Engineered biosynthesis of pimaricin derivatives with improved antifungal activity and reduced cytotoxicity

Applied Microbiology and Biotechnology

Volumn 99, Issue 16, 2015, Pages 6745-6752

  Qi, Zhen ^a,b   Kang, Qianjin ^a,b   Jiang, Chunyan ^a,b   Han, Mo ^a,b   Bai, Linquan ^a,b  

^a Shanghai Jiao Tong University   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Antifungal activity; Cytotoxicity; Pimaricin; Polyene macrolide; Streptomyces

Indexed keywords

BACTERIA; BIOCHEMISTRY; CYTOTOXICITY; FUNGI; GENETIC ENGINEERING;

ANTI-FUNGAL ACTIVITY; ANTIFUNGAL ANTIBIOTICS; ENGINEERED BIOSYNTHESIS; MOULD CONTAMINATIONS; PHARMACOLOGICAL PROPERTIES; PIMARICIN; POLYENE MACROLIDE; STREPTOMYCES;

ANTIFUNGAL AGENTS;

12 DECARBOXY 12 METHYL PIMARICIN; 2 HYDRO 3 HYDROXY 4,5 DESEPOXY 12 DECARBOXY 12 METHYL PIMARICIN; 4,5 DESEPOXY 12 DECARBOXY 12 METHYL PIMARICIN; ANTIFUNGAL AGENT; CYTOCHROME P450; NATAMYCIN; PIMARICIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; BACTERIUM; BIOCHEMICAL COMPOSITION; BIOENGINEERING; FOOD INDUSTRY; GENE EXPRESSION; GENETIC ANALYSIS; TOXICITY;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOCHEMICAL ANALYSIS; BIOSYNTHESIS; CANDIDA ALBICANS; CATALYSIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; ERYTHROCYTE; FUNGAL STRAIN; GENE INACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC ENGINEERING; HEMOLYSIS; IN VITRO STUDY; NONHUMAN; STREPTOMYCES; STREPTOMYCES CHATTANOOGENSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLIC ENGINEERING; METABOLISM; MICROBIAL SENSITIVITY TEST;

CANDIDA ALBICANS; STREPTOMYCES; STREPTOMYCES CHATTANOOGENSIS;

ANTIFUNGAL AGENTS; BIOSYNTHETIC PATHWAYS; CANDIDA ALBICANS; METABOLIC ENGINEERING; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NATAMYCIN; STREPTOMYCES;

EID: 84937972288     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6635-9     Document Type: Article

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