Zhou, Y.17
Wishart, D.S.18
-
44
-
-
84901296367
-
Identifying Druggable Targets by Protein Microenvironments Matching: Application to Transcription Factors
-
Liu, T.; Altman, R. B. Identifying Druggable Targets by Protein Microenvironments Matching: Application to Transcription Factors CPT: Pharmacometrics Syst. Pharmacol. 2014, 3, e93 10.1038/psp.2013.66
-
(2014)
CPT: Pharmacometrics Syst. Pharmacol.
, vol.3
, pp. e93
-
-
Liu, T.1
Altman, R.B.2
-
45
-
-
0031306229
-
Using the Radial Distributions of Physical Features to Compare Amino Acid Environments and Align Amino Acid Sequences
-
Wei, L.; Altman, R. B.; Chang, J. T. Using the Radial Distributions of Physical Features to Compare Amino Acid Environments and Align Amino Acid Sequences Pac Symp. Biocomput 1997, 465-476
-
Pac Symp. Biocomput 1997
, pp. 465-476
-
-
Wei, L.1
Altman, R.B.2
Chang, J.T.3
|