-
1
-
-
0032522873
-
Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies
-
Lazarou J, Pomeranz BH, Corey PN, (1998) Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 279: 1200-1205.
-
(1998)
JAMA
, vol.279
, pp. 1200-1205
-
-
Lazarou, J.1
Pomeranz, B.H.2
Corey, P.N.3
-
2
-
-
34247604930
-
When good drugs go bad
-
Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, et al. (2007) When good drugs go bad. Nature 446: 975-977.
-
(2007)
Nature
, vol.446
, pp. 975-977
-
-
Giacomini, K.M.1
Krauss, R.M.2
Roden, D.M.3
Eichelbaum, M.4
Hayden, M.R.5
-
3
-
-
84855549380
-
Reinventing clinical trials
-
Allison M, (2012) Reinventing clinical trials. Nat Biotechnol 30: 41-49.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 41-49
-
-
Allison, M.1
-
4
-
-
84855882587
-
Novel computational approaches to polypharmacology as a means to define responses to individual drugs
-
Xie L, Kinnings SL, Bourne PE, (2012) Novel computational approaches to polypharmacology as a means to define responses to individual drugs. Annu Rev Pharmacol Toxicol 52: 361-379.
-
(2012)
Annu Rev Pharmacol Toxicol
, vol.52
, pp. 361-379
-
-
Xie, L.1
Kinnings, S.L.2
Bourne, P.E.3
-
5
-
-
79955969387
-
Predicting drug side-effect profiles: a chemical fragment-based approach
-
Pauwels E, Stoven V, Yamanishi Y, (2011) Predicting drug side-effect profiles: a chemical fragment-based approach. BMC Bioinformatics 12: 169.
-
(2011)
BMC Bioinformatics
, vol.12
, pp. 169
-
-
Pauwels, E.1
Stoven, V.2
Yamanishi, Y.3
-
6
-
-
0043031339
-
Predicting ADME properties and side effects: the BioPrint approach
-
Krejsa CM, Horvath D, Rogalski SL, Penzotti JE, Mao B, et al. (2003) Predicting ADME properties and side effects: the BioPrint approach. Curr Opin Drug Discov Devel 6: 470-480.
-
(2003)
Curr Opin Drug Discov Devel
, vol.6
, pp. 470-480
-
-
Krejsa, C.M.1
Horvath, D.2
Rogalski, S.L.3
Penzotti, J.E.4
Mao, B.5
-
7
-
-
26844538190
-
Visual side effects associated with erectile dysfunction agents
-
Fraunfelder FW, (2005) Visual side effects associated with erectile dysfunction agents. Am J Ophthalmol 140: 723-724.
-
(2005)
Am J Ophthalmol
, vol.140
, pp. 723-724
-
-
Fraunfelder, F.W.1
-
8
-
-
0242331764
-
FDA alerts asthmatics to drug safety risk
-
Ellis C, (2003) FDA alerts asthmatics to drug safety risk. Nat Rev Drug Discov 2: 765.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 765
-
-
Ellis, C.1
-
9
-
-
78650373804
-
Network medicine: a network-based approach to human disease
-
Barabasi AL, Gulbahce N, Loscalzo J, (2011) Network medicine: a network-based approach to human disease. Nat Rev Genet 12: 56-68.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 56-68
-
-
Barabasi, A.L.1
Gulbahce, N.2
Loscalzo, J.3
-
10
-
-
54249155522
-
Network pharmacology: the next paradigm in drug discovery
-
Hopkins AL, (2008) Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4: 682-690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
11
-
-
80054991882
-
Network-based methods for human disease gene prediction
-
Wang X, Gulbahce N, Yu H, (2011) Network-based methods for human disease gene prediction. Brief Funct Genomics 10: 280-293.
-
(2011)
Brief Funct Genomics
, vol.10
, pp. 280-293
-
-
Wang, X.1
Gulbahce, N.2
Yu, H.3
-
12
-
-
84863010950
-
Three-dimensional reconstruction of protein networks provides insight into human genetic disease
-
Wang X, Wei X, Thijssen B, Das J, Lipkin SM, et al. (2012) Three-dimensional reconstruction of protein networks provides insight into human genetic disease. Nat Biotechnol 30: 159-164.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 159-164
-
-
Wang, X.1
Wei, X.2
Thijssen, B.3
Das, J.4
Lipkin, S.M.5
-
13
-
-
47249146126
-
Drug target identification using side-effect similarity
-
Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P, (2008) Drug target identification using side-effect similarity. Science 321: 263-266.
-
(2008)
Science
, vol.321
, pp. 263-266
-
-
Campillos, M.1
Kuhn, M.2
Gavin, A.C.3
Jensen, L.J.4
Bork, P.5
-
14
-
-
79960238966
-
Network neighbors of drug targets contribute to drug side-effect similarity
-
Brouwers L, Iskar M, Zeller G, van Noort V, Bork P, (2011) Network neighbors of drug targets contribute to drug side-effect similarity. PLoS One 6: e22187.
