Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells

International Journal of Radiation Oncology Biology Physics

Volumn 48, Issue 2, 2000, Pages 325-328

  Steinauer, Kirsten K ^a   Gibbs, Iris ^a   Ning, Shoucheng ^a   French, John N ^a   Armstrong, Jeff ^a   Knox, Susan J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclooxygenase 2; NS 398; Prostaglandin E2; Prostate cancer; Radiation

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; FLOW CYTOMETRY; GAMMA IRRADIATION; HUMAN; HUMAN CELL; IMMUNOASSAY; IRRADIATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROSTATE; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL CYCLE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; ENZYME ACTIVATION; GAMMA RAYS; HUMANS; ISOENZYMES; MALE; MEMBRANE PROTEINS; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SULFONAMIDES; TIME FACTORS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0033828752     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)00671-4     Document Type: Article

References (18)

1. Williams C.S., Mann M., DuBois R.N. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 18:1999;7908-7916.
2. Michalowski A.S. On radiation damage to normal tissues and its treatment. II. Anti-inflammatory drugs. Acta Oncol. 33:1994;139-157.
3. Chen X., Gresham A., Morrison A., et al. Oxidative stress mediates synthesis of cytosolic phospholipase A2 after UVB injury. Biochim Biophys Acta. 1299:1996;23-33.
4. Isoherranen K., Punnonen K., Jansen C., et al. Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes. Br J Dermatol. 140:1999;1017-1022.
5. Wong E., Bayly C., Waterman H.L., et al. Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 → Arg and Ile523 → val mutation. J Biol Chem. 272:1997;9280-9286.
6. McGahon A.J., Martin S.J., Bissonnette R.P., et al. The end of the (cell) line Methods for the study of apoptosis in vitro . Methods Cell Biol. 46:1995;153-185.
7. Kulmacz R.J., Wang L.H. Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2. J Biol Chem. 270:1995;24019-24023.
8. Jones M.K., Wang H., Peskar B.M., et al. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs Insight into mechanisms and implications for cancer growth and ulcer healing . Nat Med. 5:1999;1418-1423.
9. Kishi K., Petersen S., Petersen C., et al. Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor. Cancer Res. 60:2000;1326-1331.
10. Ryu H.S., Chang K.H., Yang H.W., et al. High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion. Gynecol Oncol. 76:2000;320-325.
11. Milas L., Hanson W.R. Eicosanoids and radiation. Eur J Cancer. 31A:1995;1580-1585.
12. Milas L., Furuta Y., Hunter N., et al. Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence. Cancer Res. 50:1990;4473-4477.
13. Milas L., Kishi K., Hunter N., et al. Enhancement of tumor response to gamma-radiation by an inhibitor of cyclooxygenase-2 enzyme. J Natl Cancer Inst. 91:1999;1501-1504.
14. Ben-Av P., Crofford L.J., Wilder R.L., et al. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1 A potential mechanism for inflammatory angiogenesis . FEBS Lett. 372:1995;83-87.
15. Gorski D.H., Beckett M.A., Jaskowiak N.T., et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 59:1999;3374-3378.
16. Chaudry A.A., Wahle K.W., McClinton S., et al. Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro Effects of fatty acids and cyclooxygenase inhibitors . Int J Cancer. 57:1994;176-180.
17. Gupta S., Srivastava M., Ahmad N., et al. Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. Prostate. 42:2000;73-78.
18. Tjandrawinata R.R., Dahiya R., Hughes-Fulford M. Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. Br J Cancer. 75:1997;1111-1118.