Probing the structure-function relationship of polyene macrolides: Engineered biosynthesis of soluble nystatin analogues

Journal of Medicinal Chemistry

Volumn 49, Issue 8, 2006, Pages 2431-2439

  Borgos, Sven E F ^a   Tsan, Pascale ^b   Sletta, Håvard ^c   Ellingsen, Trond E ^c   Lancelin, Jean Marc ^b   Zotchev, Sergey B ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITÉ LYON 1   (France)

^c SINTEF MATERIALS AND CHEMISTRY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; MACROLIDE; NYSTATIN; NYSTATIN DERIVATIVE; POLYENE ANTIBIOTIC AGENT; POLYKETIDE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOSYNTHESIS; CANDIDA ALBICANS; COMPUTER MODEL; CONFORMATIONAL TRANSITION; FUNGICIDAL ACTIVITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SOLUBILITY; STREPTOMYCES; STREPTOMYCES NOURSEI; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; GENETIC ENGINEERING; MACROLIDES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; NYSTATIN; POLYENES; SOLUBILITY; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646112405     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050895w     Document Type: Article

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