-
(2011)
PLoS One
, vol.6
-
-
Brouwers, L.1
Iskar, M.2
Zeller, G.3
van Noort, V.4
Bork, P.5
-
15
-
-
73549090972
-
Structure of protein interaction networks and their implications on drug design
-
Hase T, Tanaka H, Suzuki Y, Nakagawa S, Kitano H, (2009) Structure of protein interaction networks and their implications on drug design. PLoS Comput Biol 5: e1000550.
-
(2009)
PLoS Comput Biol
, vol.5
-
-
Hase, T.1
Tanaka, H.2
Suzuki, Y.3
Nakagawa, S.4
Kitano, H.5
-
16
-
-
76149120425
-
A side effect resource to capture phenotypic effects of drugs
-
Kuhn M, Campillos M, Letunic I, Jensen LJ, Bork P, (2010) A side effect resource to capture phenotypic effects of drugs. Mol Syst Biol 6: 343.
-
(2010)
Mol Syst Biol
, vol.6
, pp. 343
-
-
Kuhn, M.1
Campillos, M.2
Letunic, I.3
Jensen, L.J.4
Bork, P.5
-
17
-
-
78651287426
-
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
-
Knox C, Law V, Jewison T, Liu P, Ly S, et al. (2011) DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39: D1035-1041.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Knox, C.1
Law, V.2
Jewison, T.3
Liu, P.4
Ly, S.5
-
18
-
-
79952674000
-
Interactome networks and human disease
-
Vidal M, Cusick ME, Barabasi AL, (2011) Interactome networks and human disease. Cell 144: 986-998.
-
(2011)
Cell
, vol.144
, pp. 986-998
-
-
Vidal, M.1
Cusick, M.E.2
Barabasi, A.L.3
-
19
-
-
34247622363
-
The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics
-
Yu H, Kim PM, Sprecher E, Trifonov V, Gerstein M, (2007) The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics. PLoS Comput Biol 3: e59.
-
(2007)
PLoS Comput Biol
, vol.3
-
-
Yu, H.1
Kim, P.M.2
Sprecher, E.3
Trifonov, V.4
Gerstein, M.5
-
20
-
-
33845875196
-
Relating three-dimensional structures to protein networks provides evolutionary insights
-
Kim PM, Lu LJ, Xia Y, Gerstein MB, (2006) Relating three-dimensional structures to protein networks provides evolutionary insights. Science 314: 1938-1941.
-
(2006)
Science
, vol.314
, pp. 1938-1941
-
-
Kim, P.M.1
Lu, L.J.2
Xia, Y.3
Gerstein, M.B.4
-
21
-
-
84862510972
-
Large-scale prediction and testing of drug activity on side-effect targets
-
Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, et al. (2012) Large-scale prediction and testing of drug activity on side-effect targets. Nature 486: 361-367.
-
(2012)
Nature
, vol.486
, pp. 361-367
-
-
Lounkine, E.1
Keiser, M.J.2
Whitebread, S.3
Mikhailov, D.4
Hamon, J.5
-
22
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
Knight ZA, Lin H, Shokat KM, (2010) Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 10: 130-137.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
23
-
-
84856918212
-
HIPPIE: Integrating protein interaction networks with experiment based quality scores
-
Schaefer MH, Fontaine JF, Vinayagam A, Porras P, Wanker EE, et al. (2012) HIPPIE: Integrating protein interaction networks with experiment based quality scores. PLoS One 7: e31826.
-
(2012)
PLoS One
, vol.7
-
-
Schaefer, M.H.1
Fontaine, J.F.2
Vinayagam, A.3
Porras, P.4
Wanker, E.E.5
-
24
-
-
67849104638
-
PubChem: a public information system for analyzing bioactivities of small molecules
-
Wang Y, Xiao J, Suzek TO, Zhang J, Wang J, et al. (2009) PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res 37: W623-633.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Wang, Y.1
Xiao, J.2
Suzek, T.O.3
Zhang, J.4
Wang, J.5
-
26
-
-
34547140875
-
The human disease network
-
Goh KI, Cusick ME, Valle D, Childs B, Vidal M, et al. (2007) The human disease network. Proc Natl Acad Sci USA 104: 8685-8690.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
Cusick, M.E.2
Valle, D.3
Childs, B.4
Vidal, M.5
-
27
-
-
38849192515
-
Profiling essential genes in human mammary cells by multiplex RNAi screening
-
Silva JM, Marran K, Parker JS, Silva J, Golding M, et al. (2008) Profiling essential genes in human mammary cells by multiplex RNAi screening. Science 319: 617-620.
-
(2008)
Science
, vol.319
, pp. 617-620
-
-
Silva, J.M.1
Marran, K.2
Parker, J.S.3
Silva, J.4
Golding, M.5
-
28
-
-
79957874673
-
Next-generation sequencing to generate interactome datasets
-
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, et al. (2011) Next-generation sequencing to generate interactome datasets. Nat Methods 8: 478-480.
-
(2011)
Nat Methods
, vol.8
, pp. 478-480
-
-
Yu, H.1
Tardivo, L.2
Tam, S.3
Weiner, E.4
Gebreab, F.5
-
29
-
-
58149305794
-
An empirical framework for binary interactome mapping
-
Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, et al. (2009) An empirical framework for binary interactome mapping. Nat Methods 6: 83-90.
