Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization

Biochemical and Biophysical Research Communications

Volumn 460, Issue 2, 2015, Pages 198-204

  Meng, Zhen ^a   Gan, Ye Hua ^a  

^a PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

Author keywords

AKT; Celecoxib; COX 2; PTEN; Radiation; Valdecoxib

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PTEN PROTEIN, HUMAN; PYRAZOLE DERIVATIVE; SULFONAMIDE;

CHROMOSOME 10; ENZYME ACTIVATION; HUMAN; IONIZING RADIATION; METABOLISM; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 10; CYCLOOXYGENASE 2 INHIBITORS; ENZYME ACTIVATION; HUMANS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; PYRAZOLES; RADIATION, IONIZING; REAL-TIME POLYMERASE CHAIN REACTION; SULFONAMIDES;

EID: 84937965784     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.008     Document Type: Article

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