-
(2009)
Nat Methods
, vol.6
, pp. 83-90
-
-
Venkatesan, K.1
Rual, J.F.2
Vazquez, A.3
Stelzl, U.4
Lemmens, I.5
-
30
-
-
25144498379
-
A human protein-protein interaction network: a resource for annotating the proteome
-
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122: 957-968.
-
(2005)
Cell
, vol.122
, pp. 957-968
-
-
Stelzl, U.1
Worm, U.2
Lalowski, M.3
Haenig, C.4
Brembeck, F.H.5
-
31
-
-
27144530248
-
Towards a proteome-scale map of the human protein-protein interaction network
-
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437: 1173-1178.
-
(2005)
Nature
, vol.437
, pp. 1173-1178
-
-
Rual, J.F.1
Venkatesan, K.2
Hao, T.3
Hirozane-Kishikawa, T.4
Dricot, A.5
-
32
-
-
58149193222
-
Human Protein Reference Database-2009 update
-
Keshava Prasad TS, Goel R, Kandasamy K, Keerthikumar S, Kumar S, et al. (2009) Human Protein Reference Database-2009 update. Nucleic Acids Res 37: D767-772.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Keshava Prasad, T.S.1
Goel, R.2
Kandasamy, K.3
Keerthikumar, S.4
Kumar, S.5
-
33
-
-
38549173606
-
The BioGRID Interaction Database: 2008 update
-
Breitkreutz BJ, Stark C, Reguly T, Boucher L, Breitkreutz A, et al. (2008) The BioGRID Interaction Database: 2008 update. Nucleic Acids Res 36: D637-640.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Breitkreutz, B.J.1
Stark, C.2
Reguly, T.3
Boucher, L.4
Breitkreutz, A.5
-
34
-
-
75549087047
-
The IntAct molecular interaction database in 2010
-
Aranda B, Achuthan P, Alam-Faruque Y, Armean I, Bridge A, et al. (2010) The IntAct molecular interaction database in 2010. Nucleic Acids Res 38: D525-531.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Aranda, B.1
Achuthan, P.2
Alam-Faruque, Y.3
Armean, I.4
Bridge, A.5
-
35
-
-
75549083295
-
MINT, the molecular interaction database: 2009 update
-
Ceol A, Chatr Aryamontri A, Licata L, Peluso D, Briganti L, et al. (2010) MINT, the molecular interaction database: 2009 update. Nucleic Acids Res 38: D532-539.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Ceol, A.1
Chatr Aryamontri, A.2
Licata, L.3
Peluso, D.4
Briganti, L.5
-
36
-
-
67849122322
-
VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology
-
Hu Z, Hung JH, Wang Y, Chang YC, Huang CL, et al. (2009) VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology. Nucleic Acids Res 37: W115-121.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Hu, Z.1
Hung, J.H.2
Wang, Y.3
Chang, Y.C.4
Huang, C.L.5
-
37
-
-
79952052352
-
iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence
-
Turner B, Razick S, Turinsky AL, Vlasblom J, Crowdy EK, et al. (2010) iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence. Database (Oxford) 2010: baq023.
-
(2010)
Database (Oxford)
, vol.2010
-
-
Turner, B.1
Razick, S.2
Turinsky, A.L.3
Vlasblom, J.4
Crowdy, E.K.5
-
38
-
-
58149213932
-
Literature-curated protein interaction datasets
-
Cusick ME, Yu H, Smolyar A, Venkatesan K, Carvunis AR, et al. (2009) Literature-curated protein interaction datasets. Nat Methods 6: 39-46.
-
(2009)
Nat Methods
, vol.6
, pp. 39-46
-
-
Cusick, M.E.1
Yu, H.2
Smolyar, A.3
Venkatesan, K.4
Carvunis, A.R.5
-
39
-
-
79952676403
-
Literature curation of protein interactions: measuring agreement across major public databases
-
Turinsky AL, Razick S, Turner B, Donaldson IM, Wodak SJ, (2010) Literature curation of protein interactions: measuring agreement across major public databases. Database (Oxford) 2010: baq026.
-
(2010)
Database (Oxford)
, vol.2010
-
-
Turinsky, A.L.1
Razick, S.2
Turner, B.3
Donaldson, I.M.4
Wodak, S.J.5
-
40
-
-
0033954256
-
The Protein Data Bank
-
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, et al. (2000) The Protein Data Bank. Nucleic Acids Res 28: 235-242.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
-
41
-
-
77953446523
-
The Human Gene Mutation Database: 2008 update
-
Stenson PD, Mort M, Ball EV, Howells K, Phillips AD, et al. (2009) The Human Gene Mutation Database: 2008 update. Genome Med 1: 13.
-
(2009)
Genome Med
, vol.1
, pp. 13
-
-
Stenson, P.D.1
Mort, M.2
Ball, E.V.3
Howells, K.4
Phillips, A.D.5
|